Protective effects of chrysin on sub-acute diazinon-induced biochemical, hematological, histopathological alterations, and genotoxicity indices in male BALB/c mice.

abstract：:Copper (Cu) is a heavy metal with the ability to induce, at high levels, neurobehavioral alterations, and oxidative stress (OS). On the other hand, melatonin (Mel) is a neurohormone that protects neurons from OS and has a modulatory effect on several behavioral processes. The present experiment was aimed to examine th...

journal_title：Drug and chemical toxicology

authors： Lamtai M,Zghari O,Azirar S,Ouakki S,Mesfioui A,El Hessni A,Berkiks I,Marmouzi I,Ouichou A

更新日期：2021-01-07 00:00:00

abstract：:Gold nanorods (GNRs) are used for their wide variety of applications in various industries. There is a little availability of data related to toxicity and ecological implications of these GNRs. The study evaluated the oxidative stress induction following intra-tracheal instillation of 1 and 5 mg/kg b.w. doses of 10 an...

journal_title：Drug and chemical toxicology

authors： Lingabathula H,Yellu N

更新日期：2018-04-01 00:00:00

abstract：:Dicyclohexylcarbodiimide (DCC) and diisopropylcarbodiimide (DIC) are two commonly used coupling reagents in protein synthesis resulting in exposure of individuals in chemical and pharmaceutical industries as well as research laboratories involved in protein synthesis and recombinant DNA techniques. The objectives of t...

journal_title：Drug and chemical toxicology

authors： Hayes BB,Gerber PC,Griffey SS,Meade BJ

更新日期：1998-05-01 00:00:00

abstract：:This study was conducted to evaluate the potential reproductive toxicity of epichlorohydrin in a one-generation reproduction toxicity study in compliance with OECD Test Guideline 415. Twenty-four male and female rats per group were given epichlorohydrin by gavage at 0, 3.3, 10, and 30 mg/kg/day. Males were dosed for 1...

journal_title：Drug and chemical toxicology

authors： Shin IS,Park NH,Lee JC,Kim KH,Moon C,Kim SH,Shin DH,Park SC,Kim HY,Kim JC

更新日期：2010-07-01 00:00:00

abstract：:Cadmium (Cd) is a ubiquitous non-essential environmental and industrial toxicant that affects various organs in humans and experimental animals. Robust evidence confirms the contribution of oxidative stress to the pathogenesis of Cd-induced hepatic damage. Potent polyphenols found in virgin coconut oil (VCO) are free ...

journal_title：Drug and chemical toxicology

authors： Famurewa AC,Ugwu-Ejezie CS,Iyare EE,Folawiyo AM,Maduagwuna EK,Ejezie FE

更新日期：2019-04-25 00:00:00

abstract：:It is generally thought that residual unpolymerized (meth)acrylic monomers commonly found in pressure sensitive adhesive tapes for medical use may cause dermal irritation, but a systematic study has never been carried out. Therefore, we assessed the potential dermal irritating effect of residual (meth)acrylic monomers...

journal_title：Drug and chemical toxicology

authors： Tokumura F,Matsui T,Suzuki Y,Sado M,Taniguchi M,Kobayashi I,Kamiyama M,Suda S,Nakamura A,Yamazaki Y,Yamori A,Igarashi R,Kawai J,Oka K

更新日期：2010-01-01 00:00:00

abstract：:Dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX) pathways of arachidonic acid metabolism prevent cancer development and induce apoptosis. One of the most promising compounds that blocks both of these pathways is licofelone. We questioned whether licofelone affects the survival and/or promotes apoptosis o...

journal_title：Drug and chemical toxicology

authors： Kabadere S,Kus G,Uyar R,Oztopcu-Vatan P

更新日期：2014-01-01 00:00:00

abstract：:The antioxidant and drug metabolizing potentials of Hibiscus anthocyanin extract in CCl(4)- induced oxidative damage of rat liver was investigated. Hibiscus anthocyanin extract effectively scavenge α-diphenyl-β-picrylhydrazyl (DPPH) radical, superoxide ion, and hydrogen peroxide. It produced a 92% scavenging effect of...

journal_title：Drug and chemical toxicology

authors： Ajiboye TO,Salawu NA,Yakubu MT,Oladiji AT,Akanji MA,Okogun JI

更新日期：2011-04-01 00:00:00

abstract：:During a preclinical safety evaluation study, an indication of ocular toxicity was noted in beagle dogs receiving orally (gelatin capsules) once a day, 7 days a week for, respectively, 7 and 91 days, 10 mg/kg/day of Lortalamine, a new non-tricyclic anti-depressant compound. Lortalamine treated dogs showed, progressive...

journal_title：Drug and chemical toxicology

authors： Mally C,Thiebault JJ

更新日期：1990-01-01 00:00:00

abstract：:Hepatic cysteamine and non-protein sulfhydryl (NPSH) levels were determined in galactosamine (GAL)-poisoned rats following hepatoprotective cystamine or cysteamine treatments to determine whether alterations of hepatic NPSH status could contribute to their observed protective actions. D(+)-Galactosamine HC1 (400 mg/kg...

