Cytogenotoxic evaluation of the acetonitrile extract, citrinin and dicitrinin-A from Penicillium citrinum.

abstract：:In view of the ability of several phosphoesterases to hydrolyze organophosphates to toxic phenols, the bioactivation of bis[p-nitrophenyl]phosphate (BNPP) by the earthworm Lumbricus terrestris was investigated. In a contact toxicity test, BNPP was was less toxic than the metabolite p-nitrophenol (PNP), but more toxic ...

journal_title：Drug and chemical toxicology

authors： Park SC,Smith TJ,Bisesi MS

更新日期：1993-01-01 00:00:00

abstract：:In the subchronic study acrylic acid was incorporated in the drinking water of Fischer 344 rats (15 per group) for three months at dosage levels of 0.75, 0.25, 0.083 or 0 g/kg/day. No deaths occurred during the study but several treatment-related effects were observed. At 0.75 g/kg/day dosage level, body weight gain w...

journal_title：Drug and chemical toxicology

authors： DePass LR,Woodside MD,Garman RH,Weil CS

更新日期：1983-01-01 00:00:00

abstract：:Butea monosperma (Lam.) Taub. is an ethnomedicinal tree of remedial value in the treatment of diabetes, bone fractures, and liver and neurological disorders. However, the information available on DNA-protective and anti-proliferative potential of bark of this tree is scarce. In the present study, the extract/fractions...

journal_title：Drug and chemical toxicology

authors： Kaur V,Kumar M,Kumar A,Kaur S

更新日期：2020-07-01 00:00:00

abstract：:For centuries, Turkey has been a significant location here around 80 species of Hypericum with differing names widely occur, which is also known as Turkish folk medicine in treating some bacterial diseases as well as stomach and intestine inflammation. Recent studies have reported this herb family to contain numbers o...

journal_title：Drug and chemical toxicology

authors： Can S,Çetik Yıldız S,Keskin C,Şahintürk V,Cengiz M,Appak Başköy S,Ayhanci A,Akıncı G

更新日期：2020-12-06 00:00:00

abstract：BACKGROUND:Plasmodium yoelii nigeriensis (P. y. nigeriensis) produces lethal malaria infection in Swiss albino mice. Reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide along with endogenously produced tumor necrosis factor (TNF) have been implicated in the pathogenesis of malaria. OBJECTIVE:Stud...

journal_title：Drug and chemical toxicology

authors： Siddiqi NJ,Alhomida AS,Sharma B,Pandey VC

更新日期：2000-11-01 00:00:00

abstract：:S-[3-carbamoylsulfanyl-2-(dimethylamino)propyl] carbamothioate (Cartap) (CAS number: 15263-52-2) is a synthetic insecticide of thiocarbamates group that is extensively used in field of agriculture for controlling of several pests like rice stem borer, leaf folder pests in paddy field and diamond back moth, aphids in c...

journal_title：Drug and chemical toxicology

authors： Sharma LP,Kadve MP,Lingaraju MC,Telang AG

更新日期：2021-03-01 00:00:00

abstract：:Three trials involving 184 male Sprague Dawley rats were conducted to identify the biologically active fraction of endophyte-infected tall fescue seed. In trial 1, seed infected (greater than 95%) with the endophytic fungus Acremonium coenophialum and shown to be toxic to cattle, was serially extracted with hexane, et...

journal_title：Drug and chemical toxicology

authors： Jackson JA,Hemken RW,Bush LP,Boling JA,Siegel MR,Zavos PM

更新日期：1987-01-01 00:00:00

abstract：:The genotoxic effect of CBZ has been investigated in few studies. There is little evidence linking carbamazepine (CBZ) with any genotoxic effects, particularly in vitro micronucleus test using cytogenesis-block technique. In this study, the genotoxicity of the antiepileptic drug, carbamazepine, was tested using cytoki...

journal_title：Drug and chemical toxicology

authors： Celik A

更新日期：2006-01-01 00:00:00

abstract：:The developmental toxicities of five test compounds including carbon tetrachloride, urethane, phenacetin, parathion, and chloroform, were evaluated using Frog Embryo Teratogenesis Assay--Xenopus (FETAX), with minor modification. Post-isolation mixtures of differently-induced rat liver microsomes (phenobarbital- (PB), ...

journal_title：Drug and chemical toxicology

authors： Fort DJ,Rogers RL,Paul RR,Stover EL,Finch RA

更新日期：2001-05-01 00:00:00

abstract：:Male Sprague-Dawley rats were administered cadmium chloride 0, 50, 100, 150 and 200 ppm for 30 days. At the end of the treatments, the body weight gains, serum glucose, serum protein, serum glutamic oxalacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were determined. Renal and hepatic key glu...

