Ameliorative effect of certain antioxidants against mercury induced genotoxicity in peripheral blood lymphocytes.

abstract：:This study was conducted to evaluate the potential reproductive toxicity of epichlorohydrin in a one-generation reproduction toxicity study in compliance with OECD Test Guideline 415. Twenty-four male and female rats per group were given epichlorohydrin by gavage at 0, 3.3, 10, and 30 mg/kg/day. Males were dosed for 1...

journal_title：Drug and chemical toxicology

authors： Shin IS,Park NH,Lee JC,Kim KH,Moon C,Kim SH,Shin DH,Park SC,Kim HY,Kim JC

更新日期：2010-07-01 00:00:00

abstract：:The effects of feeding two compounds, dehydroepiandrosterone (DHEA), an adrenal steroid, and clofibrate (CLOF) to rats (which are both hypolipidemic, hepatomegaly inducing and hepatic peroxisome proliferating agents) on the binding of 7,12-dimethylbenz(a)anthracene (DMBA) to hepatic DNA in vivo is compared. Male Sprag...

journal_title：Drug and chemical toxicology

authors： Prasanna HR,Hart RW,Magee PN

更新日期：1989-09-01 00:00:00

abstract：:The median lethal dose (LD50) of chymopapain B in mice was 82 mg/kg (22,000 units/kg) with 95% confidence limits of 75-90 mg/kg (20, 122-24, 146 units/kg) and in rats 92 (24,683 units/kg) with 95% confidence limits of 83-102 mg/kg (22,268-27, 366 units/kg). The mechanism of toxicity was hemorrhage due to destruction o...

journal_title：Drug and chemical toxicology

authors： Simmons JW,Upman PJ,Stavinoha WB

更新日期：1984-01-01 00:00:00

abstract：:This study was designed to investigate possible interference of Xenobiotics with SUMOylation in eukaryotic cells. To begin with, we docked 71 chemical structures from PubChem with human SUMO1 and UBC9 protein structures using Auto Dock 4.2 and Hex 6.3 and selected five compounds for binding studies in Surface Plasmon ...

journal_title：Drug and chemical toxicology

authors： Yarahalli Jayaram V,Baggavalli S,Reddy D,Sistla S,Malempati R

更新日期：2020-11-01 00:00:00

abstract：:The accelerating rotarod was used to assess motor performance decrement in rats after administration of candidate anticonvulsant compounds (acetazolamide, amitriptyline, chlordiazepoxide, diazepam, diazepam-lysine, lorazepam, loprazolam, midazolam, phenobarbital and scopolamine) against nerve agent poisoning. All comp...

journal_title：Drug and chemical toxicology

authors： Capacio BR,Harris LW,Anderson DR,Lennox WJ,Gales V,Dawson JS

更新日期：1992-01-01 00:00:00

abstract：:The disposition of N-[14C-vinyl]-2-pyrrolidinone was studied in male Sprague-Dawley rats following a single iv injection. Plasma levels of the intact compound dropped rapidly within the first 6 hours after dosing with a half life of 1.90 hours. Urinary excretion by 12 hours represented 74.9% of a 5 microCi dose while ...

journal_title：Drug and chemical toxicology

authors： McClanahan JS,Lin YC,Digenis GA

更新日期：1984-01-01 00:00:00

abstract：:In a chronic toxicity study in the rat, bidisomide administered as a dietary admixture produced a dose-related lowering of reticulocytes and leucocytes. Plasma alanine aminotransferase activity was increased at 300 mg/kg and decreased at 900 mg/kg. The potential mechanisms of these effects were investigated by compari...

journal_title：Drug and chemical toxicology

authors： Vandenberghe Y,Masson M,Palate B,Roba J

更新日期：1995-11-01 00:00:00

abstract：:Concerns that chemical warfare (CW) agents themselves or in combination with other chemicals may cause long-term damage to nerve and muscle are reviewed and discussed. Experiments on mice and hens underway with agent GA and pyridostigmine bromide (PB) and their effects (either separately or together) are presented. ...

journal_title：Drug and chemical toxicology

authors： Wilson BW,Henderson JD,Spencer PS

更新日期：1998-01-01 00:00:00

abstract：:Polypeptide antibiotics, such as polymyxins and aminoglycosides, are essential for treatment of life-threatening Gram-negative infections. Acute kidney injury (AKI) attributed to treatment with these agents severely limits their clinical application. Because standard biomarkers (serum creatinine [sCRE] and blood urea ...

journal_title：Drug and chemical toxicology

authors： Burt D,Crowell SJ,Ackley DC,Magee TV,Aubrecht J

更新日期：2014-04-01 00:00:00

abstract：:Three trials involving 184 male Sprague Dawley rats were conducted to identify the biologically active fraction of endophyte-infected tall fescue seed. In trial 1, seed infected (greater than 95%) with the endophytic fungus Acremonium coenophialum and shown to be toxic to cattle, was serially extracted with hexane, et...

