Effect of endosulfan and bisphenol A on the expression of SUMO and UBC9.

abstract：:The effects of feeding two compounds, dehydroepiandrosterone (DHEA), an adrenal steroid, and clofibrate (CLOF) to rats (which are both hypolipidemic, hepatomegaly inducing and hepatic peroxisome proliferating agents) on the binding of 7,12-dimethylbenz(a)anthracene (DMBA) to hepatic DNA in vivo is compared. Male Sprag...

journal_title：Drug and chemical toxicology

authors： Prasanna HR,Hart RW,Magee PN

更新日期：1989-09-01 00:00:00

abstract：:In this study, the effects of a neonicotinoid insecticide acetamiprid on the sciatic nerve of Rana ridibunda were investigated by using electrophysiological and histological methods. A total of 35 preparations of sciatic nerve isolated from 35 frogs (Nervus ischiadicus) were used in the experiments. Experiments were d...

journal_title：Drug and chemical toxicology

authors： Çamlıca Y,Bediz SC,Çömelekoğlu Ü,Yilmaz ŞN

更新日期：2019-05-01 00:00:00

abstract：:In the subchronic study acrylic acid was incorporated in the drinking water of Fischer 344 rats (15 per group) for three months at dosage levels of 0.75, 0.25, 0.083 or 0 g/kg/day. No deaths occurred during the study but several treatment-related effects were observed. At 0.75 g/kg/day dosage level, body weight gain w...

journal_title：Drug and chemical toxicology

authors： DePass LR,Woodside MD,Garman RH,Weil CS

更新日期：1983-01-01 00:00:00

abstract：:Aluminum (Al)-induced toxicity in fruit fly (Drosophila melanogaster) is one of the established models for studying neurotoxicity and neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, the aim of this study is to determine the effect of alkaloid extrac...

journal_title：Drug and chemical toxicology

authors： Adedayo BC,Ogunsuyi OB,Akinniyi ST,Oboh G

更新日期：2020-01-03 00:00:00

abstract：:The disposition of N-[14C-vinyl]-2-pyrrolidinone was studied in male Sprague-Dawley rats following a single iv injection. Plasma levels of the intact compound dropped rapidly within the first 6 hours after dosing with a half life of 1.90 hours. Urinary excretion by 12 hours represented 74.9% of a 5 microCi dose while ...

journal_title：Drug and chemical toxicology

authors： McClanahan JS,Lin YC,Digenis GA

更新日期：1984-01-01 00:00:00

abstract：:Many pharmaceuticals are administered to children and adults as sprays provided in nebulizers or metered-dose inhalers. Stress associated with possible eye irritation and injury attributable to exposure to vapors and particulates during the required safety testing procedures of such medicines is a potential confoundin...

journal_title：Drug and chemical toxicology

authors： Rothenberg SJ,Martin MM,Sherer KI,Parker RM,Dearlove GE,Christian MS

更新日期：1998-08-01 00:00:00

abstract：:Three chemotoxins including dimethylnitrosamine (DMN), carbon tetrachloride (CCl4), and thioacetamide (TAA) are commonly used in hepatofibrotic models. We aimed to draw characteristics of histopathology and pro-fibrogenic cytokines including TGF-β, PDGF and CTGF among three models. Rats were divided into six groups an...

journal_title：Drug and chemical toxicology

authors： Park HJ,Kim HG,Wang JH,Choi MK,Han JM,Lee JS,Son CG

更新日期：2016-01-01 00:00:00

abstract：:Adriamycin (ADR) causes morphological and functional alterations in mitochondrial structure in the heart. The study's aim was to determine whether there is a protective effect of selenium (Se) on ADR-induced cardiac damage. Rats were divided into four groups: The first group was injected saline intraperitoneally (i.p....

