Inhibition of genotoxicity by saffron (Crocus sativus L.) in mice.

abstract：:Pefloxacin is a second-generation fluoroquinolone antibiotic. Besides its advantageous characteristics, side effects including the hypofunction of salivary glands, decreased saliva production, and peripheral neuropathy were observed during the administration of pefloxacin. The aim of this study was to investigate the ...

journal_title：Drug and chemical toxicology

authors： Skopkó BE,Deák Á,Matesz C,Kelentey B,Bácskai T

更新日期：2020-09-01 00:00:00

abstract：:Nephrotoxicity is a major limitation of adriamycin (ADR) chemotherapy. We hypothesized that administration of standardized aqueous bark extract of Gmelina arborea Roxb. (GA) (Family; Verbenaceae), a traditional therapeutic agent, may reduce the nephrotoxicity caused by ADR in Wistar rats. The dose-dependent nephroprot...

journal_title：Drug and chemical toxicology

authors： Amarasiri SS,Attanayake AP,Arawwawala LDAM,Jayatilaka KAPW,Mudduwa LKB

更新日期：2020-08-30 00:00:00

abstract：:The intoxication of insecticides such as bifenthrin and diazinon has been reported to generate free radicals, and thereby alter the antioxidant defense system in erythrocytes. The present study is aimed to investigate the protective effects of acetone (DA) and methanolic (DM) extracts of lichen Dirinaria consimilis ag...

journal_title：Drug and chemical toxicology

authors： Tatipamula VB,Kukavica B

更新日期：2020-05-12 00:00:00

abstract：:The cross-reaction patterns of selected acrylate and methacrylate esters were investigated using the guinea pig maximization test. Methacrylates were less potent sensitizers than acrylates. Cross-sensitization was found between (meth)acrylates with closely related core structures, most extensively between hydroxyethyl...

journal_title：Drug and chemical toxicology

authors： Clemmensen S

更新日期：1984-01-01 00:00:00

abstract：:In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were administered to the rats for 1 week. Serum biochemical cardiotoxicity parameters and tissue malond...

journal_title：Drug and chemical toxicology

authors： Saraçoğlu A,Temel HE,Ergun B,Colak O

更新日期：2009-01-01 00:00:00

abstract：:Genotoxicity of nimesulide (NM) was evaluated by employing bone marrow (BM) chromosomal aberration (CA) and micronucleus assays in Swiss albino mice. For BM CA assay, mice of either sex were treated orally with 1.5, 2.5 and 5 mg body weight solution of NM in 0.2 mL of 0.05% CMC (carboxy methyl cellulose) daily for 4, ...

journal_title：Drug and chemical toxicology

authors： Tripathi R,Tripathi P,Pancholi SS,Patel CN

更新日期：2014-07-01 00:00:00

abstract：:This study was designed to test the pulmonary tumor response to intratracheally instilled silica in Strain A mice. Urethane was used as a positive control. Silica treatment was utilized to evaluate the effect of a potent fibrinogen on pulmonary adenoma formation in this unique animal model. Urethane produced an increa...

journal_title：Drug and chemical toxicology

authors： McNeill DA,Chrisp CE,Fisher GL

更新日期：1990-01-01 00:00:00

abstract：:In this study, we investigated the effect of vernolide-A on the induction of apoptosis as well as its regulatory effect on the activation of transcription factors in B16F-10 melanoma cells. Treatment of B16F-10 cells with nontoxic concentrations of vernolide-A showed the presence of apoptotic bodies and induced DNA fr...

journal_title：Drug and chemical toxicology

authors： Pratheeshkumar P,Kuttan G

更新日期：2011-07-01 00:00:00

abstract：:Endophytic fungi are promising sources of bioactive substances; however, their secondary metabolites are toxic to plants, animals, and humans. This study aimed toevaluate the toxic, cytotoxic, mutagenic and oxidant/antioxidant activities of acetonitrile extract (AEPc), citrinin (CIT) and dicitrinin-A (DIC-A) of Penici...

journal_title：Drug and chemical toxicology

authors： de Oliveira Filho JWG,Andrade TJADS,de Lima RMT,Silva DHS,Dos Reis AC,Santos JVO,de Meneses APM,de Carvalho RM,da Mata AMO,de Alencar MVOB,Dias ACS,da Silva FCC,Islam MT,Clark CCT,Sousa JMCE,Melo-Cavalcante AAC

更新日期：2020-05-25 00:00:00

abstract：:While it is well recognized that the combination of amoxicillin and clavulanic acid has been associated with hepatic adverse events, there are only a few reports about amoxicillin alone causing hepatic toxicity. We describe a 34-year-old woman who developed severe cholestatic hepatitis following amoxicillin treatment....

