Abstract:
:A series of new compounds were evaluated for acute in vivo toxicity. Their synthesis and antifungal activity have previously been described by us. The naturally occurring class of compounds to which they belong - the benzylidenechroman-4-ones - have been identified as a potential source of new antifungal agents. These compounds were found to be less toxic, as judged by acute toxicity, than existing commercially available antifungals. A number of conclusions can be drawn about the relationship of structural changes in this series of compounds to increases or decreases in acute toxicity.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Al-Nakib TM,Miller NJ,Rashid S,Meegan MJdoi
10.3109/01480549009018120subject
Has Abstractpub_date
1990-01-01 00:00:00pages
195-207issue
2-3eissn
0148-0545issn
1525-6014journal_volume
13pub_type
杂志文章abstract::Chrysin (CH) is a natural flavone which possesses antioxidant, anti-cancer, and anti-inflammatory properties. The aim of the present study was to investigate the effects of CH on biochemical parameters, histopathological changes, and genotoxicity and hematological indices in diazinon (DZN)-induced toxicity in BALB/c m...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2017.1384834
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abstract::The responses of atria isolated from four groups of rats: (a) control (air/H2O) and test animals treated with (b) 5 PPM nitrogen dioxide NO2 for 72 hours, (NO2/H2O), (c) 10% ethanol (ET) in water for 13 days, (air/ET), or (d) combination of NO2 and ET (NO2/ET). Isolated atria were tested with norepinephrine and dose r...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548309017818
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pub_type: 杂志文章
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更新日期:2020-01-03 00:00:00
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
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更新日期:1999-02-01 00:00:00
abstract::Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaco...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1586916
更新日期:2019-03-21 00:00:00
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549809002204
更新日期:1998-08-01 00:00:00
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Drug and chemical toxicology
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更新日期:1987-01-01 00:00:00
abstract:INTRODUCTION:Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) proteins including collagen that occurs in most types of chronic liver diseases. This study aimed to investigate and compare the therapeutic efficacy of different magnesium (Mg)-containing supplements (formulations A, B, and C) on c...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2016.1172083
更新日期:2017-01-01 00:00:00
abstract::For centuries, Turkey has been a significant location here around 80 species of Hypericum with differing names widely occur, which is also known as Turkish folk medicine in treating some bacterial diseases as well as stomach and intestine inflammation. Recent studies have reported this herb family to contain numbers o...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1856130
更新日期:2020-12-06 00:00:00
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
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更新日期:2019-06-14 00:00:00
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Drug and chemical toxicology
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doi:10.1080/01480545.2019.1696813
更新日期:2019-12-02 00:00:00
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548409042817
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journal_title:Drug and chemical toxicology
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doi:10.3109/01480548109017825
更新日期:1981-01-01 00:00:00
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480540903580055
更新日期:2010-10-01 00:00:00
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章,评审
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更新日期:2002-11-01 00:00:00
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
abstract::Cisplatin-induced nephrotoxicity is closely associated with an increase in lipid peroxidation. In several previous reports it was claimed that acetylsalicylic acid (ASA) shows its therapeutic potential as a free radical scavenger. The aim of the study was to investigate effects of ASA on cisplatin induced nephrotoxici...
journal_title:Drug and chemical toxicology
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更新日期:2003-11-01 00:00:00
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journal_title:Drug and chemical toxicology
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更新日期:2020-01-01 00:00:00
abstract::Tempol (4-hydroxy tempo), a pleiotropic antioxidant is reported to afford protection against cisplatin (CP)-induced nephrotoxicity. However, molecular mechanisms of action of tempol in improving the renal function in CP-induced nephrotoxicity are not fully understood. We investigated the attenuating effect of tempol a...
journal_title:Drug and chemical toxicology
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更新日期:2020-10-20 00:00:00
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journal_title:Drug and chemical toxicology
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更新日期:1988-01-01 00:00:00
abstract::As part of an occupational hazard evaluation, p-bromobenzyl bromide (p-BBB) was evaluated for genotoxic activity in the Ames microbial mutagenicity assay, the alkaline elution assay for DNA strand breaks in rat hepatocytes and the in vitro chromosome aberration assay in Chinese hamster ovary cells. The compound produc...
journal_title:Drug and chemical toxicology
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更新日期:1999-11-01 00:00:00
abstract::In view of the ability of several phosphoesterases to hydrolyze organophosphates to toxic phenols, the bioactivation of bis[p-nitrophenyl]phosphate (BNPP) by the earthworm Lumbricus terrestris was investigated. In a contact toxicity test, BNPP was was less toxic than the metabolite p-nitrophenol (PNP), but more toxic ...
journal_title:Drug and chemical toxicology
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更新日期:1993-01-01 00:00:00