Absorption and distribution of C.I. Solvent Red 24 in rats; intra-tracheal administration of 14C labeled dye.

abstract：:Adriamycin (ADR) causes morphological and functional alterations in mitochondrial structure in the heart. The study's aim was to determine whether there is a protective effect of selenium (Se) on ADR-induced cardiac damage. Rats were divided into four groups: The first group was injected saline intraperitoneally (i.p....

journal_title：Drug and chemical toxicology

authors： Dursun N,Taşkın E,Yerer Aycan MB,Sahin L

更新日期：2011-04-01 00:00:00

abstract：:Many steps are required to convert a normal cell into a cancerous one. The cancer cell must be able to multiply under conditions that a normal cell would not and to invade surrounding tissue and spread throughout the body. Both genetic changes, such as activation of oncogenes or inactivation of tumor suppressor genes,...

journal_title：Drug and chemical toxicology

authors： Couch DB

更新日期：1996-08-01 00:00:00

abstract：:Previous work has suggested that endogenous sulfhydryls, such as glutathione (GSH) and cysteine, are involved in the uptake and toxicity of HgCl2. To study this possibility, uptake and toxicity of synthesized Hg(SG)2, Hg(cysteinylglycine)2 [Hg(CYS-GLY)2] and Hg(CYS)2 were investigated in rabbit renal proximal tubule s...

journal_title：Drug and chemical toxicology

authors： Wei H,Qiu L,Divine KK,Ashbaugh MD,McIntyre LC Jr,Fernando Q,Gandolfi AJ

更新日期：1999-05-01 00:00:00

abstract：:Chrysin (CH) is a natural flavone which possesses antioxidant, anti-cancer, and anti-inflammatory properties. The aim of the present study was to investigate the effects of CH on biochemical parameters, histopathological changes, and genotoxicity and hematological indices in diazinon (DZN)-induced toxicity in BALB/c m...

journal_title：Drug and chemical toxicology

authors： Zeinali M,Meybodi NT,Rezaee SA,Rafatpanah H,Hosseinzadeh H

更新日期：2018-07-01 00:00:00

abstract：:The object of this study was to evaluate the toxicity of norbornene fluoroalcohol (NBFOH), which is used as an intermediate in the production of fluorinated monomers and polymers. NBFOH was evaluated for acute oral, dermal, and inhalation toxicity, dermal sensitization using the Local Lymph Node Assay (LLNA), mutagene...

journal_title：Drug and chemical toxicology

authors： DeLorme MP,Ladics GS,Donner EM,Wagner VO 3rd,Finlay C,Frame SR,Everds NE,Loveless SE

更新日期：2005-01-01 00:00:00

abstract：:The teratogenicity of p-tert-butylphenol formaldehyde resin, novolak type, (PTBP-FR) was examined in Wistar rats. Pregnant rats were fed diets containing 0, 2.5, 5 or 10% of PTBP-FR ad libitum from day 6 to day 15 of pregnancy. Maternal toxicity, as evidenced by a decreased maternal body weight gain and food consumpti...

journal_title：Drug and chemical toxicology

authors： Itami T,Ema M,Kawasaki H

更新日期：1993-01-01 00:00:00

abstract：:Concerns that chemical warfare (CW) agents themselves or in combination with other chemicals may cause long-term damage to nerve and muscle are reviewed and discussed. Experiments on mice and hens underway with agent GA and pyridostigmine bromide (PB) and their effects (either separately or together) are presented. ...

journal_title：Drug and chemical toxicology

authors： Wilson BW,Henderson JD,Spencer PS

更新日期：1998-01-01 00:00:00

abstract：:In May 1993, Administrative Browner of the U.S. Environmental Protection Agency (USEPA) announced that an indirect exposure health risk assessment was required for all hazardous waste combustion facilities seeking a Resource Conservation and Recovery Act permit. These types of risk assessments evaluate the health and ...

journal_title：Drug and chemical toxicology

authors： Gaborek BJ

更新日期：2000-02-01 00:00:00

abstract：:Various chemical groups were evaluated for their skin sensitization potential in the guinea pig. In general, amines, acetanilides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further structural-related correlations or predictions sh...

journal_title：Drug and chemical toxicology

authors： Rao KS,Betso JE,Olson KJ

更新日期：1981-01-01 00:00:00

abstract：:Hyperlipidemia causes lipotoxicity which prompts an inflammatory response linked to the development of cardiovascular diseases. Natural compounds have been receiving special attention for its potential to treat diseases, inexpensiveness, and safety. Guarana (Paullinia cupana) has demonstrated notable anti-inflammatory...

