Abstract:
:For centuries, Turkey has been a significant location here around 80 species of Hypericum with differing names widely occur, which is also known as Turkish folk medicine in treating some bacterial diseases as well as stomach and intestine inflammation. Recent studies have reported this herb family to contain numbers of bioactive compound contents. The study aims to investigate the protective effects of Hypericum triquetrifolium Turra (HT) upon oxidative stress and apoptosis in a rat model in which testes injury was induced by CP. The testicular injury was caused using CP (150 mg/kg). The rats were treated with a single dose (100 mg/kg) of methanol extract of HT to investigate various biochemical markers in the serum and plasma of blood samples apart from assessing the prognosis of CP-induced testicular damage. Added to that, histological analyses were performed to identify possible structural changes and apoptotic indicators, like Bax, Caspase-3, and Bcl-2. In CP Group, there was a rise in the levels of total oxidant status (TOS), malondialdehyde (MDA), oxidative stress index (OSI), Caspase-3, and Bax while superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), Bcl-2, and total antioxidant capacity (TAC) all decreased. Also, our histological analysis showed damaged testes. On the other hand, neither biochemical nor histological analysis showed testicular damage in HT Alone Group. In CP + HT Group, a significant number of the negatives changes due to CP were observed to have improved remarkably following an HT treatment. This study results suggest that HT could help improve CP-induced testicular injury thanks to its anti-oxidative and anti-apoptotic properties.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Can S,Çetik Yıldız S,Keskin C,Şahintürk V,Cengiz M,Appak Başköy S,Ayhanci A,Akıncı Gdoi
10.1080/01480545.2020.1856130subject
Has Abstractpub_date
2020-12-06 00:00:00pages
1-8eissn
0148-0545issn
1525-6014pub_type
杂志文章abstract::During a preclinical safety evaluation study, an indication of ocular toxicity was noted in beagle dogs receiving orally (gelatin capsules) once a day, 7 days a week for, respectively, 7 and 91 days, 10 mg/kg/day of Lortalamine, a new non-tricyclic anti-depressant compound. Lortalamine treated dogs showed, progressive...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549009032289
更新日期:1990-01-01 00:00:00
abstract::A toxicity Evaluation of DDT and dieldrin was conducted using Japanese Quail. The effects of feeding DDT (5 and 50 ppm of diet) and dieldrin (0.1 and 1.0 ppm of diet) in this four generation study (parental, F1, F2 and F3) were examined in terms of growth, viability, and/or reproduction of offspring. Ten groups (inclu...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480547809034431
更新日期:1978-01-01 00:00:00
abstract::In May 1993, Administrative Browner of the U.S. Environmental Protection Agency (USEPA) announced that an indirect exposure health risk assessment was required for all hazardous waste combustion facilities seeking a Resource Conservation and Recovery Act permit. These types of risk assessments evaluate the health and ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-100100103
更新日期:2000-02-01 00:00:00
abstract::Albino mice (8-10 wks) weighing between 14 and 25 g were divided into 2 groups and dosed orally once per week with 2 doses (7 mg/kg and 21 mg/kg) of the gut-stimulating principle in Croton penduliflorus seeds (CP crystals) for 12 weeks. Some mice (3-4) from each group were killed at 10 days intervals for the first 6 w...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548908999146
更新日期:1989-03-01 00:00:00
abstract:CONTEXT:Celtis glabrata is used in Turkey for the treatment of various health disorders. OBJECTIVE:The acetone, chloroform, ethanol, and methanol extracts of C. glabrata leaf, fruit, and seed were investigated to evaluate their antimutagenic activities. MATERIAL AND METHODS:The antimutagenicity of these extracts was ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2015.1121273
更新日期:2016-01-01 00:00:00
abstract::In view of the ability of several phosphoesterases to hydrolyze organophosphates to toxic phenols, the bioactivation of bis[p-nitrophenyl]phosphate (BNPP) by the earthworm Lumbricus terrestris was investigated. In a contact toxicity test, BNPP was was less toxic than the metabolite p-nitrophenol (PNP), but more toxic ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549309038664
更新日期:1993-01-01 00:00:00
abstract::This review summarizes the effects of more than 20 metals that, research has indicated, may influence male reproductive health. Though males lack an apparent, easily measurable reproductive cycle, progress has been made in evaluating tests to identify chemical hazards and estimate reproductive health risks. Some agent...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章,评审
