Treatment with p38 inhibitor intensifies the death of MG132-treated As4.1 juxtaglomerular cells via the enhancement of GSH depletion.

abstract：:MG132, as a proteasome inhibitor, has been shown to induce apoptotic cell death through the formation of reactive oxygen species (ROS). In this study, we investigated the effects of MAPK inhibitors on MG132-treated calf pulmonary artery endothelial cells (CPAECs) in relation to cell death, ROS, and glutathione (GSH). ...

journal_title：Drug and chemical toxicology

authors： You BR,Park WH

更新日期：2011-01-01 00:00:00

abstract：:The role of oxidative-stress as a mechanism of hepatotoxicity caused by combination of isoniazid (INH) and Rifampicin (RMP) was investigated in young growing rats. A successful model of hepatotoxicity was produced by giving 50 mg/kg/day each of INH and RMP in two weeks. Liver showed type II hepatocellular changes (mic...

journal_title：Drug and chemical toxicology

authors： Sodhi CP,Rana SV,Mehta SK,Vaiphei K,Attari S,Mehta S

更新日期：1997-08-01 00:00:00

abstract：:It is generally thought that residual unpolymerized (meth)acrylic monomers commonly found in pressure sensitive adhesive tapes for medical use may cause dermal irritation, but a systematic study has never been carried out. Therefore, we assessed the potential dermal irritating effect of residual (meth)acrylic monomers...

journal_title：Drug and chemical toxicology

authors： Tokumura F,Matsui T,Suzuki Y,Sado M,Taniguchi M,Kobayashi I,Kamiyama M,Suda S,Nakamura A,Yamazaki Y,Yamori A,Igarashi R,Kawai J,Oka K

更新日期：2010-01-01 00:00:00

abstract：:The objective of the present study was to evaluate the oxidative stress potential of low-level organophosphate fenthion exposure with the modulatory effect of buthionine sulfoximine in the liver of Cyprinus carpio L. The fish were exposed to 20% of 96-hour LC(50) of fenthion for 24 and 96 hours. Total and oxidized glu...

journal_title：Drug and chemical toxicology

authors： Uner N,Sevgiler Y,Piner P,Durmaz H

更新日期：2008-01-01 00:00:00

abstract：:Cisplatin (CP) is a widely used cytotoxic agent against cancer, and high doses of CP have been known to cause nephrotoxicity and hepatotoxicity. Some reports claim that antioxidants can reduce CP-induced toxicity. This study investigated the hepatoprotective, nephroprotective, and antioxidant activity of Urtica dioica...

journal_title：Drug and chemical toxicology

authors： Özkol H,Musa D,Tuluce Y,Koyuncu I

更新日期：2012-07-01 00:00:00

abstract：:Dicyclohexylcarbodiimide (DCC) and diisopropylcarbodiimide (DIC) are two commonly used coupling reagents in protein synthesis resulting in exposure of individuals in chemical and pharmaceutical industries as well as research laboratories involved in protein synthesis and recombinant DNA techniques. The objectives of t...

journal_title：Drug and chemical toxicology

authors： Hayes BB,Gerber PC,Griffey SS,Meade BJ

更新日期：1998-05-01 00:00:00

abstract：:Neurodegenerative diseases affect millions of people. Major reasons behind the onset and progression of these diseases are still under investigation. Therefore, any approach that would treat/prevent progression is important. In this study, we aimed to investigate the potential protective effects of Psephellus pyrrhobl...

journal_title：Drug and chemical toxicology

authors： Taştan P,Armagan G,Dağcı T,Kıvçak B

更新日期：2019-09-02 00:00:00

abstract：:Three trials involving 184 male Sprague Dawley rats were conducted to identify the biologically active fraction of endophyte-infected tall fescue seed. In trial 1, seed infected (greater than 95%) with the endophytic fungus Acremonium coenophialum and shown to be toxic to cattle, was serially extracted with hexane, et...

journal_title：Drug and chemical toxicology

authors： Jackson JA,Hemken RW,Bush LP,Boling JA,Siegel MR,Zavos PM

更新日期：1987-01-01 00:00:00

abstract：:Aluminum (Al)-induced toxicity in fruit fly (Drosophila melanogaster) is one of the established models for studying neurotoxicity and neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, the aim of this study is to determine the effect of alkaloid extrac...

journal_title：Drug and chemical toxicology

authors： Adedayo BC,Ogunsuyi OB,Akinniyi ST,Oboh G

更新日期：2020-01-03 00:00:00

abstract：:Modafinil is used for the treatment of various sleep disorders; however, its usage among healthy individuals is also increasing. There are a limited number of cardiovascular side effects, including ischemic T-wave changes, dyspnea, hypertension, and tachycardia in the literature. Our research aimed to investigate the ...

