Abstract:
:Beagle dogs (3 to 6 years old) were treated with 100-150 mg procainamide HC1/kg/day. After 2, 5, and 9 months of treatment, peripheral blood lymphocytes were isolated and stimulated with pokeweed mitogen. The data demonstrated a suppression of mitogenesis only at 2 and 5 months after procainamide treatment. The lymphocytes from dogs treated for 9 months had a normal response to pokeweed mitogen. At no time during this experiment were any significant levels of serum antinuclear antibodies detected nor was any change in the number of cycling lymphocytes apparent in the experimental versus control groups. The resting membrane potential of both control and experimental groups was similar and pokeweed mitogen depolarized the cells from both groups.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Mulhern SA,Daguillard F,Robinson CJ,Balazs Tdoi
10.3109/01480548808998220subject
Has Abstractpub_date
1988-06-01 00:00:00pages
167-79issue
2eissn
0148-0545issn
1525-6014journal_volume
11pub_type
杂志文章abstract::A 1-year chronic toxicity study was conducted in which rhesus monkeys (4/sex/dose) were given daily doses of 0, 3, 10, or 25 mg zatosetron/kg by nasogastric intubation. Clinical signs of toxicity characterized by salivation, diarrhea or soft stools, and/or emesis occurred in animals that received 10 or 25 mg/kg of zat...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549509017858
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548408998411
更新日期:1984-01-01 00:00:00
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540600566832
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549709011076
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2014.900072
更新日期:2015-01-01 00:00:00
abstract::We investigated antigenotoxic and antioxidative effects of newly derivatized compound naringenin-oxime (NG-Ox) compared to its mother compound naringenin (NG) against oxidative damage induced by hydrogen peroxide (HP) in human peripheral blood mononuclear cells (PBMC). Antigenotoxic activity was assessed using alkalin...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2015.1026973
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abstract::This study was designed to test the pulmonary tumor response to intratracheally instilled silica in Strain A mice. Urethane was used as a positive control. Silica treatment was utilized to evaluate the effect of a potent fibrinogen on pulmonary adenoma formation in this unique animal model. Urethane produced an increa...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549009011071
更新日期:1990-01-01 00:00:00
abstract::Nephrotoxicity is a major limitation of adriamycin (ADR) chemotherapy. We hypothesized that administration of standardized aqueous bark extract of Gmelina arborea Roxb. (GA) (Family; Verbenaceae), a traditional therapeutic agent, may reduce the nephrotoxicity caused by ADR in Wistar rats. The dose-dependent nephroprot...
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journal_title:Drug and chemical toxicology
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doi:10.3109/01480547709034424
更新日期:1977-01-01 00:00:00
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548609042827
更新日期:1986-01-01 00:00:00
abstract::The potential genotoxic effect of venlafaxine hydrochloride (venlafaxine), an antidepressant drug-active ingredient, was investigated by using in vitro chromosome aberrations (CAs) and cytokinesis-block micronucleus (CBMN) assays in human peripheral blood lymphocytes (PBLs). Mitotic index (MI) and cytokinesis-block pr...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1486410
更新日期:2020-03-01 00:00:00
abstract::Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaco...
journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
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更新日期:2002-02-01 00:00:00
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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doi:10.3109/01480545.2014.900073
更新日期:2015-01-01 00:00:00
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journal_title:Drug and chemical toxicology
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doi:10.3109/01480549909029733
更新日期:1999-02-01 00:00:00
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journal_title:Drug and chemical toxicology
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更新日期:2004-05-01 00:00:00
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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更新日期:1994-01-01 00:00:00
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
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更新日期:2001-08-01 00:00:00
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548809017882
更新日期:1988-01-01 00:00:00
abstract::The purpose of this research was to evaluate the efficacy of carsil (CAR) either alone or in combination with α-tocopherol (α-TOCO) and/or turmeric (TUMR) against tetrachloromethane (TCM)-induced cardiomyocyte injury in rats. Administration of CAR either alone or in combination with α-TOCO and/or TUMR post-TCM injecti...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
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更新日期:2020-10-15 00:00:00
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1858853
更新日期:2021-01-07 00:00:00
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549209014157
更新日期:1992-01-01 00:00:00
abstract::The present study was aimed to report the toxicity of the chlorpyrifos, an organophosphorus insecticide, with regard to histological and cytological effects through light and transmission electron microscopes in the gills of freshwater fish, Anabas testudineus. The fish were exposed to 0.125 (5% of 96 h LC50), 0.250 (...
journal_title:Drug and chemical toxicology
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abstract::Cyclododecatriene (CDDT, CAS No. 4904-61-4) was administered daily by oral gavage to groups of Crl:CD (SD)IGS BR rats at dose levels of 0 (control), 30, 100, or 300 mg/kg/day. Female rats were dosed for four weeks premating, through mating, gestation, and lactation (a total of 55 to 63 days of treatment). Male rats we...
journal_title:Drug and chemical toxicology
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更新日期:2002-05-01 00:00:00
abstract::Orlistat is an FDA-approved over-the-counter drug to treat obesity through the inhibition of lipase activity. Macrophages, which express high levels of lipoprotein lipase (LPL), are important phagocytes in the innate immune system. Our previous studies indicated that environmentally relevant concentrations of arsenite...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1683571
更新日期:2019-10-31 00:00:00
abstract::Effects of diazinon, at different concentrations and exposure times, were investigated in freshwater fish, Cyprinus carpio, to elucidate the possible mode of action on lipid peroxidation together with the inhibitory effect of diazinon on acetylcholinesterase activity and changes in tissue protein levels. Cholinesteras...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540500408622
更新日期:2006-01-01 00:00:00
abstract::Prolonged exposure to aluminum through occupational hazards or food/water intake has been linked to the occurrence of Alzheimer's disease (AD). This study aimed at investigating the neuroprotective effects of Gallic Acid (GA) against aluminum-chloride induced AD in adult Wistar rats. Twenty eight (28) adult Wistar rat...
journal_title:Drug and chemical toxicology
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更新日期:2020-04-24 00:00:00