Sublethal effects of organophosphate diazinon on the brain of Cyprinus carpio.

abstract：:Neurodegenerative diseases affect millions of people. Major reasons behind the onset and progression of these diseases are still under investigation. Therefore, any approach that would treat/prevent progression is important. In this study, we aimed to investigate the potential protective effects of Psephellus pyrrhobl...

journal_title：Drug and chemical toxicology

authors： Taştan P,Armagan G,Dağcı T,Kıvçak B

更新日期：2019-09-02 00:00:00

abstract：:Rotenone, an environmental toxin, triggers Parkinson's disease (PD)-like pathology through microglia-mediated neuronal death. The effects and molecular mechanisms of flavonoid luteolin against rotenone-induced toxicity was assessed in microglial BV2 cells. Cells were pretreated with luteolin (1-50 µM) for 12 h and the...

journal_title：Drug and chemical toxicology

authors： Elmazoglu Z,Yar Saglam AS,Sonmez C,Karasu C

更新日期：2020-01-01 00:00:00

abstract：:This study evaluated the tissue distribution of total radioactivity in male albino, male pigmented, and time-mated female albino rats after oral administration of a single dose of [¹⁴C]-bilastine (20 mg/kg). Although only 1 animal was analyzed at each time point, there were apparent differences in bilastine distributi...

journal_title：Drug and chemical toxicology

authors： Lucero ML,Patterson AB

更新日期：2012-06-01 00:00:00

abstract：:In 1994, the United States Environmental Protection Agency (USEPA) developed a screening methodology for conducting indirect exposure risk assessments for combustion facilities. The United States Army Center for Health Promotion and Preventive Medicine currently utilizes this methodology in conjunction with other USEP...

journal_title：Drug and chemical toxicology

authors： Walter MA

更新日期：1999-02-01 00:00:00

abstract：:Modafinil is used for the treatment of various sleep disorders; however, its usage among healthy individuals is also increasing. There are a limited number of cardiovascular side effects, including ischemic T-wave changes, dyspnea, hypertension, and tachycardia in the literature. Our research aimed to investigate the ...

journal_title：Drug and chemical toxicology

authors： Canyurt D,Tanriverdi LH,Ozhan O,Cansel M,Parlakpinar H,Vardi N,Cigremis Y,Yildiz A,Karaca Y,Yasar S,Acet A

更新日期：2020-08-11 00:00:00

abstract：:As part of an occupational hazard evaluation, p-bromobenzyl bromide (p-BBB) was evaluated for genotoxic activity in the Ames microbial mutagenicity assay, the alkaline elution assay for DNA strand breaks in rat hepatocytes and the in vitro chromosome aberration assay in Chinese hamster ovary cells. The compound produc...

journal_title：Drug and chemical toxicology

authors： Sargent EV,Sina JF,Barnum JE,Storer RD,Johnson TE,Galloway SM,Prato MG,Kirsten NN,Naumann BD

更新日期：1999-11-01 00:00:00

abstract：:The effects of various levels of dietary iron on hepatic lipid peroxidation (malondialdehyde [MDA] content), reduced glutathione (GSH) and GSH peroxidase (GSH-PX) activity as well as liver and body weights of female rats following TCDD administration were examined. Rats were fed diets containing deficient (6 ppm), nor...

journal_title：Drug and chemical toxicology

authors： al-Turk WA,Shara MA,Mohammadpour H,Stohs SJ

更新日期：1988-01-01 00:00:00

abstract：:Three alkyl diamines, which are by-products formed and separated during the production of hexamethylene diamine, have been tested, mostly for their acute toxicity. This paper reviews methodologies used and the results obtained from these three chemicals. All three tested [2-methyl-1,5-pentanediamine (2-MP), 1,3-diamin...

journal_title：Drug and chemical toxicology

authors： Kennedy GL Jr

更新日期：2007-01-01 00:00:00

abstract：:Hexachloroethane (HCE) was fed to Fischer 344 rats at approximate doses of 0, 1, 15 or 62 mg/kg/day for 16 weeks. Selected tissues were assayed at termination for HCE content. Histopathological examination identified the kidney as the primary target organ with male rats more sensitive than female rats. The kidney conc...

journal_title：Drug and chemical toxicology

authors： Gorzinski SJ,Nolan RJ,McCollister SB,Kociba RJ,Mattsson JL

更新日期：1985-01-01 00:00:00

abstract：:An anti-tumor agent, the cationic dye rhodamine 123 (Rh 123), becomes concentrated in mitochondria of certain tissues and inhibits ATP production. Rh 123 was tested for developmental toxicity by i.p. injection into pregnant CD-1 mice daily on gestation days 7-10 (plug = day 1) at doses up to 15 mg/kg/day. Additional m...