journal_title：Drug and chemical toxicology

authors： Jackson JA,Hemken RW,Bush LP,Boling JA,Siegel MR,Zavos PM

更新日期：1987-01-01 00:00:00

abstract：:Adriamycin (ADR) causes morphological and functional alterations in mitochondrial structure in the heart. The study's aim was to determine whether there is a protective effect of selenium (Se) on ADR-induced cardiac damage. Rats were divided into four groups: The first group was injected saline intraperitoneally (i.p....

journal_title：Drug and chemical toxicology

authors： Dursun N,Taşkın E,Yerer Aycan MB,Sahin L

更新日期：2011-04-01 00:00:00

abstract：:Endophytic fungi are promising sources of bioactive substances; however, their secondary metabolites are toxic to plants, animals, and humans. This study aimed toevaluate the toxic, cytotoxic, mutagenic and oxidant/antioxidant activities of acetonitrile extract (AEPc), citrinin (CIT) and dicitrinin-A (DIC-A) of Penici...

journal_title：Drug and chemical toxicology

authors： de Oliveira Filho JWG,Andrade TJADS,de Lima RMT,Silva DHS,Dos Reis AC,Santos JVO,de Meneses APM,de Carvalho RM,da Mata AMO,de Alencar MVOB,Dias ACS,da Silva FCC,Islam MT,Clark CCT,Sousa JMCE,Melo-Cavalcante AAC

更新日期：2020-05-25 00:00:00

abstract：:In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were administered to the rats for 1 week. Serum biochemical cardiotoxicity parameters and tissue malond...

journal_title：Drug and chemical toxicology

authors： Saraçoğlu A,Temel HE,Ergun B,Colak O

更新日期：2009-01-01 00:00:00

abstract：:Methyl 2,2-difluoromalonyl fluoride (MMF) is highly toxic by inhalation producing mortality in rats exposed for 4 hours to 0.55 mg/L. Repeated inhalation exposures of rats to 0.009 mg/L produced irritation but no other signs of a toxic response. Mortality was encountered following repeated exposures to 0.066 mg/L. ...

journal_title：Drug and chemical toxicology

authors： Kennedy GL Jr,Burgess BA,Chen HC

更新日期：1988-06-01 00:00:00

abstract：:The effect of chlormethiazole (CMZ) at single and multiple doses on the toxicokinetics of diethylnitrosamine (DEN) was investigated in normal rats and those with DEN-induced liver fibrosis. Twelve rats were treated with DEN (50 mg/kg) alone and in combination with a single dose of CMZ (10, 50, or 100 mg/kg) by intrape...

journal_title：Drug and chemical toxicology

authors： Wang G,Xiao K,Gao J,Jiang S,Wang S,Weng S,Xu C,Wang T,Qiao HL

更新日期：2019-11-01 00:00:00

abstract：:Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaco...

journal_title：Drug and chemical toxicology

authors： Ye Q,Liu H,Fang C,Liu Y,Liu X,Liu J,Zhang C,Zhang T,Peng C,Guo L

更新日期：2019-03-21 00:00:00

abstract：:Male Sprague-Dawley rats were administered cadmium chloride 0, 50, 100, 150 and 200 ppm for 30 days. At the end of the treatments, the body weight gains, serum glucose, serum protein, serum glutamic oxalacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were determined. Renal and hepatic key glu...

journal_title：Drug and chemical toxicology

authors： Chapatwala KD,Rajanna B,Desaiah D

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Parkinsonism describes Parkinson's disease and other associated degenerative changes in the brain resulting in movement disorders. The motor cortex, extrapyramidal tracts and nigrostriatal tract are brain regions forming part of the motor neural system and are primary targets for drug or chemotoxins induced ...

journal_title：Drug and chemical toxicology

authors： Ogundele OM,Nanakumo ET,Ishola AO,Obende OM,Enye LA,Balogun WG,Cobham AE,Abdulbasit A

更新日期：2015-10-01 00:00:00

abstract：:Suppression of mitogen-induced splenocyte lymphoproliferation and interleukin 2 (IL-2) production can be used as indicators of immunotoxicity. Staphylococcal enterotoxin A (SEA) is both a potent mitogen and the most potent in vitro inducer of IL-2 production that has been described. An in vitro system was used to meas...

journal_title：Drug and chemical toxicology

authors： Reid LL,Hastings KL,Gandolfi AJ,Van Ert M

更新日期：1994-01-01 00:00:00

abstract：CONTEXT:Caffeine is the most widely consumed nervous stimulant that induces oxidative-mediated apoptosis and cell cycle arrest in neural cells. Due to low toxicity, high accumulation in neural cells, reduction of the free fatty acids and antioxidant property, l-carnitine (LC) is an interesting compound to be used in vi...