journal_title：Drug and chemical toxicology

authors： Chapatwala KD,Rajanna B,Desaiah D

更新日期：1980-01-01 00:00:00

abstract：:Beagle dogs (3 to 6 years old) were treated with 100-150 mg procainamide HC1/kg/day. After 2, 5, and 9 months of treatment, peripheral blood lymphocytes were isolated and stimulated with pokeweed mitogen. The data demonstrated a suppression of mitogenesis only at 2 and 5 months after procainamide treatment. The lympho...

journal_title：Drug and chemical toxicology

authors： Mulhern SA,Daguillard F,Robinson CJ,Balazs T

更新日期：1988-06-01 00:00:00

abstract：:The quantities of selenium, tar and nicotine present in mainstream (MS) and sidestream (SS) smoke of machine-smoked cigarettes was studied. The cigarettes were prepared from tobacco purposely cultured on fly ash-amended soil so as to increase its selenium concentration. Selenium concentration was found to be the same ...

journal_title：Drug and chemical toxicology

authors： Gutenmann WH,Lisk DJ,Shane BS,Hoffmann D,Adams JD

更新日期：1987-01-01 00:00:00

abstract：:The purpose of this research was to evaluate the efficacy of carsil (CAR) either alone or in combination with α-tocopherol (α-TOCO) and/or turmeric (TUMR) against tetrachloromethane (TCM)-induced cardiomyocyte injury in rats. Administration of CAR either alone or in combination with α-TOCO and/or TUMR post-TCM injecti...

journal_title：Drug and chemical toxicology

authors： Alshanwani AR,Faddah LM,Hagar H,Alhusaini AM,Shaheen S,Mohammad RA,Alharbi FMB,AlHarthii A,Badr AM

更新日期：2020-10-15 00:00:00

abstract：:The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and the National Oil and Hazardous Substances Pollution Contingency Plan (NCP) mandate protection of public health, welfare, and the environment at Superfund hazardous waste sites. The NCP requires lead response agenciesto integrate bas...

journal_title：Drug and chemical toxicology

authors： Fritz AT,Buchman MF

更新日期：1997-11-01 00:00:00

abstract：:Aluminum (Al)-induced toxicity in fruit fly (Drosophila melanogaster) is one of the established models for studying neurotoxicity and neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, the aim of this study is to determine the effect of alkaloid extrac...

journal_title：Drug and chemical toxicology

authors： Adedayo BC,Ogunsuyi OB,Akinniyi ST,Oboh G

更新日期：2020-01-03 00:00:00

abstract：:Oxidative stress is produced under diabetic conditions and is likely involved in the progression of pancreatic damage found in diabetes. This study was undertaken to evaluate the protective effect of Aegle marmelos leaf extract, a medicinal plant, on the tissue antioxidant defense system and lipid peroxidative status ...

journal_title：Drug and chemical toxicology

authors： Narendhirakannan RT,Subramanian S

更新日期：2010-04-01 00:00:00

abstract：:This study assessed possible adverse immunological effects of trans-1,2-dichloroethylene (DCE) on random-bred CD-1 mice following 14 and 90 days of exposure. A 14-day range-finding study was performed on male mice by gavage at doses 1/10 and 1/100 the LD50 (210 and 21 mg/kg). No alterations in either humoral or cell-m...

journal_title：Drug and chemical toxicology

authors： Shopp GM Jr,Sanders VM,White KL Jr,Munson AE

更新日期：1985-01-01 00:00:00

abstract：:The cytotoxic effect of caffeine on heart cells was evaluated in primary cultures of rat heart muscle (M) and endothelioid (E) cells. The cultures were exposed to 5, 10, or 20 mM caffeine for 6, 12, or 24 hours. As an index of cytotoxicity produced by the treatments, in situ changes in mitochondrial membrane fragility...

journal_title：Drug and chemical toxicology

authors： Acosta D,Anuforo D

更新日期：1977-01-01 00:00:00

abstract：:This study was designed to investigate possible interference of Xenobiotics with SUMOylation in eukaryotic cells. To begin with, we docked 71 chemical structures from PubChem with human SUMO1 and UBC9 protein structures using Auto Dock 4.2 and Hex 6.3 and selected five compounds for binding studies in Surface Plasmon ...

journal_title：Drug and chemical toxicology

authors： Yarahalli Jayaram V,Baggavalli S,Reddy D,Sistla S,Malempati R

更新日期：2020-11-01 00:00:00

abstract：:Transient global ischemia continues to be an important clinical problem with limited treatment options. The present study aimed to investigate the possible protective effects of celecoxib [a selective cyclooxygenase (COX-2) inhibitor] and N-omega-nitro-L-arginine methyl ester (L-NAME) [a nonselective nitric oxide synt...

