Abstract:
:The frequency of dexamethasone-induced cleft palate in mouse fetuses was studied at four fixed times on day 13 of gestation. On day 18, the fetuses were examined for malformations and corticosterone concentration was additionally measured. Evidence of a diurnal rhythm in cleft palate frequency, as well as in corticosterone level was obtained. A reciprocal relationship thereby exists. An increase in the teratogenicity was observed during the dark phase until transition from dark to light. This transition is associated with a decrease in corticosterone.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Sauerbier Idoi
10.3109/01480548609042827subject
Has Abstractpub_date
1986-01-01 00:00:00pages
25-31issue
1eissn
0148-0545issn
1525-6014journal_volume
9pub_type
杂志文章abstract::Polypeptide antibiotics, such as polymyxins and aminoglycosides, are essential for treatment of life-threatening Gram-negative infections. Acute kidney injury (AKI) attributed to treatment with these agents severely limits their clinical application. Because standard biomarkers (serum creatinine [sCRE] and blood urea ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2013.834360
更新日期:2014-04-01 00:00:00
abstract:CONTEXT:Heparin-binding epidermal growth factor like growth factor (HB-EGF) is an emerging therapeutic for the regeneration of the tympanic membrane (TM). OBJECTIVE:Our aim was to determine whether the doses of HB-EGF delivered in a sustained release hydrogel into a middle ear mouse model, would be measurable in the s...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2016.1143482
更新日期:2016-10-01 00:00:00
abstract::Tempol (4-hydroxy tempo), a pleiotropic antioxidant is reported to afford protection against cisplatin (CP)-induced nephrotoxicity. However, molecular mechanisms of action of tempol in improving the renal function in CP-induced nephrotoxicity are not fully understood. We investigated the attenuating effect of tempol a...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1831011
更新日期:2020-10-20 00:00:00
abstract::Eight antineoplastic drugs were evaluated for their ability to induce mutation in the Ames Salmonella/microsome and the TK+/- mouse lymphoma assay. Dose response data were utilized to determine the relative potency of each of these drugs. They were then ranked based on this information. Vincristine, the most potent co...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480547809105021
更新日期:1978-01-01 00:00:00
abstract::The effects of feeding two compounds, dehydroepiandrosterone (DHEA), an adrenal steroid, and clofibrate (CLOF) to rats (which are both hypolipidemic, hepatomegaly inducing and hepatic peroxisome proliferating agents) on the binding of 7,12-dimethylbenz(a)anthracene (DMBA) to hepatic DNA in vivo is compared. Male Sprag...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548908999162
更新日期:1989-09-01 00:00:00
abstract::Many steps are required to convert a normal cell into a cancerous one. The cancer cell must be able to multiply under conditions that a normal cell would not and to invade surrounding tissue and spread throughout the body. Both genetic changes, such as activation of oncogenes or inactivation of tumor suppressor genes,...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章,评审
doi:10.3109/01480549608998231
更新日期:1996-08-01 00:00:00
abstract::Various antioxidants play an important role in reducing the reactive oxygen species (ROS) by scavenging them directly or indirectly. Mercury (Hg) is one of the known hazardous genotoxicant, induces the genotoxicity by enhancing the ROS. In the present study, three structurally different bioactive compounds such as mel...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2014.975354
更新日期:2015-10-01 00:00:00
abstract::This study evaluated the tissue distribution of total radioactivity in male albino, male pigmented, and time-mated female albino rats after oral administration of a single dose of [¹⁴C]-bilastine (20 mg/kg). Although only 1 animal was analyzed at each time point, there were apparent differences in bilastine distributi...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2012.682650
更新日期:2012-06-01 00:00:00
abstract::Heme oxygenase-1 (HO-1) expression, in response to various stimuli, has been generally reported to protect against cellular stress. However, we previously demonstrated simvastatin-induced HO-1-exaggerated nuclear factor kappa beta (NF-κβ) activation and superoxide production on exposure to lipopolysaccharide (LPS). Th...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2010.482587
