Assessment of antimutagenic action of Celtis glabrata Steven ex Planch. (Cannabaceae) extracts against base pair exchange and frame shift mutations on Salmonella typhimurium TA98 and TA100 strains by Ames test.

abstract：:Peroxysomicine A1, a novel potential anticancer compound induced cell death in established cell lines and in a primary culture of rat neonatal cardiomyocytes. Non-transformed cells are less sensitive to the compound than transformed cell lines. Fluorescent microscopy of dying cells stained with DNA-specific dyes revea...

journal_title：Drug and chemical toxicology

authors： Martinez FJ,Zeng GQ,Piñeyro A,Garza-Ocañas L,Tomei LD,Umansky SR

更新日期：2001-08-01 00:00:00

abstract：:The objective of this study was to evaluate the residues of 42 pesticides subject to public concern in Tieguanyin tea produced in Fujian, China. The presence of 42 pesticide residues in 90 Tieguanyin tea samples were determined. A total of 17 pesticides were detected. At least one pesticide residue was detected in 65 ...

journal_title：Drug and chemical toxicology

authors： Yao Q,Yan SA,Li J,Huang M,Lin Q

更新日期：2020-08-04 00:00:00

abstract：:Fertilized hen eggs were topically applied with 2,4-Dichlorophenoxyacetic acid butyl ester (3.1 mg/egg) before starting incubation. During the incubation time 20% of the compound applied on eggs was lost by volatilization. At different incubation times (0, 1, 5, 10 and 15 days) the wash-off technique was applied to fe...

journal_title：Drug and chemical toxicology

authors： Castro de Cantarini SM,Evangelista de Duffard AM,Duffard RO

更新日期：1989-06-01 00:00:00

abstract：:An automatic system was developed to monitor continuously the colonic temperature of laboratory animals during inhalation exposure to toxic chemicals. It includes: an automatic switchbox, a control circuit, a recorder and a digital voltmeter. The system was calibrated for different temperature ranges and used for a ye...

journal_title：Drug and chemical toxicology

authors： Laham S,Schrader K,Symonds G,Curtin W

更新日期：1978-01-01 00:00:00

abstract：:Organoselenium compounds can cause anemia in mice, possibly as a consequence of impairment of the heme biosynthesis pathway. Such compounds can inhibit the sulfhydryl-containing enzyme delta-aminolevulinate dehydratase (delta-ALA-D), which is involved in the heme biosynthetic pathway, leading to a decrease in the synt...

journal_title：Drug and chemical toxicology

authors： Folmer V,Farina M,Maciel EN,Nogueira CW,Zeni G,Emanuelli T,Rocha JB

更新日期：2004-11-01 00:00:00

abstract：:The nicotine metabolism of CYP2A6 (CYP2A6*1A,*1B, and *1C), and the cholecystokinin (CCK; which modulates the release of dopamine) and CCK-A receptor gene and personality traits for NEO-FFI, was investigated for the mechanism for elucidation of the smoking behavior in Japanese populations. The frequency of the CYP2A6*...

journal_title：Drug and chemical toxicology

authors： Iwahashi K,Aoki J

更新日期：2009-01-01 00:00:00

abstract：:Prolonged exposure to aluminum through occupational hazards or food/water intake has been linked to the occurrence of Alzheimer's disease (AD). This study aimed at investigating the neuroprotective effects of Gallic Acid (GA) against aluminum-chloride induced AD in adult Wistar rats. Twenty eight (28) adult Wistar rat...

journal_title：Drug and chemical toxicology

authors： Ogunlade B,Adelakun SA,Agie JA

更新日期：2020-04-24 00:00:00

abstract：:p-Octopamine occurs naturally in plants, invertebrates and animals with diverse functions and effects. This review summarizes the chemistry, metabolism, receptor binding characteristics, known physiological functions, and pharmacological and toxicological effects of p-octopamine. Databases used included PubMed and Goo...

journal_title：Drug and chemical toxicology

authors： Stohs SJ

更新日期：2015-01-01 00:00:00

abstract：:Gold nanorods (GNRs) are used for their wide variety of applications in various industries. There is a little availability of data related to toxicity and ecological implications of these GNRs. The study evaluated the oxidative stress induction following intra-tracheal instillation of 1 and 5 mg/kg b.w. doses of 10 an...

journal_title：Drug and chemical toxicology

authors： Lingabathula H,Yellu N

更新日期：2018-04-01 00:00:00

abstract：:Chemical pretreatment is effective against a 2 LD50 challenge of soman, sarin or VX or a 5 LD50 challenge of tabun. Chemical pretreatment followed by post challenge therapy should be effective against greater levels of agent. Such tests in guinea pigs are reported here; pretreatment regimens (PRGs) consisted of physos...