journal_title：Drug and chemical toxicology

authors： Abd El-Aal SA,El-Sawalhi MM,Seif-El-Nasr M,Kenawy SA

更新日期：2013-10-01 00:00:00

abstract：:Cis-1,2-dichloroethylene was administered daily by corn oil gavage to male and female Sprague-Dawley rats at the following dose levels: 1.0, 3.0, 10.0 and 22.0 mmol/kg/day for 14 days. Doses gavaged during the 90-day subchronic study were 0.33, 1.00, 3.00 and 9.00 mmol/kg/day. There were no compound-related deaths or ...

journal_title：Drug and chemical toxicology

authors： McCauley PT,Robinson M,Daniel FB,Olson GR

更新日期：1995-05-01 00:00:00

abstract：:The cross-reaction patterns of selected acrylate and methacrylate esters were investigated using the guinea pig maximization test. Methacrylates were less potent sensitizers than acrylates. Cross-sensitization was found between (meth)acrylates with closely related core structures, most extensively between hydroxyethyl...

journal_title：Drug and chemical toxicology

authors： Clemmensen S

更新日期：1984-01-01 00:00:00

abstract：:In adult female Wistar rats, pretreated by gavage with two doses - 16 or 256 mumol/kg - of cyanamide, TMTD (tetramethylthiuram disulfide), TMTM (tetramethylthiuram monosulfide), Ziram or Zineb at 90 min or 18 h before administration of 2 g of ethanol/kg i.p., the blood acetaldehyde levels were significantly increased ...

journal_title：Drug and chemical toxicology

authors： García de Torres G,Römer KG,Torres Alanis O,Freundt KJ

更新日期：1983-01-01 00:00:00

abstract：:A toxicity Evaluation of DDT and dieldrin was conducted using Japanese Quail. The effects of feeding DDT (5 and 50 ppm of diet) and dieldrin (0.1 and 1.0 ppm of diet) in this four generation study (parental, F1, F2 and F3) were examined in terms of growth, viability, and/or reproduction of offspring. Ten groups (inclu...

journal_title：Drug and chemical toxicology

authors： Shellenberger TE

更新日期：1978-01-01 00:00:00

abstract：:Various antioxidants play an important role in reducing the reactive oxygen species (ROS) by scavenging them directly or indirectly. Mercury (Hg) is one of the known hazardous genotoxicant, induces the genotoxicity by enhancing the ROS. In the present study, three structurally different bioactive compounds such as mel...

journal_title：Drug and chemical toxicology

authors： Patel TA,Rao MV

更新日期：2015-10-01 00:00:00

abstract：:Mercuric chloride was administered by three routes--subcutaneous, intramuscular and intraperitoneal to adult female Wistar rats. The peroxidative status of the cerebral cortex, cerebellum and the sciatic nerves were studied. Enhanced levels of lipid peroxides indicate progressing cellular injury. All the experimental ...

journal_title：Drug and chemical toxicology

authors： Anuradha B,Rajeswari M,Varalakshmi P

更新日期：1998-02-01 00:00:00

abstract：:Antioxidant activity of Acacia salicina extracts was determined by the ability of each extract to inhibit lipid peroxidation, to protect against DNA strand scission induced by hydroxyl radicals, and to scavenge the free radical, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(*+)). The IC(50) values of t...

journal_title：Drug and chemical toxicology

authors： Bouhlel I,Bhouri W,Limem I,Boubaker J,Nefatti A,Skandrani I,Ben Sghaier M,Kilani S,Ghedira K,Chekir Ghedira L

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Parkinsonism describes Parkinson's disease and other associated degenerative changes in the brain resulting in movement disorders. The motor cortex, extrapyramidal tracts and nigrostriatal tract are brain regions forming part of the motor neural system and are primary targets for drug or chemotoxins induced ...

journal_title：Drug and chemical toxicology

authors： Ogundele OM,Nanakumo ET,Ishola AO,Obende OM,Enye LA,Balogun WG,Cobham AE,Abdulbasit A

更新日期：2015-10-01 00:00:00

abstract：:MG132, as a proteasome inhibitor, has been shown to induce apoptotic cell death through the formation of reactive oxygen species (ROS). In this study, we investigated the effects of MAPK inhibitors on MG132-treated calf pulmonary artery endothelial cells (CPAECs) in relation to cell death, ROS, and glutathione (GSH). ...

journal_title：Drug and chemical toxicology

authors： You BR,Park WH

更新日期：2011-01-01 00:00:00

abstract：:Fertilized hen eggs were topically applied with 2,4-Dichlorophenoxyacetic acid butyl ester (3.1 mg/egg) before starting incubation. During the incubation time 20% of the compound applied on eggs was lost by volatilization. At different incubation times (0, 1, 5, 10 and 15 days) the wash-off technique was applied to fe...

journal_title：Drug and chemical toxicology

authors： Castro de Cantarini SM,Evangelista de Duffard AM,Duffard RO

更新日期：1989-06-01 00:00:00