更新日期:2011-01-01 00:00:00
abstract::The objective of this study was to determine if single/double strand DNA breaks could be induced by monocrotophos (organophosphorus pesticide) in mice in vivo using the comet assay. Mice were dosed orally with 0.046, 0.093, 0.186, 0.373 and 0.746 mg/kg body weight of monocrotophos, and the assay was performed on whole...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-100108472
更新日期:2002-02-01 00:00:00
abstract::Azaperone was evaluated for its mutagenic potential by the Salmonella/microsome test. No mutagenic activity towards six S. typhimurium strains could be evidenced with azaperone at doses up to 2,000 micrograms/plate, either without or with metabolic activation at usual test conditions. Higher concentrations of liver po...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548709042990
更新日期:1987-01-01 00:00:00
abstract::Experimental and clinical data relevant for the evaluation of the carcinogenic potential of the immunosuppressant ciclosporin are reviewed. Ciclosporin binds reversibly to the cytosolic receptor protein ciclophilin. Ciclophilin is likely involved in the blockade of lymphocyte activation-induced gene transcription of v...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章,评审
doi:10.3109/01480549209032293
更新日期:1992-01-01 00:00:00
abstract::The present study was aimed to report the toxicity of the chlorpyrifos, an organophosphorus insecticide, with regard to histological and cytological effects through light and transmission electron microscopes in the gills of freshwater fish, Anabas testudineus. The fish were exposed to 0.125 (5% of 96 h LC50), 0.250 (...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1497052
更新日期:2020-07-01 00:00:00
abstract::S-[3-carbamoylsulfanyl-2-(dimethylamino)propyl] carbamothioate (Cartap) (CAS number: 15263-52-2) is a synthetic insecticide of thiocarbamates group that is extensively used in field of agriculture for controlling of several pests like rice stem borer, leaf folder pests in paddy field and diamond back moth, aphids in c...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1551900
更新日期:2021-03-01 00:00:00
abstract::The quantities of selenium, tar and nicotine present in mainstream (MS) and sidestream (SS) smoke of machine-smoked cigarettes was studied. The cigarettes were prepared from tobacco purposely cultured on fly ash-amended soil so as to increase its selenium concentration. Selenium concentration was found to be the same ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548709042980
更新日期:1987-01-01 00:00:00
abstract::The status of brain antioxidant enzymes and glutathione in methacrylonitrile (MeAN)-intoxicated Wistar rats was correlated with the levels of lipid peroxidation products. Optimum changes were observed 30 min and 60 min after oral administration of MeAN at dosages of 50 mg/kg body weight per day (0.25 LD50) and 100 mg/...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-52536
更新日期:2005-01-01 00:00:00
abstract::The cross-reaction patterns of selected acrylate and methacrylate esters were investigated using the guinea pig maximization test. Methacrylates were less potent sensitizers than acrylates. Cross-sensitization was found between (meth)acrylates with closely related core structures, most extensively between hydroxyethyl...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548409042817
更新日期:1984-01-01 00:00:00
abstract::A large number of cationic amphiphilic drugs (CADs) are known to cause phospholipidosis (PLD) in vivo. In the present study, we have built upon our previous findings to further qualify the use of a fluorescently labeled phospholipid-based cell-culture assay to detect PLD-inducing drugs. In this paper, we demonstrate t...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540802391229
更新日期:2008-01-01 00:00:00
abstract::Cisplatin-induced nephrotoxicity is closely associated with an increase in lipid peroxidation. In several previous reports it was claimed that acetylsalicylic acid (ASA) shows its therapeutic potential as a free radical scavenger. The aim of the study was to investigate effects of ASA on cisplatin induced nephrotoxici...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-120024841
更新日期:2003-11-01 00:00:00