doi:10.3109/01480545.2012.710631
更新日期:2013-07-01 00:00:00
abstract::Methyl 2,2-difluoromalonyl fluoride (MMF) is highly toxic by inhalation producing mortality in rats exposed for 4 hours to 0.55 mg/L. Repeated inhalation exposures of rats to 0.009 mg/L produced irritation but no other signs of a toxic response. Mortality was encountered following repeated exposures to 0.066 mg/L. ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548808998223
更新日期:1988-06-01 00:00:00
abstract::Cardiotoxicity is commonly associated with cocaine abuse. Previous studies have indicated that cocaine alters myocardial mitochondrial function. This study was undertaken to investigate the effect of cocaine on activity of the mitochondrial electron transport chain in cultures of neonatal rat cardiomyocytes and in iso...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-100100119
更新日期:2000-05-01 00:00:00
abstract::1-((2-methyl-4-[(2-methyl phenyl)azo] phenyl)azo)-2-naphthalenol (C.I. Solvent Red 24) was prepared having a 14C label on the methyl group of the central ring and was administered in suspension intra-tracheally to a male and a female rat. After 96 hours in metabolism cages, the animals were sacrificed and 14C counted ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480547909016034
更新日期:1979-01-01 00:00:00
abstract::Eight antineoplastic drugs were evaluated for their ability to induce mutation in the Ames Salmonella/microsome and the TK+/- mouse lymphoma assay. Dose response data were utilized to determine the relative potency of each of these drugs. They were then ranked based on this information. Vincristine, the most potent co...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480547809105021
更新日期:1978-01-01 00:00:00
abstract::It is generally thought that residual unpolymerized (meth)acrylic monomers commonly found in pressure sensitive adhesive tapes for medical use may cause dermal irritation, but a systematic study has never been carried out. Therefore, we assessed the potential dermal irritating effect of residual (meth)acrylic monomers...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480540903311043
更新日期:2010-01-01 00:00:00
abstract::The status of brain antioxidant enzymes and glutathione in methacrylonitrile (MeAN)-intoxicated Wistar rats was correlated with the levels of lipid peroxidation products. Optimum changes were observed 30 min and 60 min after oral administration of MeAN at dosages of 50 mg/kg body weight per day (0.25 LD50) and 100 mg/...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-52536
更新日期:2005-01-01 00:00:00
abstract::Celecoxib has been shown to have an antitumor effect in previous studies, but the mechanisms are unclear. Ca(2+) is a key second messenger in most cells. The effect of celecoxib on cytosolic free Ca(2+) concentrations ([Ca(2+)](i)) in human suspended PC3 prostate cancer cells was explored by using fura-2 as a fluoresc...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2011.638927
更新日期:2012-10-01 00:00:00
abstract::In this study, the hepatoprotective activity of methanol bark extract of Alangium salviifolium (BEA) was evaluated for biochemical and histological parameters in swiss albino mice with CCl4-induced hepatotoxicity. The hepatomodulatory effect of two doses of BEA (20 and 50 mg/kg bw for 15 days by oral gavage) was asses...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1733593
更新日期:2020-03-06 00:00:00
abstract::The present study was aimed at exploring the effect of monensin, an antibiotic carboxylic polyether ionophore specific for Na(+), on the structural, chemical, and physiological changes of the epididymal sperm of Wistar rats. Animals received monensin at the dose of 3.5 mg/kg body weight daily orally for 70 days, a tre...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2011.650174
更新日期:2013-01-01 00:00:00
abstract::A comparison of the fertility and cytogenetic analyses and the combination of both techniques as generally used in the heritable translocation assay was conducted with triethylenemelamine (TEM). CD-1 mice were used as the F0 generation and were divided into two groups that received i.p. either distilled water (control...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548309017808
更新日期:1983-01-01 00:00:00
abstract::In adult female Wistar rats, pretreated by gavage with two doses - 16 or 256 mumol/kg - of cyanamide, TMTD (tetramethylthiuram disulfide), TMTM (tetramethylthiuram monosulfide), Ziram or Zineb at 90 min or 18 h before administration of 2 g of ethanol/kg i.p., the blood acetaldehyde levels were significantly increased ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548309082713
更新日期:1983-01-01 00:00:00