journal_title：Drug and chemical toxicology

authors： Canyurt D,Tanriverdi LH,Ozhan O,Cansel M,Parlakpinar H,Vardi N,Cigremis Y,Yildiz A,Karaca Y,Yasar S,Acet A

更新日期：2020-08-11 00:00:00

abstract：:Cisplatin-induced nephrotoxicity is closely associated with an increase in lipid peroxidation. In several previous reports it was claimed that acetylsalicylic acid (ASA) shows its therapeutic potential as a free radical scavenger. The aim of the study was to investigate effects of ASA on cisplatin induced nephrotoxici...

journal_title：Drug and chemical toxicology

authors： Ulubaş B,Cimen MY,Apa DD,Saritaş E,Muşlu N,Cimen OB

更新日期：2003-11-01 00:00:00

abstract：:Experimental and clinical data relevant for the evaluation of the carcinogenic potential of the immunosuppressant ciclosporin are reviewed. Ciclosporin binds reversibly to the cytosolic receptor protein ciclophilin. Ciclophilin is likely involved in the blockade of lymphocyte activation-induced gene transcription of v...

journal_title：Drug and chemical toxicology

authors： Ryffel B,Mihatsch MJ,Fisher GL

更新日期：1992-01-01 00:00:00

abstract：:Adriamycin (ADR) causes morphological and functional alterations in mitochondrial structure in the heart. The study's aim was to determine whether there is a protective effect of selenium (Se) on ADR-induced cardiac damage. Rats were divided into four groups: The first group was injected saline intraperitoneally (i.p....

journal_title：Drug and chemical toxicology

authors： Dursun N,Taşkın E,Yerer Aycan MB,Sahin L

更新日期：2011-04-01 00:00:00

abstract：:Given the increasing prevalence of occupational sensitization to acrylate compounds, n-butyl acrylate (BAC), ethyl acrylate (EAC), and trimethylol propane triacrylate (TMT) were recommended by the National Toxicology Program for hypersensitivity testing in female B6C3F1 mice. The objectives of these studies were to de...

journal_title：Drug and chemical toxicology

authors： Hayes BB,Meade BJ

更新日期：1999-08-01 00:00:00

abstract：:Dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX) pathways of arachidonic acid metabolism prevent cancer development and induce apoptosis. One of the most promising compounds that blocks both of these pathways is licofelone. We questioned whether licofelone affects the survival and/or promotes apoptosis o...

journal_title：Drug and chemical toxicology

authors： Kabadere S,Kus G,Uyar R,Oztopcu-Vatan P

更新日期：2014-01-01 00:00:00

abstract：:Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaco...

journal_title：Drug and chemical toxicology

authors： Ye Q,Liu H,Fang C,Liu Y,Liu X,Liu J,Zhang C,Zhang T,Peng C,Guo L

更新日期：2019-03-21 00:00:00

abstract：:This study was designed to investigate possible interference of Xenobiotics with SUMOylation in eukaryotic cells. To begin with, we docked 71 chemical structures from PubChem with human SUMO1 and UBC9 protein structures using Auto Dock 4.2 and Hex 6.3 and selected five compounds for binding studies in Surface Plasmon ...

journal_title：Drug and chemical toxicology

authors： Yarahalli Jayaram V,Baggavalli S,Reddy D,Sistla S,Malempati R

更新日期：2020-11-01 00:00:00

abstract：:The object of this study was to evaluate the toxicity of norbornene fluoroalcohol (NBFOH), which is used as an intermediate in the production of fluorinated monomers and polymers. NBFOH was evaluated for acute oral, dermal, and inhalation toxicity, dermal sensitization using the Local Lymph Node Assay (LLNA), mutagene...

journal_title：Drug and chemical toxicology

authors： DeLorme MP,Ladics GS,Donner EM,Wagner VO 3rd,Finlay C,Frame SR,Everds NE,Loveless SE

更新日期：2005-01-01 00:00:00

abstract：:In the present study, coffee (CF) was evaluated for its protective effects against genotoxic damage and oxidative stress induced by the chemotherapeutic drug, cyclophosphamide (CPH). The sex-linked recessive lethal (SLRL) test was employed to study the induction of mutations in the larvae as well as in all the success...

journal_title：Drug and chemical toxicology

authors： Nagpal I,Abraham SK

更新日期：2019-09-01 00:00:00

abstract：:The present study enumerates the attenuating effects of curcumin and α-tocopherol against propoxur induced oxidative DNA damage in human peripheral blood mononuclear cells (PBMC). Cultured cells were isolated from peripheral blood of healthy volunteers, and were exposed to varying concentrations of propoxur (0-21 μg/m...