abstract::Ammonium perfluoroocanoate (APFO) was repeatedly administered orally to male Crj:CD(SD)IGS rats for 14 days. Doses of APFO were 0, 0.5, 5, and 50 mg/kg. Significant increases and increasing tendencies in absolute/relative weight of the liver and no change in weight of the spleen were observed in all groups. Although i...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540600653143
更新日期:2006-01-01 00:00:00
abstract::MG132, as a proteasome inhibitor, has been shown to induce apoptotic cell death through the formation of reactive oxygen species (ROS). In this study, we investigated the effects of MG132 and/or MAPK inhibitors on As4.1 juxtaglomerular cells in relation to cell growth, cell death, ROS, and glutathione (GSH) levels. MG...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480540903483458
更新日期:2010-10-01 00:00:00
abstract::p-Octopamine occurs naturally in plants, invertebrates and animals with diverse functions and effects. This review summarizes the chemistry, metabolism, receptor binding characteristics, known physiological functions, and pharmacological and toxicological effects of p-octopamine. Databases used included PubMed and Goo...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章,评审
doi:10.3109/01480545.2014.900069
更新日期:2015-01-01 00:00:00
abstract::The purposes of this study was to determine the toxicological effect of repeated intravenous administration of Activin A/BMP-2 chimera (AB204) in beagle dogs for a long period of four weeks and evaluate two-week recovery. AB204 was administered at doses of 0.08, 0.16, or 0.32 mg/kg/day to three male and three female b...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1572181
更新日期:2019-03-18 00:00:00
abstract::Aluminum (Al)-induced toxicity in fruit fly (Drosophila melanogaster) is one of the established models for studying neurotoxicity and neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, the aim of this study is to determine the effect of alkaloid extrac...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1708377
更新日期:2020-01-03 00:00:00
abstract::Chronic exposure to solar ultraviolet (UV) light induces photoaging in human skin. Our previous results have shown that areca nut procyanidins (ANPs) have antioxidant capacity and possess potential anti-inflammatory effects. Here, we aimed to investigate the effect of ANPs on UVB-induced photoaging. In the present stu...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1696813
更新日期:2019-12-02 00:00:00
abstract::The toxicity of etephon and maleic hydrazide, used as plant growth regulators in agriculture, were reported as low in mammals in previous studies. However, in vitro cytotoxicity studies in mammalian cells are currently missing to understand their toxicity at molecular level. In the current study, the cytotoxicity of t...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2014.884112
更新日期:2014-10-01 00:00:00
abstract::Effects of diazinon, at different concentrations and exposure times, were investigated in freshwater fish, Cyprinus carpio, to elucidate the possible mode of action on lipid peroxidation together with the inhibitory effect of diazinon on acetylcholinesterase activity and changes in tissue protein levels. Cholinesteras...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540500408622
更新日期:2006-01-01 00:00:00
abstract::Orlistat is an FDA-approved over-the-counter drug to treat obesity through the inhibition of lipase activity. Macrophages, which express high levels of lipoprotein lipase (LPL), are important phagocytes in the innate immune system. Our previous studies indicated that environmentally relevant concentrations of arsenite...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1683571
更新日期:2019-10-31 00:00:00
abstract::This study assessed possible adverse immunological effects of trans-1,2-dichloroethylene (DCE) on random-bred CD-1 mice following 14 and 90 days of exposure. A 14-day range-finding study was performed on male mice by gavage at doses 1/10 and 1/100 the LD50 (210 and 21 mg/kg). No alterations in either humoral or cell-m...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548509041066
更新日期:1985-01-01 00:00:00
abstract::Dicyclohexylcarbodiimide (DCC) and diisopropylcarbodiimide (DIC) are two commonly used coupling reagents in protein synthesis resulting in exposure of individuals in chemical and pharmaceutical industries as well as research laboratories involved in protein synthesis and recombinant DNA techniques. The objectives of t...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549809011647
更新日期:1998-05-01 00:00:00