journal_title：Drug and chemical toxicology

authors： Chaabane NB,Safer L,Njim L,Zakhama A,Saffar H

更新日期：2011-10-01 00:00:00

abstract：:Cardiotoxicity is commonly associated with cocaine abuse. Previous studies have indicated that cocaine alters myocardial mitochondrial function. This study was undertaken to investigate the effect of cocaine on activity of the mitochondrial electron transport chain in cultures of neonatal rat cardiomyocytes and in iso...

journal_title：Drug and chemical toxicology

authors： Yuan C,Acosta D Jr

更新日期：2000-05-01 00:00:00

abstract：:Various antioxidants play an important role in reducing the reactive oxygen species (ROS) by scavenging them directly or indirectly. Mercury (Hg) is one of the known hazardous genotoxicant, induces the genotoxicity by enhancing the ROS. In the present study, three structurally different bioactive compounds such as mel...

journal_title：Drug and chemical toxicology

authors： Patel TA,Rao MV

更新日期：2015-10-01 00:00:00

abstract：:Cisplatin (CP) is a widely used cytotoxic agent against cancer, and high doses of CP have been known to cause nephrotoxicity and hepatotoxicity. Some reports claim that antioxidants can reduce CP-induced toxicity. This study investigated the hepatoprotective, nephroprotective, and antioxidant activity of Urtica dioica...

journal_title：Drug and chemical toxicology

authors： Özkol H,Musa D,Tuluce Y,Koyuncu I

更新日期：2012-07-01 00:00:00

abstract：:Adriamycin (ADR) causes morphological and functional alterations in mitochondrial structure in the heart. The study's aim was to determine whether there is a protective effect of selenium (Se) on ADR-induced cardiac damage. Rats were divided into four groups: The first group was injected saline intraperitoneally (i.p....

journal_title：Drug and chemical toxicology

authors： Dursun N,Taşkın E,Yerer Aycan MB,Sahin L

更新日期：2011-04-01 00:00:00

abstract：:Cyclododecatriene (CDDT, CAS No. 4904-61-4) was administered daily by oral gavage to groups of Crl:CD (SD)IGS BR rats at dose levels of 0 (control), 30, 100, or 300 mg/kg/day. Female rats were dosed for four weeks premating, through mating, gestation, and lactation (a total of 55 to 63 days of treatment). Male rats we...

journal_title：Drug and chemical toxicology

authors： Malley LA,Everds NE,Makovec GT,Kennedy GL Jr

更新日期：2002-05-01 00:00:00

abstract：:The median lethal dose (LD50) of chymopapain B in mice was 82 mg/kg (22,000 units/kg) with 95% confidence limits of 75-90 mg/kg (20, 122-24, 146 units/kg) and in rats 92 (24,683 units/kg) with 95% confidence limits of 83-102 mg/kg (22,268-27, 366 units/kg). The mechanism of toxicity was hemorrhage due to destruction o...

journal_title：Drug and chemical toxicology

authors： Simmons JW,Upman PJ,Stavinoha WB

更新日期：1984-01-01 00:00:00

abstract：:Transient global ischemia continues to be an important clinical problem with limited treatment options. The present study aimed to investigate the possible protective effects of celecoxib [a selective cyclooxygenase (COX-2) inhibitor] and N-omega-nitro-L-arginine methyl ester (L-NAME) [a nonselective nitric oxide synt...

journal_title：Drug and chemical toxicology

authors： Abd El-Aal SA,El-Sawalhi MM,Seif-El-Nasr M,Kenawy SA

更新日期：2013-10-01 00:00:00

abstract：:The responses of atria isolated from four groups of rats: (a) control (air/H2O) and test animals treated with (b) 5 PPM nitrogen dioxide NO2 for 72 hours, (NO2/H2O), (c) 10% ethanol (ET) in water for 13 days, (air/ET), or (d) combination of NO2 and ET (NO2/ET). Isolated atria were tested with norepinephrine and dose r...

journal_title：Drug and chemical toxicology

authors： Early J,McGrath J,Messiha FS,Hughes MJ

更新日期：1983-01-01 00:00:00

abstract：:Orlistat is an FDA-approved over-the-counter drug to treat obesity through the inhibition of lipase activity. Macrophages, which express high levels of lipoprotein lipase (LPL), are important phagocytes in the innate immune system. Our previous studies indicated that environmentally relevant concentrations of arsenite...

journal_title：Drug and chemical toxicology

authors： Lou K,Huang P,Ma H,Wang X,Xu H,Wang W

更新日期：2019-10-31 00:00:00

abstract：:Butea monosperma (Lam.) Taub. is an ethnomedicinal tree of remedial value in the treatment of diabetes, bone fractures, and liver and neurological disorders. However, the information available on DNA-protective and anti-proliferative potential of bark of this tree is scarce. In the present study, the extract/fractions...

