Melatonin modulates copper-induced anxiety-like, depression-like and memory impairments by acting on hippocampal oxidative stress in rat.


:Copper (Cu) is a heavy metal with the ability to induce, at high levels, neurobehavioral alterations, and oxidative stress (OS). On the other hand, melatonin (Mel) is a neurohormone that protects neurons from OS and has a modulatory effect on several behavioral processes. The present experiment was aimed to examine the effect of Mel treatment on Cu-induced anxiety-like, depression-like behaviors, memory impairment, and OS in hippocampus. Herein, adult Wistar rats of both genders received daily Mel (4 mg/kg) thirty minutes before CuCl2 (1 mg/kg), by intraperitoneal injections for 8 weeks. After the administration period, all rats were submitted to the behavioral tests. Thereafter, OS parameters and histology of the hippocampus were evaluated. The results demonstrate that Mel treatment attenuated Cu-induced anxiety-like and depression-like behaviors, and it improved memory deficits Cu-treated rats. Furthermore, Mel attenuated Cu-provoked OS by reducing lipid peroxidation (LPO) and nitric oxide (NO) levels and enhancing superoxide dismutase (SOD) and catalase (CAT) activities in the hippocampus. The histopathological analysis also supported these results. In conclusion, these findings show that Mel treatment exerted neuroprotective effects against Cu-induced neurobehavioral changes which may be related to reduction of hippocampal OS. Besides, the effects of Cu and Mel were gender dependent, being more marked in females compared to male rats.


Drug Chem Toxicol


Lamtai M,Zghari O,Azirar S,Ouakki S,Mesfioui A,El Hessni A,Berkiks I,Marmouzi I,Ouichou A




Has Abstract


2021-01-07 00:00:00








  • Effect of cationic ionophore monensin on the lipid composition and fluidity of rat epididymal spermatozoal membrane.

    abstract::The present study was aimed at exploring the effect of monensin, an antibiotic carboxylic polyether ionophore specific for Na(+), on the structural, chemical, and physiological changes of the epididymal sperm of Wistar rats. Animals received monensin at the dose of 3.5 mg/kg body weight daily orally for 70 days, a tre...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Sharma P,Kanwar SS,Sanyal SN

    更新日期:2013-01-01 00:00:00

  • Gestational lead exposure induces developmental abnormalities and up-regulates apoptosis of fetal cerebellar cells in rats.

    abstract::Lead (Pb), a known environmental toxicant, adversely affects almost all organ systems. In this study, we investigated the effects of maternal lead exposure on fetal rat cerebellum. Female Sprague-Dawley rats were given lead nitrate in drinking water (0, 0.5, and 1%) for two weeks before conception, and during pregnanc...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Mousa AM,Al-Fadhli AS,Rao MS,Kilarkaje N

    更新日期:2015-01-01 00:00:00

  • Neuro-protective effects of nano-formulated hesperetin in a traumatic brain injury model of Danio rerio.

    abstract::Understanding the mechanism behind neuronal regeneration is critical for treating ischemic stroke and traumatic brain injury. The presence of neural stem cells in and around the sub-ventricular zone of human and also in zebrafish is evidenced. In this current study, the neuro-protective potential of nano-formulated he...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Paramita P,Sethu SN,Subhapradha N,Ragavan V,Ilangovan R,Balakrishnan A,Srinivasan N,Murugesan R,Moorthi A

    更新日期:2020-02-12 00:00:00

  • Studies on oral subacute toxicity of cartap in male mice.

    abstract::S-[3-carbamoylsulfanyl-2-(dimethylamino)propyl] carbamothioate (Cartap) (CAS number: 15263-52-2) is a synthetic insecticide of thiocarbamates group that is extensively used in field of agriculture for controlling of several pests like rice stem borer, leaf folder pests in paddy field and diamond back moth, aphids in c...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Sharma LP,Kadve MP,Lingaraju MC,Telang AG

    更新日期:2021-03-01 00:00:00

  • Saffron extracts alleviate cardiomyocytes injury induced by doxorubicin and ischemia-reperfusion in vitro.

    abstract::Doxorubicin (DOX), a highly active chemotherapeutic drug, faces limitations in clinical application due to severe cardiotoxic effects (mainly through increased oxidative stress). Therefore, its effect is exacerbated in subjects with ischemic heart disease. We have recently reported that saffron extract (SAF), a natura...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Chahine N,Nader M,Duca L,Martiny L,Chahine R

    更新日期:2016-01-01 00:00:00

  • Blood acetaldehyde levels in alcohol-dosed rats after treatment with ANIT, ANTU, dithiocarbamate derivatives, or cyanamide.