journal_title：Drug and chemical toxicology

authors： Hood RD,Ranganathan S,Jones CL,Ranganathan PN

更新日期：1988-01-01 00:00:00

abstract：:The nicotine metabolism of CYP2A6 (CYP2A6*1A,*1B, and *1C), and the cholecystokinin (CCK; which modulates the release of dopamine) and CCK-A receptor gene and personality traits for NEO-FFI, was investigated for the mechanism for elucidation of the smoking behavior in Japanese populations. The frequency of the CYP2A6*...

journal_title：Drug and chemical toxicology

authors： Iwahashi K,Aoki J

更新日期：2009-01-01 00:00:00

abstract：:The effect of a novel phosphorothionate, the methyl ester of 2-butenoic acid-3-diethoxy phosphinothioyl (RPR-II) was studied on membrane bound target enzymes Acid (AcP) and Alkaline (AkP) Phosphatases in different tissues of male and female albino Wistar rats. Three sub-chronic doses 0.014 (low), 0.028 (medium) and 0....

journal_title：Drug and chemical toxicology

authors： Rahman MF,Siddiqui MK,Jamil K

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:The present study was undertaken to explore the effects of monensin, a potent Golgi disturbing agent on male fertility. METHODS:Male Wistar rats were administered monensin at the dose levels of 2.5, 5, and 10 mg/kg b wt. Animals were sacrificed after 67 days of the treatment. The activities of lactate dehydr...

journal_title：Drug and chemical toxicology

authors： Singh M,Kalla NR,Sanyal SN

更新日期：2014-10-01 00:00:00

abstract：CONTEXT:Heparin-binding epidermal growth factor like growth factor (HB-EGF) is an emerging therapeutic for the regeneration of the tympanic membrane (TM). OBJECTIVE:Our aim was to determine whether the doses of HB-EGF delivered in a sustained release hydrogel into a middle ear mouse model, would be measurable in the s...

journal_title：Drug and chemical toxicology

authors： Santa Maria PL,Kim S,Yang YP

更新日期：2016-10-01 00:00:00

abstract：:We investigated antigenotoxic and antioxidative effects of newly derivatized compound naringenin-oxime (NG-Ox) compared to its mother compound naringenin (NG) against oxidative damage induced by hydrogen peroxide (HP) in human peripheral blood mononuclear cells (PBMC). Antigenotoxic activity was assessed using alkalin...

journal_title：Drug and chemical toxicology

authors： Kocyigit A,Koyuncu I,Taskin A,Dikilitas M,Bahadori F,Turkkan B

更新日期：2016-01-01 00:00:00

abstract：:The accelerating rotarod was used to assess motor performance decrement in rats after administration of candidate anticonvulsant compounds (acetazolamide, amitriptyline, chlordiazepoxide, diazepam, diazepam-lysine, lorazepam, loprazolam, midazolam, phenobarbital and scopolamine) against nerve agent poisoning. All comp...

journal_title：Drug and chemical toxicology

authors： Capacio BR,Harris LW,Anderson DR,Lennox WJ,Gales V,Dawson JS

更新日期：1992-01-01 00:00:00

abstract：:A Type II pyrethroid pesticide β-cypermethrin is widely used in agriculture and domestic applications for pest control. However, the effect of β-cypermethrin on the glutamate neurotransmitter has not been well-documented. In the current study, mice were treated with 20, 40, or 80 mg/kg β-cypermethrin by a single oral ...

journal_title：Drug and chemical toxicology

authors： Cao D,Chen N,Zhu C,Zhao Y,Liu L,Yang J,An L

更新日期：2015-01-01 00:00:00

abstract：:Many steps are required to convert a normal cell into a cancerous one. The cancer cell must be able to multiply under conditions that a normal cell would not and to invade surrounding tissue and spread throughout the body. Both genetic changes, such as activation of oncogenes or inactivation of tumor suppressor genes,...

journal_title：Drug and chemical toxicology

authors： Couch DB

更新日期：1996-08-01 00:00:00

abstract：:The immunomodulatory effects of two plant regulators, cycloheximide and maleic hydrazide, were investigated by injecting the compounds twice weekly for 4 weeks in female Swiss Webster white mice. The animals were antigenically challenged with sheep red blood cells on day 24 of the study. Although humoral immunity was ...

journal_title：Drug and chemical toxicology

authors： Olson LJ,Hinsdill RD,Weltman DJ

更新日期：1983-01-01 00:00:00

abstract：:Aluminum (Al)-induced toxicity in fruit fly (Drosophila melanogaster) is one of the established models for studying neurotoxicity and neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, the aim of this study is to determine the effect of alkaloid extrac...