journal_title：Drug and chemical toxicology

authors： Lennox WJ,Harris LW,Anderson DR,Solana RP,Murrow ML,Wade JV

更新日期：1992-01-01 00:00:00

abstract：:The antigenotoxic activity of glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) in human peripheral lymphocytes exposed to oxidative stress was investigated. Human lymphocytes were treated with different concentrations of these aminosugars (0, 2.5, 5, 10, 20 and 40 mM) and 25 µM H2O2 simultaneously and evaluated by ...

journal_title：Drug and chemical toxicology

authors： Jamialahmadi K,Soltani F,Nabavi Fard M,Behravan J,Mosaffa F

更新日期：2014-10-01 00:00:00

abstract：:As a measure of glutathione (GSH) conjugation, urinary, fecal and biliary excretion of thioethers and hepatic GSH content were measured in rhesus monkeys following administration of single doses of naphthalene and diethylmaleate (DEM). Naphthalene had little or no effect on hepatic GSH content and the excretion of thi...

journal_title：Drug and chemical toxicology

authors： Rozman K,Summer KH,Rozman T,Greim H

更新日期：1982-01-01 00:00:00

abstract：:In this study, the hepatoprotective activity of methanol bark extract of Alangium salviifolium (BEA) was evaluated for biochemical and histological parameters in swiss albino mice with CCl4-induced hepatotoxicity. The hepatomodulatory effect of two doses of BEA (20 and 50 mg/kg bw for 15 days by oral gavage) was asses...

journal_title：Drug and chemical toxicology

authors： Dhruve P,Nauman M,Kale RK,Singh RP

更新日期：2020-03-06 00:00:00

abstract：:Hexachloroethane (HCE) was fed to Fischer 344 rats at approximate doses of 0, 1, 15 or 62 mg/kg/day for 16 weeks. Selected tissues were assayed at termination for HCE content. Histopathological examination identified the kidney as the primary target organ with male rats more sensitive than female rats. The kidney conc...

journal_title：Drug and chemical toxicology

authors： Gorzinski SJ,Nolan RJ,McCollister SB,Kociba RJ,Mattsson JL

更新日期：1985-01-01 00:00:00

abstract：:The antioxidant and drug metabolizing potentials of Hibiscus anthocyanin extract in CCl(4)- induced oxidative damage of rat liver was investigated. Hibiscus anthocyanin extract effectively scavenge α-diphenyl-β-picrylhydrazyl (DPPH) radical, superoxide ion, and hydrogen peroxide. It produced a 92% scavenging effect of...

journal_title：Drug and chemical toxicology

authors： Ajiboye TO,Salawu NA,Yakubu MT,Oladiji AT,Akanji MA,Okogun JI

更新日期：2011-04-01 00:00:00

abstract：:This review summarizes the effects of more than 20 metals that, research has indicated, may influence male reproductive health. Though males lack an apparent, easily measurable reproductive cycle, progress has been made in evaluating tests to identify chemical hazards and estimate reproductive health risks. Some agent...

journal_title：Drug and chemical toxicology

authors： Sengupta P

更新日期：2013-07-01 00:00:00

abstract：:Chronic exposure to solar ultraviolet (UV) light induces photoaging in human skin. Our previous results have shown that areca nut procyanidins (ANPs) have antioxidant capacity and possess potential anti-inflammatory effects. Here, we aimed to investigate the effect of ANPs on UVB-induced photoaging. In the present stu...

journal_title：Drug and chemical toxicology

authors： Weng CL,Chen CC,Tsou HH,Liu TY,Wang HT

更新日期：2019-12-02 00:00:00

abstract：:The potential maternal and developmental toxicity of cyclododecatriene (CDDT) was assessed in rats. Groups of 22 time-mated female Crl:CD (SD) BR rats were exposed by inhalation (whole-body, 6 h/day) to either 0 (control), 10, 25, or 67 ppm CDDT over days 6-20 of gestation (days 6-20 G); the day of copulation plug det...

journal_title：Drug and chemical toxicology

authors： Munley SM,Kelly DP,Kennedy GL Jr

更新日期：2003-08-01 00:00:00

abstract：:Exposure to crude acetylene can occur in occupational settings. This study assessed the modulatory activities of selected polyphenols on the hematotoxic, cardiotoxic, and hepatotoxic effects of crude acetylene. Wistar rats were exposed to 58 000 ppm crude acetylene for 10 min at 12 h intervals for 30 days. Some expose...