abstract::This study was conducted to evaluate the potential reproductive toxicity of epichlorohydrin in a one-generation reproduction toxicity study in compliance with OECD Test Guideline 415. Twenty-four male and female rats per group were given epichlorohydrin by gavage at 0, 3.3, 10, and 30 mg/kg/day. Males were dosed for 1...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480541003734030
更新日期:2010-07-01 00:00:00
abstract::The effects of feeding two compounds, dehydroepiandrosterone (DHEA), an adrenal steroid, and clofibrate (CLOF) to rats (which are both hypolipidemic, hepatomegaly inducing and hepatic peroxisome proliferating agents) on the binding of 7,12-dimethylbenz(a)anthracene (DMBA) to hepatic DNA in vivo is compared. Male Sprag...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548908999162
更新日期:1989-09-01 00:00:00
abstract::Modafinil is used for the treatment of various sleep disorders; however, its usage among healthy individuals is also increasing. There are a limited number of cardiovascular side effects, including ischemic T-wave changes, dyspnea, hypertension, and tachycardia in the literature. Our research aimed to investigate the ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1803906
更新日期:2020-08-11 00:00:00
abstract::Cisplatin (CP) is a widely used cytotoxic agent against cancer, and high doses of CP have been known to cause nephrotoxicity and hepatotoxicity. Some reports claim that antioxidants can reduce CP-induced toxicity. This study investigated the hepatoprotective, nephroprotective, and antioxidant activity of Urtica dioica...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2011.598531
更新日期:2012-07-01 00:00:00
abstract::Cis-1,2-dichloroethylene was administered daily by corn oil gavage to male and female Sprague-Dawley rats at the following dose levels: 1.0, 3.0, 10.0 and 22.0 mmol/kg/day for 14 days. Doses gavaged during the 90-day subchronic study were 0.33, 1.00, 3.00 and 9.00 mmol/kg/day. There were no compound-related deaths or ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549509014319
更新日期:1995-05-01 00:00:00
abstract::Copper (Cu) is a heavy metal with the ability to induce, at high levels, neurobehavioral alterations, and oxidative stress (OS). On the other hand, melatonin (Mel) is a neurohormone that protects neurons from OS and has a modulatory effect on several behavioral processes. The present experiment was aimed to examine th...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1858853
更新日期:2021-01-07 00:00:00
abstract::Increasing numbers of older adults use cannabis and cannabis-derived products that can have adverse effects. This study examined management site and level of healthcare services for older adult poison control center cases involving cannabis products. Using the American Association of Poison Control Centers' (PCC) Nati...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1868494
更新日期:2021-01-07 00:00:00
abstract::Many steps are required to convert a normal cell into a cancerous one. The cancer cell must be able to multiply under conditions that a normal cell would not and to invade surrounding tissue and spread throughout the body. Both genetic changes, such as activation of oncogenes or inactivation of tumor suppressor genes,...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章,评审
doi:10.3109/01480549608998231
更新日期:1996-08-01 00:00:00
abstract::Butea monosperma (Lam.) Taub. is an ethnomedicinal tree of remedial value in the treatment of diabetes, bone fractures, and liver and neurological disorders. However, the information available on DNA-protective and anti-proliferative potential of bark of this tree is scarce. In the present study, the extract/fractions...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1497051
更新日期:2020-07-01 00:00:00
abstract::The present study enumerates the attenuating effects of curcumin and α-tocopherol against propoxur induced oxidative DNA damage in human peripheral blood mononuclear cells (PBMC). Cultured cells were isolated from peripheral blood of healthy volunteers, and were exposed to varying concentrations of propoxur (0-21 μg/m...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2017.1321010
更新日期:2018-04-01 00:00:00
abstract::Pefloxacin is a second-generation fluoroquinolone antibiotic. Besides its advantageous characteristics, side effects including the hypofunction of salivary glands, decreased saliva production, and peripheral neuropathy were observed during the administration of pefloxacin. The aim of this study was to investigate the ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1508217
更新日期:2020-09-01 00:00:00
abstract::The purpose of this study was to assess the compatibility, in terms of red blood cell acetylcholinesterase (AChE) inhibition, of ondansetron (OND; a 5-hydroxytryptamine subtype-3 receptor antagonist) with the organophosphorus pretreatment compound pyridostigmine (PYR) after simultaneous oral (p.o.) administration to g...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549609002193
更新日期:1996-01-01 00:00:00