Abstract:
:Various chemical groups were evaluated for their skin sensitization potential in the guinea pig. In general, amines, acetanilides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further structural-related correlations or predictions should be made with caution due to variability of sample purity or differences in methodology. It is important to realize that every chemical which is positive in the guinea pig should not be construed as definitive evidence of human skin sensitization.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Rao KS,Betso JE,Olson KJdoi
10.3109/01480548109017825subject
Has Abstractpub_date
1981-01-01 00:00:00pages
331-51issue
4eissn
0148-0545issn
1525-6014journal_volume
4pub_type
杂志文章abstract::Genotoxicity of nimesulide (NM) was evaluated by employing bone marrow (BM) chromosomal aberration (CA) and micronucleus assays in Swiss albino mice. For BM CA assay, mice of either sex were treated orally with 1.5, 2.5 and 5 mg body weight solution of NM in 0.2 mL of 0.05% CMC (carboxy methyl cellulose) daily for 4, ...
journal_title:Drug and chemical toxicology
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