journal_title：Drug and chemical toxicology

authors： Adedayo BC,Ogunsuyi OB,Akinniyi ST,Oboh G

更新日期：2020-01-03 00:00:00

abstract：:A comparison of the fertility and cytogenetic analyses and the combination of both techniques as generally used in the heritable translocation assay was conducted with triethylenemelamine (TEM). CD-1 mice were used as the F0 generation and were divided into two groups that received i.p. either distilled water (control...

journal_title：Drug and chemical toxicology

authors： Moreland FM,Sheu CJ

更新日期：1983-01-01 00:00:00

abstract：:A series of new compounds were evaluated for acute in vivo toxicity. Their synthesis and antifungal activity have previously been described by us. The naturally occurring class of compounds to which they belong - the benzylidenechroman-4-ones - have been identified as a potential source of new antifungal agents. These...

journal_title：Drug and chemical toxicology

authors： Al-Nakib TM,Miller NJ,Rashid S,Meegan MJ

更新日期：1990-01-01 00:00:00

abstract：:Amiodarone is a high effectiveness anti-arrhythmia agent which is able to induce pulmonary fibrosis. Many studies have shown that the epithelial-mesenchymal transition (EMT) was a significant process in pulmonary fibrosis. So far, there are no studies about whether EMT was associated with amiodarone-induced pulmonary ...

journal_title：Drug and chemical toxicology

authors： Weng J,Chen H,Wu H,Tu M,Wang Z,Chen D,Wang Z,Chen C

更新日期：2020-07-01 00:00:00

abstract：:Various antioxidants play an important role in reducing the reactive oxygen species (ROS) by scavenging them directly or indirectly. Mercury (Hg) is one of the known hazardous genotoxicant, induces the genotoxicity by enhancing the ROS. In the present study, three structurally different bioactive compounds such as mel...

journal_title：Drug and chemical toxicology

authors： Patel TA,Rao MV

更新日期：2015-10-01 00:00:00

abstract：:The quantities of selenium, tar and nicotine present in mainstream (MS) and sidestream (SS) smoke of machine-smoked cigarettes was studied. The cigarettes were prepared from tobacco purposely cultured on fly ash-amended soil so as to increase its selenium concentration. Selenium concentration was found to be the same ...

journal_title：Drug and chemical toxicology

authors： Gutenmann WH,Lisk DJ,Shane BS,Hoffmann D,Adams JD

更新日期：1987-01-01 00:00:00

abstract：:Several studies documented the ameliorative effects of curcumin which plays a pivotal role in radical scavenging activities. It also participates in various cellular pathways and interacts with multiple targets. In the present study, we investigated the ameliorative effect of curcumin upon chromosomal genotoxicity ind...

journal_title：Drug and chemical toxicology

authors： Shah AJ,Prasanth Kumar S,Rao MV,Pandya HA

更新日期：2018-07-01 00:00:00

abstract：:Exposure to crude acetylene can occur in occupational settings. This study assessed the modulatory activities of selected polyphenols on the hematotoxic, cardiotoxic, and hepatotoxic effects of crude acetylene. Wistar rats were exposed to 58 000 ppm crude acetylene for 10 min at 12 h intervals for 30 days. Some expose...

journal_title：Drug and chemical toxicology

authors： Aladesanmi OO,Akinmoladun AC,Josiah SS,Olaleye MT,Akindahunsi AA

更新日期：2020-12-08 00:00:00

abstract：:Chemical pretreatment is effective against a 2 LD50 challenge of soman, sarin or VX or a 5 LD50 challenge of tabun. Chemical pretreatment followed by post challenge therapy should be effective against greater levels of agent. Such tests in guinea pigs are reported here; pretreatment regimens (PRGs) consisted of physos...

journal_title：Drug and chemical toxicology

authors： Lennox WJ,Harris LW,Anderson DR,Solana RP,Murrow ML,Wade JV

更新日期：1992-01-01 00:00:00

abstract：:Understanding the mechanism behind neuronal regeneration is critical for treating ischemic stroke and traumatic brain injury. The presence of neural stem cells in and around the sub-ventricular zone of human and also in zebrafish is evidenced. In this current study, the neuro-protective potential of nano-formulated he...

journal_title：Drug and chemical toxicology

authors： Paramita P,Sethu SN,Subhapradha N,Ragavan V,Ilangovan R,Balakrishnan A,Srinivasan N,Murugesan R,Moorthi A

更新日期：2020-02-12 00:00:00

abstract：:Oxidative stress is produced under diabetic conditions and is likely involved in the progression of pancreatic damage found in diabetes. This study was undertaken to evaluate the protective effect of Aegle marmelos leaf extract, a medicinal plant, on the tissue antioxidant defense system and lipid peroxidative status ...

journal_title：Drug and chemical toxicology

authors： Narendhirakannan RT,Subramanian S

更新日期：2010-04-01 00:00:00