journal_title：Drug and chemical toxicology

authors： Ruchel JB,Bernardes VM,Braun JBS,Manzoni AG,Passos DF,Castilhos LG,Abdalla FH,de Oliveira JS,de Andrade CM,Casali EA,da Cruz IBM,Leal DBR

更新日期：2019-06-14 00:00:00

abstract：:The accelerating rotarod was used to assess motor performance decrement in rats after administration of candidate anticonvulsant compounds (acetazolamide, amitriptyline, chlordiazepoxide, diazepam, diazepam-lysine, lorazepam, loprazolam, midazolam, phenobarbital and scopolamine) against nerve agent poisoning. All comp...

journal_title：Drug and chemical toxicology

authors： Capacio BR,Harris LW,Anderson DR,Lennox WJ,Gales V,Dawson JS

更新日期：1992-01-01 00:00:00

abstract：:Cardiotoxicity is commonly associated with cocaine abuse. Previous studies have indicated that cocaine alters myocardial mitochondrial function. This study was undertaken to investigate the effect of cocaine on activity of the mitochondrial electron transport chain in cultures of neonatal rat cardiomyocytes and in iso...

journal_title：Drug and chemical toxicology

authors： Yuan C,Acosta D Jr

更新日期：2000-05-01 00:00:00

abstract：:Three alkyl diamines, which are by-products formed and separated during the production of hexamethylene diamine, have been tested, mostly for their acute toxicity. This paper reviews methodologies used and the results obtained from these three chemicals. All three tested [2-methyl-1,5-pentanediamine (2-MP), 1,3-diamin...

journal_title：Drug and chemical toxicology

authors： Kennedy GL Jr

更新日期：2007-01-01 00:00:00

abstract：:The cytotoxic effect of caffeine on heart cells was evaluated in primary cultures of rat heart muscle (M) and endothelioid (E) cells. The cultures were exposed to 5, 10, or 20 mM caffeine for 6, 12, or 24 hours. As an index of cytotoxicity produced by the treatments, in situ changes in mitochondrial membrane fragility...

journal_title：Drug and chemical toxicology

authors： Acosta D,Anuforo D

更新日期：1977-01-01 00:00:00

abstract：:Orlistat is an FDA-approved over-the-counter drug to treat obesity through the inhibition of lipase activity. Macrophages, which express high levels of lipoprotein lipase (LPL), are important phagocytes in the innate immune system. Our previous studies indicated that environmentally relevant concentrations of arsenite...

journal_title：Drug and chemical toxicology

authors： Lou K,Huang P,Ma H,Wang X,Xu H,Wang W

更新日期：2019-10-31 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental toxin formed as an unintentional by-product of incomplete combustion. Several therapeutic approaches have evolved to combat its toxicity since it elicits immunotoxicity, neurotoxicity, hepatotoxicity, carcinogenicity and lethality. Search for dru...

journal_title：Drug and chemical toxicology

authors： Ilavarasi K,Chermakani P,Arif Nisha S,Sheeja Malar D,Pandima Devi K

更新日期：2015-04-01 00:00:00

abstract：:Medications show their biological effects by interaction with enzymes, which have been known to play an essential role in the pathogenesis of many diseases. Inhibition or induction of drug metabolizing enzymes has an essential place in the drug design for many kinds of diseases including cardiovascular, neurological, ...

journal_title：Drug and chemical toxicology

authors： Beydemir Ş,Türkeş C,Yalçın A

更新日期：2019-06-09 00:00:00

abstract：:Understanding the mechanism behind neuronal regeneration is critical for treating ischemic stroke and traumatic brain injury. The presence of neural stem cells in and around the sub-ventricular zone of human and also in zebrafish is evidenced. In this current study, the neuro-protective potential of nano-formulated he...

journal_title：Drug and chemical toxicology

authors： Paramita P,Sethu SN,Subhapradha N,Ragavan V,Ilangovan R,Balakrishnan A,Srinivasan N,Murugesan R,Moorthi A

更新日期：2020-02-12 00:00:00

abstract：:As part of an occupational hazard evaluation, p-bromobenzyl bromide (p-BBB) was evaluated for genotoxic activity in the Ames microbial mutagenicity assay, the alkaline elution assay for DNA strand breaks in rat hepatocytes and the in vitro chromosome aberration assay in Chinese hamster ovary cells. The compound produc...

journal_title：Drug and chemical toxicology

authors： Sargent EV,Sina JF,Barnum JE,Storer RD,Johnson TE,Galloway SM,Prato MG,Kirsten NN,Naumann BD

更新日期：1999-11-01 00:00:00

abstract：:Antioxidant activity of Acacia salicina extracts was determined by the ability of each extract to inhibit lipid peroxidation, to protect against DNA strand scission induced by hydroxyl radicals, and to scavenge the free radical, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(*+)). The IC(50) values of t...