journal_title：Drug and chemical toxicology

authors： MacDonald JR,Gandolfi AJ,Sipes IG

更新日期：1985-01-01 00:00:00

abstract：:The cross-reaction patterns of selected acrylate and methacrylate esters were investigated using the guinea pig maximization test. Methacrylates were less potent sensitizers than acrylates. Cross-sensitization was found between (meth)acrylates with closely related core structures, most extensively between hydroxyethyl...

journal_title：Drug and chemical toxicology

authors： Clemmensen S

更新日期：1984-01-01 00:00:00

abstract：:In this study, the hepatoprotective activity of methanol bark extract of Alangium salviifolium (BEA) was evaluated for biochemical and histological parameters in swiss albino mice with CCl4-induced hepatotoxicity. The hepatomodulatory effect of two doses of BEA (20 and 50 mg/kg bw for 15 days by oral gavage) was asses...

journal_title：Drug and chemical toxicology

authors： Dhruve P,Nauman M,Kale RK,Singh RP

更新日期：2020-03-06 00:00:00

abstract：:A series of new compounds were evaluated for acute in vivo toxicity. Their synthesis and antifungal activity have previously been described by us. The naturally occurring class of compounds to which they belong - the benzylidenechroman-4-ones - have been identified as a potential source of new antifungal agents. These...

journal_title：Drug and chemical toxicology

authors： Al-Nakib TM,Miller NJ,Rashid S,Meegan MJ

更新日期：1990-01-01 00:00:00

abstract：:The toxicity of chloropicrin (CP) was assessed following its administration to rats via oral gavage for either 10 or 90 consecutive days at dose levels of 10, 20, 40, and 80 mg/kg and 2, 8 and 32 mg/kg, respectively. Control rats received corn oil at a dose of 1.0 ml/kg. Toxicological observations included organ and b...

journal_title：Drug and chemical toxicology

authors： Condie LW,Daniel FB,Olson GR,Robinson M

更新日期：1994-01-01 00:00:00

abstract：:Fertilized hen eggs were topically applied with 2,4-Dichlorophenoxyacetic acid butyl ester (3.1 mg/egg) before starting incubation. During the incubation time 20% of the compound applied on eggs was lost by volatilization. At different incubation times (0, 1, 5, 10 and 15 days) the wash-off technique was applied to fe...

journal_title：Drug and chemical toxicology

authors： Castro de Cantarini SM,Evangelista de Duffard AM,Duffard RO

更新日期：1989-06-01 00:00:00

abstract：:As part of an occupational hazard evaluation, p-bromobenzyl bromide (p-BBB) was evaluated for genotoxic activity in the Ames microbial mutagenicity assay, the alkaline elution assay for DNA strand breaks in rat hepatocytes and the in vitro chromosome aberration assay in Chinese hamster ovary cells. The compound produc...

journal_title：Drug and chemical toxicology

authors： Sargent EV,Sina JF,Barnum JE,Storer RD,Johnson TE,Galloway SM,Prato MG,Kirsten NN,Naumann BD

更新日期：1999-11-01 00:00:00

abstract：:In our previous reports, aspirin, an antipyretic analgesic, suppressed the genotoxicity of mitomycin C (MMC) in a somatic mutation and recombination test (SMART) in Drosophila melanogaster. In order to reveal the mechanism of the anti-genotoxicity of aspirin, we evaluated the suppressing ability of each aspirin metabo...

journal_title：Drug and chemical toxicology

authors： Niikawa M,Nakamura T,Nagase H

更新日期：2006-01-01 00:00:00

abstract：:Pefloxacin is a second-generation fluoroquinolone antibiotic. Besides its advantageous characteristics, side effects including the hypofunction of salivary glands, decreased saliva production, and peripheral neuropathy were observed during the administration of pefloxacin. The aim of this study was to investigate the ...

journal_title：Drug and chemical toxicology

authors： Skopkó BE,Deák Á,Matesz C,Kelentey B,Bácskai T

更新日期：2020-09-01 00:00:00

abstract：:A 1-year chronic toxicity study was conducted in which rhesus monkeys (4/sex/dose) were given daily doses of 0, 3, 10, or 25 mg zatosetron/kg by nasogastric intubation. Clinical signs of toxicity characterized by salivation, diarrhea or soft stools, and/or emesis occurred in animals that received 10 or 25 mg/kg of zat...

journal_title：Drug and chemical toxicology

authors： Bendele A,Means J,Shoufler J,Schmalz C,Hanasono G,Symanowski J,Adams E

更新日期：1995-02-01 00:00:00

abstract：:Three alkyl diamines, which are by-products formed and separated during the production of hexamethylene diamine, have been tested, mostly for their acute toxicity. This paper reviews methodologies used and the results obtained from these three chemicals. All three tested [2-methyl-1,5-pentanediamine (2-MP), 1,3-diamin...