journal_title：Drug and chemical toxicology

authors： Aladesanmi OO,Akinmoladun AC,Josiah SS,Olaleye MT,Akindahunsi AA

更新日期：2020-12-08 00:00:00

abstract：:Aluminum (Al)-induced toxicity in fruit fly (Drosophila melanogaster) is one of the established models for studying neurotoxicity and neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, the aim of this study is to determine the effect of alkaloid extrac...

journal_title：Drug and chemical toxicology

authors： Adedayo BC,Ogunsuyi OB,Akinniyi ST,Oboh G

更新日期：2020-01-03 00:00:00

abstract：:Various chemical groups were evaluated for their skin sensitization potential in the guinea pig. In general, amines, acetanilides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further structural-related correlations or predictions sh...

journal_title：Drug and chemical toxicology

authors： Rao KS,Betso JE,Olson KJ

更新日期：1981-01-01 00:00:00

abstract：:Concerns that chemical warfare (CW) agents themselves or in combination with other chemicals may cause long-term damage to nerve and muscle are reviewed and discussed. Experiments on mice and hens underway with agent GA and pyridostigmine bromide (PB) and their effects (either separately or together) are presented. ...

journal_title：Drug and chemical toxicology

authors： Wilson BW,Henderson JD,Spencer PS

更新日期：1998-01-01 00:00:00

abstract：:Medications show their biological effects by interaction with enzymes, which have been known to play an essential role in the pathogenesis of many diseases. Inhibition or induction of drug metabolizing enzymes has an essential place in the drug design for many kinds of diseases including cardiovascular, neurological, ...

journal_title：Drug and chemical toxicology

authors： Beydemir Ş,Türkeş C,Yalçın A

更新日期：2019-06-09 00:00:00

abstract：:This paper discusses the merits and disadvantages of a specific proposal for a numerical calculation of the reference dose (RfD) with explicit recognition of both uncertainty and variability. It is suggested that the RfD be the lower (more restrictive) value of: The daily dose rate that is expected (with 95% confidenc...

journal_title：Drug and chemical toxicology

authors： Hattis D,Baird S,Goble R

更新日期：2002-11-01 00:00:00

abstract：:We designed this study to identify the factors associated with time to successful weaning in mechanically ventilated organophosphate (OP)-poisoned patients as the primary outcomes while duration of mechanical ventilation (MV) support, intensive care unit (ICU), and hospital length of stay (LOS) and in-hospital mortali...

journal_title：Drug and chemical toxicology

authors： Abdel Hamid WG,Mansour W,Nafea OE

更新日期：2021-01-12 00:00:00

abstract：:The toxicity of etephon and maleic hydrazide, used as plant growth regulators in agriculture, were reported as low in mammals in previous studies. However, in vitro cytotoxicity studies in mammalian cells are currently missing to understand their toxicity at molecular level. In the current study, the cytotoxicity of t...

journal_title：Drug and chemical toxicology

authors： Yurdakok B,Baydan E,Okur H,Gurcan IS

更新日期：2014-10-01 00:00:00

abstract：:For centuries, Turkey has been a significant location here around 80 species of Hypericum with differing names widely occur, which is also known as Turkish folk medicine in treating some bacterial diseases as well as stomach and intestine inflammation. Recent studies have reported this herb family to contain numbers o...

journal_title：Drug and chemical toxicology

authors： Can S,Çetik Yıldız S,Keskin C,Şahintürk V,Cengiz M,Appak Başköy S,Ayhanci A,Akıncı G

更新日期：2020-12-06 00:00:00

abstract：:Experiments were carried out to ascertain whether or not saffron (dried stigmas of Crocus sativus L.), a commonly used agent for flavoring and coloring food can exert modulatory effects on the in vivo genotoxicity of cisplatin (CIS), cyclophosphamide (CPH), mitomycin C (MMC) and urethane (URE). For this purpose, Swiss...

journal_title：Drug and chemical toxicology

authors： Premkumar K,Abraham SK,Santhiya ST,Gopinath PM,Ramesh A

更新日期：2001-11-01 00:00:00

abstract：:The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and the National Oil and Hazardous Substances Pollution Contingency Plan (NCP) mandate protection of public health, welfare, and the environment at Superfund hazardous waste sites. The NCP requires lead response agenciesto integrate bas...

journal_title：Drug and chemical toxicology

authors： Fritz AT,Buchman MF

更新日期：1997-11-01 00:00:00

abstract：:During a preclinical safety evaluation study, an indication of ocular toxicity was noted in beagle dogs receiving orally (gelatin capsules) once a day, 7 days a week for, respectively, 7 and 91 days, 10 mg/kg/day of Lortalamine, a new non-tricyclic anti-depressant compound. Lortalamine treated dogs showed, progressive...

journal_title：Drug and chemical toxicology

authors： Mally C,Thiebault JJ

更新日期：1990-01-01 00:00:00