journal_title：Drug and chemical toxicology

authors： Bouhlel I,Bhouri W,Limem I,Boubaker J,Nefatti A,Skandrani I,Ben Sghaier M,Kilani S,Ghedira K,Chekir Ghedira L

更新日期：2009-01-01 00:00:00

abstract：:In the present study, coffee (CF) was evaluated for its protective effects against genotoxic damage and oxidative stress induced by the chemotherapeutic drug, cyclophosphamide (CPH). The sex-linked recessive lethal (SLRL) test was employed to study the induction of mutations in the larvae as well as in all the success...

journal_title：Drug and chemical toxicology

authors： Nagpal I,Abraham SK

更新日期：2019-09-01 00:00:00

abstract：:Short-term lymphocyte cultures from human peripheral blood samples were incubated with various aliquots of the carbofuran pesticide. After 48 h of initiation and 24 h of exposure to the carbofuran pesticide aliquots, it was seen that carbofuran caused an increase in the frequency of chromosomal aberrations, and the in...

journal_title：Drug and chemical toxicology

authors： Naravaneni R,Jamil K

更新日期：2005-01-01 00:00:00

abstract：:Chemical pretreatment is effective against a 2 LD50 challenge of soman, sarin or VX or a 5 LD50 challenge of tabun. Chemical pretreatment followed by post challenge therapy should be effective against greater levels of agent. Such tests in guinea pigs are reported here; pretreatment regimens (PRGs) consisted of physos...

journal_title：Drug and chemical toxicology

authors： Lennox WJ,Harris LW,Anderson DR,Solana RP,Murrow ML,Wade JV

更新日期：1992-01-01 00:00:00

abstract：:This Visual Basic computer program has been developed for drug dosage conversions using metabolically active mass (MAM) of the animals. The two body weights (one with known dosage and the other, for which the dosage has to be calculated) and the known dosage are entered in the respective input boxes and the appropriat...

journal_title：Drug and chemical toxicology

authors： Khan HA

更新日期：2003-02-01 00:00:00

abstract：:This study evaluated the tissue distribution of total radioactivity in male albino, male pigmented, and time-mated female albino rats after oral administration of a single dose of [¹⁴C]-bilastine (20 mg/kg). Although only 1 animal was analyzed at each time point, there were apparent differences in bilastine distributi...

journal_title：Drug and chemical toxicology

authors： Lucero ML,Patterson AB

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) proteins including collagen that occurs in most types of chronic liver diseases. This study aimed to investigate and compare the therapeutic efficacy of different magnesium (Mg)-containing supplements (formulations A, B, and C) on c...

journal_title：Drug and chemical toxicology

authors： El-Tantawy WH,Sabry D,Abd Al Haleem EN

更新日期：2017-01-01 00:00:00

abstract：:Oxidative stress is produced under diabetic conditions and is likely involved in the progression of pancreatic damage found in diabetes. This study was undertaken to evaluate the protective effect of Aegle marmelos leaf extract, a medicinal plant, on the tissue antioxidant defense system and lipid peroxidative status ...

journal_title：Drug and chemical toxicology

authors： Narendhirakannan RT,Subramanian S

更新日期：2010-04-01 00:00:00

abstract：:Alkylphenols, a nonionic surface-active agent group, such as nonylphenol (NP) and octylphenol (OP) are important endocrine-disrupting chemicals (EDC). In this study, the dose- and time-dependent effects of NP and OP were investigated in the primary hepatocyte culture of Van Fish. In this study, samples were taken at d...

journal_title：Drug and chemical toxicology

authors： Çilingir Yeltekin A,Oğuz AR

更新日期：2018-10-01 00:00:00

abstract：:p-Octopamine occurs naturally in plants, invertebrates and animals with diverse functions and effects. This review summarizes the chemistry, metabolism, receptor binding characteristics, known physiological functions, and pharmacological and toxicological effects of p-octopamine. Databases used included PubMed and Goo...

journal_title：Drug and chemical toxicology

authors： Stohs SJ

更新日期：2015-01-01 00:00:00

abstract：:Hepatic cysteamine and non-protein sulfhydryl (NPSH) levels were determined in galactosamine (GAL)-poisoned rats following hepatoprotective cystamine or cysteamine treatments to determine whether alterations of hepatic NPSH status could contribute to their observed protective actions. D(+)-Galactosamine HC1 (400 mg/kg...

journal_title：Drug and chemical toxicology

authors： MacDonald JR,Gandolfi AJ,Sipes IG

更新日期：1985-01-01 00:00:00