journal_title：Drug and chemical toxicology

authors： Bavari M,Tabandeh MR,Najafzadeh Varzi H,Bahramzadeh S

更新日期：2016-01-01 00:00:00

abstract：:2-Amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine (ACCPE) is a water soluble compound formed during the alkaline treatment of the alcoholic liquor in the production of 2-chlorobenzylidene malononitrile (CS). The acute toxicity and primary irritancy of ACCPE and CS were investigated and compared. Both perorally and...

journal_title：Drug and chemical toxicology

authors： Ballantyne B

更新日期：1985-01-01 00:00:00

abstract：:Cis-1,2-dichloroethylene was administered daily by corn oil gavage to male and female Sprague-Dawley rats at the following dose levels: 1.0, 3.0, 10.0 and 22.0 mmol/kg/day for 14 days. Doses gavaged during the 90-day subchronic study were 0.33, 1.00, 3.00 and 9.00 mmol/kg/day. There were no compound-related deaths or ...

journal_title：Drug and chemical toxicology

authors： McCauley PT,Robinson M,Daniel FB,Olson GR

更新日期：1995-05-01 00:00:00

abstract：:Phospholipidosis is the excessive accumulation of intracellular phospholipids in cell lysosomes. Drugs that induce this disease often share common physiochemical properties and are collectively classified as cationic amphiphilic drugs (CADs). Although the cause of phospholipidosis and morphologic appearance of affecte...

journal_title：Drug and chemical toxicology

authors： Piccotti JR,LaGattuta MS,Knight SA,Gonzales AJ,Bleavins MR

更新日期：2005-01-01 00:00:00

abstract：:An anti-tumor agent, the cationic dye rhodamine 123 (Rh 123), becomes concentrated in mitochondria of certain tissues and inhibits ATP production. Rh 123 was tested for developmental toxicity by i.p. injection into pregnant CD-1 mice daily on gestation days 7-10 (plug = day 1) at doses up to 15 mg/kg/day. Additional m...

journal_title：Drug and chemical toxicology

authors： Hood RD,Ranganathan S,Jones CL,Ranganathan PN

更新日期：1988-01-01 00:00:00

abstract：:Toxic fungal metabolites - mycotoxins - cause poisonings after consumption of contaminated food commodities. The most probable intoxications are connected with eating poorly stored food or inhaling of moldy dust. One of the effective ways to protect people against mycotoxins is timely detection. Several methods such a...

journal_title：Drug and chemical toxicology

authors： Pohanka M,Jun D,Kuca K

更新日期：2007-01-01 00:00:00

abstract：:The potential genotoxic effect of venlafaxine hydrochloride (venlafaxine), an antidepressant drug-active ingredient, was investigated by using in vitro chromosome aberrations (CAs) and cytokinesis-block micronucleus (CBMN) assays in human peripheral blood lymphocytes (PBLs). Mitotic index (MI) and cytokinesis-block pr...

journal_title：Drug and chemical toxicology

authors： Ayabaktı S,Yavuz Kocaman A

更新日期：2020-03-01 00:00:00

abstract：:Orlistat is an FDA-approved over-the-counter drug to treat obesity through the inhibition of lipase activity. Macrophages, which express high levels of lipoprotein lipase (LPL), are important phagocytes in the innate immune system. Our previous studies indicated that environmentally relevant concentrations of arsenite...

journal_title：Drug and chemical toxicology

authors： Lou K,Huang P,Ma H,Wang X,Xu H,Wang W

更新日期：2019-10-31 00:00:00

abstract：:Given the increasing prevalence of occupational sensitization to acrylate compounds, n-butyl acrylate (BAC), ethyl acrylate (EAC), and trimethylol propane triacrylate (TMT) were recommended by the National Toxicology Program for hypersensitivity testing in female B6C3F1 mice. The objectives of these studies were to de...

journal_title：Drug and chemical toxicology

authors： Hayes BB,Meade BJ

更新日期：1999-08-01 00:00:00

abstract：:Understanding the mechanism behind neuronal regeneration is critical for treating ischemic stroke and traumatic brain injury. The presence of neural stem cells in and around the sub-ventricular zone of human and also in zebrafish is evidenced. In this current study, the neuro-protective potential of nano-formulated he...

journal_title：Drug and chemical toxicology

authors： Paramita P,Sethu SN,Subhapradha N,Ragavan V,Ilangovan R,Balakrishnan A,Srinivasan N,Murugesan R,Moorthi A

更新日期：2020-02-12 00:00:00

abstract：:While it is well recognized that the combination of amoxicillin and clavulanic acid has been associated with hepatic adverse events, there are only a few reports about amoxicillin alone causing hepatic toxicity. We describe a 34-year-old woman who developed severe cholestatic hepatitis following amoxicillin treatment....

journal_title：Drug and chemical toxicology

authors： Chaabane NB,Safer L,Njim L,Zakhama A,Saffar H

更新日期：2011-10-01 00:00:00