Abstract:
:2-Amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine (ACCPE) is a water soluble compound formed during the alkaline treatment of the alcoholic liquor in the production of 2-chlorobenzylidene malononitrile (CS). The acute toxicity and primary irritancy of ACCPE and CS were investigated and compared. Both perorally and intravenously, ACCPE was significantly less acutely toxic than CS. Also, whilst CS was a moderate dermal and eye irritant, ACCPE was not a primary skin irritant and only marginally irritating to the eye. ACCPE presents a significantly lower acute handling hazard than does CS.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Ballantyne Bdoi
10.3109/01480548508999168subject
Has Abstractpub_date
1985-01-01 00:00:00pages
171-82issue
3eissn
0148-0545issn
1525-6014journal_volume
8pub_type
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journal_title:Drug and chemical toxicology
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