    abstract::In adult female Wistar rats, pretreated by gavage with two doses - 16 or 256 mumol/kg - of cyanamide, TMTD (tetramethylthiuram disulfide), TMTM (tetramethylthiuram monosulfide), Ziram or Zineb at 90 min or 18 h before administration of 2 g of ethanol/kg i.p., the blood acetaldehyde levels were significantly increased ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: García de Torres G,Römer KG,Torres Alanis O,Freundt KJ

    更新日期:1983-01-01 00:00:00

  • Coordinating activities between NOAA and other agencies.

    abstract::The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and the National Oil and Hazardous Substances Pollution Contingency Plan (NCP) mandate protection of public health, welfare, and the environment at Superfund hazardous waste sites. The NCP requires lead response agenciesto integrate bas...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Fritz AT,Buchman MF

    更新日期:1997-11-01 00:00:00

  • Exposure to pyrethroids induces behavioral impairments, neurofibrillary tangles and tau pathology in Alzheimer's type neurodegeneration in adult Wistar rats.

    abstract::This study investigated the exposure of pyrethroids in the development of Alzheimer's type neurodegeneration by analyzing β- amyloid, tau and Glial Fibrillary Acidic Protein (GFAP) in adult Wistar rats. Forty adult Wistar rats (130-150 g) of both sexes were assigned into five groups (n = 8). Groups A-C were treated wi...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Iteire KA,Sowole AT,Ogunlade B

    更新日期:2020-09-09 00:00:00

  • MG132, a proteasome inhibitor-induced calf pulmonary arterial endothelial cell growth and death, are changed by MAPK inhibitors.

    abstract::MG132, as a proteasome inhibitor, has been shown to induce apoptotic cell death through the formation of reactive oxygen species (ROS). In this study, we investigated the effects of MAPK inhibitors on MG132-treated calf pulmonary artery endothelial cells (CPAECs) in relation to cell death, ROS, and glutathione (GSH). ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: You BR,Park WH

    更新日期:2011-01-01 00:00:00

  • Methyl phenyl selenide causes heme biosynthesis impairment and its toxicity is not modified by dimethyl sulphoxide in vivo.

    abstract::Organoselenium compounds can cause anemia in mice, possibly as a consequence of impairment of the heme biosynthesis pathway. Such compounds can inhibit the sulfhydryl-containing enzyme delta-aminolevulinate dehydratase (delta-ALA-D), which is involved in the heme biosynthetic pathway, leading to a decrease in the synt...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Folmer V,Farina M,Maciel EN,Nogueira CW,Zeni G,Emanuelli T,Rocha JB

    更新日期:2004-11-01 00:00:00

  • Elimination of thioethers following administration of naphthalene and diethylmaleate to the rhesus monkey.

    abstract::As a measure of glutathione (GSH) conjugation, urinary, fecal and biliary excretion of thioethers and hepatic GSH content were measured in rhesus monkeys following administration of single doses of naphthalene and diethylmaleate (DEM). Naphthalene had little or no effect on hepatic GSH content and the excretion of thi...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Rozman K,Summer KH,Rozman T,Greim H

    更新日期:1982-01-01 00:00:00

  • Pharmacologic and toxicologic profile of chymopapain B (Chemolase).

    abstract::The median lethal dose (LD50) of chymopapain B in mice was 82 mg/kg (22,000 units/kg) with 95% confidence limits of 75-90 mg/kg (20, 122-24, 146 units/kg) and in rats 92 (24,683 units/kg) with 95% confidence limits of 83-102 mg/kg (22,268-27, 366 units/kg). The mechanism of toxicity was hemorrhage due to destruction o...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Simmons JW,Upman PJ,Stavinoha WB

    更新日期:1984-01-01 00:00:00

  • Reproductive toxicity and lack of dominant lethal effects of 2,4-dinitrotoluene in the male rat.

    abstract::Adult male Sprague Dawley rats were gavaged with 2,4-dinitrotoluene (2,4-DNT) dissolved in corn oil at 0, 60, 180, or 240 mg/kg/day for five days. A single oral dose (0.5 mg/kg) of triethylenemelamine was used as a positive control. Induction of dominant lethal events was scored on the basis of early fetal deaths. At ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Lane RW,Simon GS,Dougherty RW,Egle JL Jr,Borzelleca JF

    更新日期:1985-01-01 00:00:00

  • Antioxidant responses and DNA damage in primary hepatocytes of Van fish (Alburnus tarichi, Güldenstadt 1814) exposed to nonylphenol or octylphenol.

    abstract::Alkylphenols, a nonionic surface-active agent group, such as nonylphenol (NP) and octylphenol (OP) are important endocrine-disrupting chemicals (EDC). In this study, the dose- and time-dependent effects of NP and OP were investigated in the primary hepatocyte culture of Van Fish. In this study, samples were taken at d...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Çilingir Yeltekin A,Oğuz AR