journal_title：Drug and chemical toxicology

authors： Kaur V,Kumar M,Kumar A,Kaur S

更新日期：2020-07-01 00:00:00

abstract：:The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and the National Oil and Hazardous Substances Pollution Contingency Plan (NCP) mandate protection of public health, welfare, and the environment at Superfund hazardous waste sites. The NCP requires lead response agenciesto integrate bas...

journal_title：Drug and chemical toxicology

authors： Fritz AT,Buchman MF

更新日期：1997-11-01 00:00:00

abstract：:Aluminum (Al)-induced toxicity in fruit fly (Drosophila melanogaster) is one of the established models for studying neurotoxicity and neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, the aim of this study is to determine the effect of alkaloid extrac...

journal_title：Drug and chemical toxicology

authors： Adedayo BC,Ogunsuyi OB,Akinniyi ST,Oboh G

更新日期：2020-01-03 00:00:00

abstract：:The potential maternal and developmental toxicity of cyclododecatriene (CDDT) was assessed in rats. Groups of 22 time-mated female Crl:CD (SD) BR rats were exposed by inhalation (whole-body, 6 h/day) to either 0 (control), 10, 25, or 67 ppm CDDT over days 6-20 of gestation (days 6-20 G); the day of copulation plug det...

journal_title：Drug and chemical toxicology

authors： Munley SM,Kelly DP,Kennedy GL Jr

更新日期：2003-08-01 00:00:00

abstract：:Given the increasing prevalence of occupational sensitization to acrylate compounds, n-butyl acrylate (BAC), ethyl acrylate (EAC), and trimethylol propane triacrylate (TMT) were recommended by the National Toxicology Program for hypersensitivity testing in female B6C3F1 mice. The objectives of these studies were to de...

journal_title：Drug and chemical toxicology

authors： Hayes BB,Meade BJ

更新日期：1999-08-01 00:00:00

abstract：:Currently, no standardized and well-validated alternative models exist for screening for progesterone-responsive endocrine disrupting chemicals (EDCs). Because of this, a rapid assay for evaluating progestin/antiprogestin activity using Xenopus oocyte germinal vesicle breakdown (GVBD) as a model was evaluated. Five co...

journal_title：Drug and chemical toxicology

authors： Fort DJ,McLaughlin DW,Rogers RL,Buzzard BO

更新日期：2002-08-01 00:00:00

abstract：:The nicotine metabolism of CYP2A6 (CYP2A6*1A,*1B, and *1C), and the cholecystokinin (CCK; which modulates the release of dopamine) and CCK-A receptor gene and personality traits for NEO-FFI, was investigated for the mechanism for elucidation of the smoking behavior in Japanese populations. The frequency of the CYP2A6*...

journal_title：Drug and chemical toxicology

authors： Iwahashi K,Aoki J

更新日期：2009-01-01 00:00:00

abstract：:Pachira aquatica is a species used for medicinal and food purposes and has numerous phytochemicals that may have systemic toxic effects and damage to genetic material. This study aimed to evaluate acute and short-term oral toxicity, as well as genotoxic and clastogenic effects of oil extracted from P. aquatica (PASO) ...

journal_title：Drug and chemical toxicology

authors： Marcelino JM,Villas Boas GR,Cunha M,Deus Júnior R,Castro LH,Araújo FH,Traesel GK,Dos Santos AC,Souza RI,Paes M,Gubert P,Guterres ZDR,de Lima FF,Silva T,Silva RC,Cardoso CAL,Argandoña EJ,Macorini LF,Oesterreich SA

更新日期：2020-11-30 00:00:00

abstract：:For centuries, Turkey has been a significant location here around 80 species of Hypericum with differing names widely occur, which is also known as Turkish folk medicine in treating some bacterial diseases as well as stomach and intestine inflammation. Recent studies have reported this herb family to contain numbers o...

journal_title：Drug and chemical toxicology

authors： Can S,Çetik Yıldız S,Keskin C,Şahintürk V,Cengiz M,Appak Başköy S,Ayhanci A,Akıncı G

更新日期：2020-12-06 00:00:00

abstract：:This Visual Basic computer program has been developed for drug dosage conversions using metabolically active mass (MAM) of the animals. The two body weights (one with known dosage and the other, for which the dosage has to be calculated) and the known dosage are entered in the respective input boxes and the appropriat...

journal_title：Drug and chemical toxicology

authors： Khan HA

更新日期：2003-02-01 00:00:00

abstract：CONTEXT:Crack cocaine is an illicit drug derived from cocaine, in which use and abuse have increased around the world, especially in developing countries. OBJECTIVES:The aim of this study was to evaluate genomic damage in multiple organs of mice following acute exposure to crack cocaine. For this purpose, single cell ...

journal_title：Drug and chemical toxicology

authors： Yujra VQ,Moretti EG,Claudio SR,Silva MJ,Oliveira Fd,Oshima CT,Ribeiro DA

更新日期：2016-10-01 00:00:00