journal_title：Drug and chemical toxicology

authors： Ahmed T,Goel V,Banerjee BD

更新日期：2018-04-01 00:00:00

abstract：:Increasing numbers of older adults use cannabis and cannabis-derived products that can have adverse effects. This study examined management site and level of healthcare services for older adult poison control center cases involving cannabis products. Using the American Association of Poison Control Centers' (PCC) Nati...

journal_title：Drug and chemical toxicology

authors： Choi NG,DiNitto DM,Marti CN,Baker SD

更新日期：2021-01-07 00:00:00

abstract：:This study evaluated the tissue distribution of total radioactivity in male albino, male pigmented, and time-mated female albino rats after oral administration of a single dose of [¹⁴C]-bilastine (20 mg/kg). Although only 1 animal was analyzed at each time point, there were apparent differences in bilastine distributi...

journal_title：Drug and chemical toxicology

authors： Lucero ML,Patterson AB

更新日期：2012-06-01 00:00:00

abstract：:Male Sprague-Dawley rats were administered cadmium chloride 0, 50, 100, 150 and 200 ppm for 30 days. At the end of the treatments, the body weight gains, serum glucose, serum protein, serum glutamic oxalacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were determined. Renal and hepatic key glu...

journal_title：Drug and chemical toxicology

authors： Chapatwala KD,Rajanna B,Desaiah D

更新日期：1980-01-01 00:00:00

abstract：:Concerns that chemical warfare (CW) agents themselves or in combination with other chemicals may cause long-term damage to nerve and muscle are reviewed and discussed. Experiments on mice and hens underway with agent GA and pyridostigmine bromide (PB) and their effects (either separately or together) are presented. ...

journal_title：Drug and chemical toxicology

authors： Wilson BW,Henderson JD,Spencer PS

更新日期：1998-01-01 00:00:00

abstract：:Currently, no standardized and well-validated alternative models exist for screening for progesterone-responsive endocrine disrupting chemicals (EDCs). Because of this, a rapid assay for evaluating progestin/antiprogestin activity using Xenopus oocyte germinal vesicle breakdown (GVBD) as a model was evaluated. Five co...

journal_title：Drug and chemical toxicology

authors： Fort DJ,McLaughlin DW,Rogers RL,Buzzard BO

更新日期：2002-08-01 00:00:00

abstract：:An automatic system was developed to monitor continuously the colonic temperature of laboratory animals during inhalation exposure to toxic chemicals. It includes: an automatic switchbox, a control circuit, a recorder and a digital voltmeter. The system was calibrated for different temperature ranges and used for a ye...

journal_title：Drug and chemical toxicology

authors： Laham S,Schrader K,Symonds G,Curtin W

更新日期：1978-01-01 00:00:00

abstract：:1-((2-methyl-4-[(2-methyl phenyl)azo] phenyl)azo)-2-naphthalenol (C.I. Solvent Red 24) was prepared having a 14C label on the methyl group of the central ring and was administered in suspension intra-tracheally to a male and a female rat. After 96 hours in metabolism cages, the animals were sacrificed and 14C counted ...

journal_title：Drug and chemical toxicology

authors： Parent RA,Dressler I

更新日期：1979-01-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, celecoxib, and etoricoxib are reported to act as chemopreventive agents in experimental colon cancer induced by 1,2-dimethylhydrazine (DMH) as they are known cyclooxygenase (COX) enzyme inhibitors. To determine whether NSAIDs can also effectively modulate ...

journal_title：Drug and chemical toxicology

authors： Kanwar SS,Vaiphei K,Nehru B,Sanyal SN

更新日期：2007-01-01 00:00:00

abstract：:This study assessed possible adverse immunological effects of trans-1,2-dichloroethylene (DCE) on random-bred CD-1 mice following 14 and 90 days of exposure. A 14-day range-finding study was performed on male mice by gavage at doses 1/10 and 1/100 the LD50 (210 and 21 mg/kg). No alterations in either humoral or cell-m...

journal_title：Drug and chemical toxicology

authors： Shopp GM Jr,Sanders VM,White KL Jr,Munson AE

更新日期：1985-01-01 00:00:00

abstract：:Three chemotoxins including dimethylnitrosamine (DMN), carbon tetrachloride (CCl4), and thioacetamide (TAA) are commonly used in hepatofibrotic models. We aimed to draw characteristics of histopathology and pro-fibrogenic cytokines including TGF-β, PDGF and CTGF among three models. Rats were divided into six groups an...

journal_title：Drug and chemical toxicology

authors： Park HJ,Kim HG,Wang JH,Choi MK,Han JM,Lee JS,Son CG

更新日期：2016-01-01 00:00:00