    更新日期:2018-10-01 00:00:00

  • The toxic effects of a chronic administration of the gut-stimulating principle in Croton penduliflorus hutch. seeds in mice.

    abstract::Albino mice (8-10 wks) weighing between 14 and 25 g were divided into 2 groups and dosed orally once per week with 2 doses (7 mg/kg and 21 mg/kg) of the gut-stimulating principle in Croton penduliflorus seeds (CP crystals) for 12 weeks. Some mice (3-4) from each group were killed at 10 days intervals for the first 6 w...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Asuzu IU,Shetty SN,Anika SM

    更新日期:1989-03-01 00:00:00

  • A straw man proposal for a quantitative definition of the RfD.

    abstract::This paper discusses the merits and disadvantages of a specific proposal for a numerical calculation of the reference dose (RfD) with explicit recognition of both uncertainty and variability. It is suggested that the RfD be the lower (more restrictive) value of: The daily dose rate that is expected (with 95% confidenc...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章,评审


    authors: Hattis D,Baird S,Goble R

    更新日期:2002-11-01 00:00:00

  • An evaluation of the acute in vivo toxicity of benzylidenechroman-4-ones, 1-thiobenzylidenechroman-4-ones and benzylidenetetralones.

    abstract::A series of new compounds were evaluated for acute in vivo toxicity. Their synthesis and antifungal activity have previously been described by us. The naturally occurring class of compounds to which they belong - the benzylidenechroman-4-ones - have been identified as a potential source of new antifungal agents. These...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Al-Nakib TM,Miller NJ,Rashid S,Meegan MJ

    更新日期:1990-01-01 00:00:00

  • Toxic effect of acetamiprid on Rana ridibunda sciatic nerve (electrophysiological and histopathological potential).

    abstract::In this study, the effects of a neonicotinoid insecticide acetamiprid on the sciatic nerve of Rana ridibunda were investigated by using electrophysiological and histological methods. A total of 35 preparations of sciatic nerve isolated from 35 frogs (Nervus ischiadicus) were used in the experiments. Experiments were d...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Çamlıca Y,Bediz SC,Çömelekoğlu Ü,Yilmaz ŞN

    更新日期:2019-05-01 00:00:00

  • Glutathione depletion and resynthesis in laboratory animals.

    abstract::The availability of tissue glutathione (GSH) appears to depend upon a balance between tissue concentrations, the rate of reactive metabolite formation and the re-synthesis of GSH. To test this hypothesis, diethyl maleate (DEM, 5.8 mmol/kg bw) was administered intraperitoneally to male and female mice, hamsters, rats a...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Ecobichon DJ

    更新日期:1984-01-01 00:00:00

  • Modulation of fenthion-induced oxidative effects by BSO in the liver of Cyprinus carpio L.

    abstract::The objective of the present study was to evaluate the oxidative stress potential of low-level organophosphate fenthion exposure with the modulatory effect of buthionine sulfoximine in the liver of Cyprinus carpio L. The fish were exposed to 20% of 96-hour LC(50) of fenthion for 24 and 96 hours. Total and oxidized glu...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Uner N,Sevgiler Y,Piner P,Durmaz H

    更新日期:2008-01-01 00:00:00

  • Butea monosperma (Lam.) Taub. Bark fractions protect against free radicals and induce apoptosis in MCF-7 breast cancer cells via cell-cycle arrest and ROS-mediated pathway.

    abstract::Butea monosperma (Lam.) Taub. is an ethnomedicinal tree of remedial value in the treatment of diabetes, bone fractures, and liver and neurological disorders. However, the information available on DNA-protective and anti-proliferative potential of bark of this tree is scarce. In the present study, the extract/fractions...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Kaur V,Kumar M,Kumar A,Kaur S

    更新日期:2020-07-01 00:00:00

  • Gadolinium-based contrast agents: in vitro paraoxonase 1 inhibition, in silico studies.

    abstract::Medications show their biological effects by interaction with enzymes, which have been known to play an essential role in the pathogenesis of many diseases. Inhibition or induction of drug metabolizing enzymes has an essential place in the drug design for many kinds of diseases including cardiovascular, neurological, ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Beydemir Ş,Türkeş C,Yalçın A

    更新日期:2019-06-09 00:00:00

  • Evaluation of the potential developmental toxicity of cyclododecatriene (CDDT).

    abstract::The potential maternal and developmental toxicity of cyclododecatriene (CDDT) was assessed in rats. Groups of 22 time-mated female Crl:CD (SD) BR rats were exposed by inhalation (whole-body, 6 h/day) to either 0 (control), 10, 25, or 67 ppm CDDT over days 6-20 of gestation (days 6-20 G); the day of copulation plug det...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Munley SM,Kelly DP,Kennedy GL Jr