journal_title：Drug and chemical toxicology

authors： Kennedy GL Jr

更新日期：2007-01-01 00:00:00

abstract：:The effect of chlormethiazole (CMZ) at single and multiple doses on the toxicokinetics of diethylnitrosamine (DEN) was investigated in normal rats and those with DEN-induced liver fibrosis. Twelve rats were treated with DEN (50 mg/kg) alone and in combination with a single dose of CMZ (10, 50, or 100 mg/kg) by intrape...

journal_title：Drug and chemical toxicology

authors： Wang G,Xiao K,Gao J,Jiang S,Wang S,Weng S,Xu C,Wang T,Qiao HL

更新日期：2019-11-01 00:00:00

abstract：:The venoms of wasps are a complex mixture of biologically active compounds, such as low molecular mass compounds, peptides, and proteins. The aim of the study was to evaluate the action of wasp venoms, Polybia occidentalis and Polybia fastidiosa, on the DNA of human leukocytes and on the cell cycle and genetic materia...

journal_title：Drug and chemical toxicology

authors： José Palmieri M,Ribeiro Barroso A,Fonseca Andrade-Vieira L,Monteiro MC,Martins Soares A,Souza Cesar PH,Aparecida Braga M,Cardoso Trento MV,Marcussi S,Chamma Davide L

更新日期：2019-07-01 00:00:00

abstract：:The intoxication of insecticides such as bifenthrin and diazinon has been reported to generate free radicals, and thereby alter the antioxidant defense system in erythrocytes. The present study is aimed to investigate the protective effects of acetone (DA) and methanolic (DM) extracts of lichen Dirinaria consimilis ag...

journal_title：Drug and chemical toxicology

authors： Tatipamula VB,Kukavica B

更新日期：2020-05-12 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, celecoxib, and etoricoxib are reported to act as chemopreventive agents in experimental colon cancer induced by 1,2-dimethylhydrazine (DMH) as they are known cyclooxygenase (COX) enzyme inhibitors. To determine whether NSAIDs can also effectively modulate ...

journal_title：Drug and chemical toxicology

authors： Kanwar SS,Vaiphei K,Nehru B,Sanyal SN

更新日期：2007-01-01 00:00:00

abstract：:1-((2-methyl-4-[(2-methyl phenyl)azo] phenyl)azo)-2-naphthalenol (C.I. Solvent Red 24) was prepared having a 14C label on the methyl group of the central ring and was administered in suspension intra-tracheally to a male and a female rat. After 96 hours in metabolism cages, the animals were sacrificed and 14C counted ...

journal_title：Drug and chemical toxicology

authors： Parent RA,Dressler I

更新日期：1979-01-01 00:00:00

abstract：:This study evaluated the tissue distribution of total radioactivity in male albino, male pigmented, and time-mated female albino rats after oral administration of a single dose of [¹⁴C]-bilastine (20 mg/kg). Although only 1 animal was analyzed at each time point, there were apparent differences in bilastine distributi...

journal_title：Drug and chemical toxicology

authors： Lucero ML,Patterson AB

更新日期：2012-06-01 00:00:00

abstract：:The immunomodulatory effects of two plant regulators, cycloheximide and maleic hydrazide, were investigated by injecting the compounds twice weekly for 4 weeks in female Swiss Webster white mice. The animals were antigenically challenged with sheep red blood cells on day 24 of the study. Although humoral immunity was ...

journal_title：Drug and chemical toxicology

authors： Olson LJ,Hinsdill RD,Weltman DJ

更新日期：1983-01-01 00:00:00

abstract：:The relationship between lead concentration in the dry film of lead based paints applied to steel bulkheads aboard ship, the lead concentration found in the air when the paint is removed by mechanical means, and blood lead concentrations of workers involved in lead based paint removal has not been well characterized. ...

journal_title：Drug and chemical toxicology

authors： Alexander WK,Carpenter RL,Kimmel EC

更新日期：1999-02-01 00:00:00

abstract：:Acute and repeated oral and dermal rat toxicology studies of standard designs were conducted on four methyl ethyl ketoxime (MEKO) silanes and four methyl isobutyl ketoxime (MIBKO) silanes. Each compound contained either MEKO or MIBKO groups (but not both) and either a single methyl, vinyl, or phenyl group (trifunction...

journal_title：Drug and chemical toxicology

authors： Derelanko MJ,Rusch GM

更新日期：2008-01-01 00:00:00

abstract：:Hexachloroethane (HCE) was fed to Fischer 344 rats at approximate doses of 0, 1, 15 or 62 mg/kg/day for 16 weeks. Selected tissues were assayed at termination for HCE content. Histopathological examination identified the kidney as the primary target organ with male rats more sensitive than female rats. The kidney conc...

journal_title：Drug and chemical toxicology

authors： Gorzinski SJ,Nolan RJ,McCollister SB,Kociba RJ,Mattsson JL

更新日期：1985-01-01 00:00:00