    更新日期:2003-08-01 00:00:00

  • In vitro metal inhibition of N-methyl-D-aspartate specific glutamate receptor binding in neonatal and adult rat brain.

    abstract::The in vitro effect of methyl mercury (MM) and lead (Pb) on N-methyl-D-aspartate (NMDA)-specific glutamate receptor binding in neonatal (10 days old) and adult rat brain was investigated. The cerebral cortex was isolated from the neonatal and adult male Sprague-Dawley rats and the synaptic plasma membranes were prepar...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Rajanna B,Rajanna S,Hall E,Yallapragada PR

    更新日期:1997-02-01 00:00:00

  • Teratogenic evaluation of p-tert-butylphenol formaldehyde resin (novolak type) in rats following oral exposure.

    abstract::The teratogenicity of p-tert-butylphenol formaldehyde resin, novolak type, (PTBP-FR) was examined in Wistar rats. Pregnant rats were fed diets containing 0, 2.5, 5 or 10% of PTBP-FR ad libitum from day 6 to day 15 of pregnancy. Maternal toxicity, as evidenced by a decreased maternal body weight gain and food consumpti...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Itami T,Ema M,Kawasaki H

    更新日期:1993-01-01 00:00:00

  • Antioxidant and drug detoxification potentials of Hibiscus sabdariffa anthocyanin extract.

    abstract::The antioxidant and drug metabolizing potentials of Hibiscus anthocyanin extract in CCl(4)- induced oxidative damage of rat liver was investigated. Hibiscus anthocyanin extract effectively scavenge α-diphenyl-β-picrylhydrazyl (DPPH) radical, superoxide ion, and hydrogen peroxide. It produced a 92% scavenging effect of...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Ajiboye TO,Salawu NA,Yakubu MT,Oladiji AT,Akanji MA,Okogun JI

    更新日期:2011-04-01 00:00:00

  • Determination of preclinical safety of oil obtained from Pachira aquatica Aublet (Malvaceae) seeds: histopathological, biochemical, hematological, and genetic toxicity studies in rats.

    abstract::Pachira aquatica is a species used for medicinal and food purposes and has numerous phytochemicals that may have systemic toxic effects and damage to genetic material. This study aimed to evaluate acute and short-term oral toxicity, as well as genotoxic and clastogenic effects of oil extracted from P. aquatica (PASO) ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Marcelino JM,Villas Boas GR,Cunha M,Deus Júnior R,Castro LH,Araújo FH,Traesel GK,Dos Santos AC,Souza RI,Paes M,Gubert P,Guterres ZDR,de Lima FF,Silva T,Silva RC,Cardoso CAL,Argandoña EJ,Macorini LF,Oesterreich SA

    更新日期:2020-11-30 00:00:00

  • Effect of celecoxib on Ca(2+) handling and viability in human prostate cancer cells (PC3).

    abstract::Celecoxib has been shown to have an antitumor effect in previous studies, but the mechanisms are unclear. Ca(2+) is a key second messenger in most cells. The effect of celecoxib on cytosolic free Ca(2+) concentrations ([Ca(2+)](i)) in human suspended PC3 prostate cancer cells was explored by using fura-2 as a fluoresc...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Wang JL,Lin KL,Chou CT,Kuo CC,Cheng JS,Hsu SS,Chang HT,Tsai JY,Liao WC,Lu YC,Chen IS,Liu SI,Jan CR

    更新日期:2012-10-01 00:00:00

  • Degree of peroxidative status in neuronal tissues by different routes of inorganic mercury administration.

    abstract::Mercuric chloride was administered by three routes--subcutaneous, intramuscular and intraperitoneal to adult female Wistar rats. The peroxidative status of the cerebral cortex, cerebellum and the sciatic nerves were studied. Enhanced levels of lipid peroxides indicate progressing cellular injury. All the experimental ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Anuradha B,Rajeswari M,Varalakshmi P

    更新日期:1998-02-01 00:00:00

  • Use of staphylococcal enterotoxin A-induced lymphoproliferation and interleukin 2 production as indicators of immunotoxicity.

    abstract::Suppression of mitogen-induced splenocyte lymphoproliferation and interleukin 2 (IL-2) production can be used as indicators of immunotoxicity. Staphylococcal enterotoxin A (SEA) is both a potent mitogen and the most potent in vitro inducer of IL-2 production that has been described. An in vitro system was used to meas...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Reid LL,Hastings KL,Gandolfi AJ,Van Ert M

    更新日期:1994-01-01 00:00:00