journal_title：Drug and chemical toxicology

authors： Dursun N,Taşkın E,Yerer Aycan MB,Sahin L

更新日期：2011-04-01 00:00:00

abstract：:Rotenone, an environmental toxin, triggers Parkinson's disease (PD)-like pathology through microglia-mediated neuronal death. The effects and molecular mechanisms of flavonoid luteolin against rotenone-induced toxicity was assessed in microglial BV2 cells. Cells were pretreated with luteolin (1-50 µM) for 12 h and the...

journal_title：Drug and chemical toxicology

authors： Elmazoglu Z,Yar Saglam AS,Sonmez C,Karasu C

更新日期：2020-01-01 00:00:00

abstract：:The objective of this study was to determine if single/double strand DNA breaks could be induced by monocrotophos (organophosphorus pesticide) in mice in vivo using the comet assay. Mice were dosed orally with 0.046, 0.093, 0.186, 0.373 and 0.746 mg/kg body weight of monocrotophos, and the assay was performed on whole...

journal_title：Drug and chemical toxicology

authors： Mahboob M,Rahman MF,Danadevi K,Banu BS,Grover P

更新日期：2002-02-01 00:00:00

abstract：:Transient global ischemia continues to be an important clinical problem with limited treatment options. The present study aimed to investigate the possible protective effects of celecoxib [a selective cyclooxygenase (COX-2) inhibitor] and N-omega-nitro-L-arginine methyl ester (L-NAME) [a nonselective nitric oxide synt...

journal_title：Drug and chemical toxicology

authors： Abd El-Aal SA,El-Sawalhi MM,Seif-El-Nasr M,Kenawy SA

更新日期：2013-10-01 00:00:00

abstract：:This study investigated the effect of Thyme (Thymus vulgaris) leaf aqueous extract (TE) on purine and acetylcholine hydrolyzing enzyme activities and antioxidant status in the brain of 5-fluorouracil (5-FLU) administered rats. Sixty adult Wistar rats (210-225 g) were divided into Ten groups (n = 6). Group 1: received ...

journal_title：Drug and chemical toxicology

authors： Adefegha SA,Oyeleye SI,Akintemi A,Okeke BM,Oboh G

更新日期：2020-01-01 00:00:00

abstract：:The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and the National Oil and Hazardous Substances Pollution Contingency Plan (NCP) mandate protection of public health, welfare, and the environment at Superfund hazardous waste sites. The NCP requires lead response agenciesto integrate bas...

journal_title：Drug and chemical toxicology

authors： Fritz AT,Buchman MF

更新日期：1997-11-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) expression, in response to various stimuli, has been generally reported to protect against cellular stress. However, we previously demonstrated simvastatin-induced HO-1-exaggerated nuclear factor kappa beta (NF-κβ) activation and superoxide production on exposure to lipopolysaccharide (LPS). Th...

journal_title：Drug and chemical toxicology

authors： Hsieh CH,Jeng JC,Hsieh MW,Chen YC,Lu TH,Rau CS,Jeng SF

更新日期：2011-01-01 00:00:00

abstract：:Suppression of mitogen-induced splenocyte lymphoproliferation and interleukin 2 (IL-2) production can be used as indicators of immunotoxicity. Staphylococcal enterotoxin A (SEA) is both a potent mitogen and the most potent in vitro inducer of IL-2 production that has been described. An in vitro system was used to meas...

journal_title：Drug and chemical toxicology

authors： Reid LL,Hastings KL,Gandolfi AJ,Van Ert M

更新日期：1994-01-01 00:00:00

abstract：:The object of this study was to evaluate the toxicity of norbornene fluoroalcohol (NBFOH), which is used as an intermediate in the production of fluorinated monomers and polymers. NBFOH was evaluated for acute oral, dermal, and inhalation toxicity, dermal sensitization using the Local Lymph Node Assay (LLNA), mutagene...

journal_title：Drug and chemical toxicology

authors： DeLorme MP,Ladics GS,Donner EM,Wagner VO 3rd,Finlay C,Frame SR,Everds NE,Loveless SE

更新日期：2005-01-01 00:00:00

abstract：:Fertilized hen eggs were topically applied with 2,4-Dichlorophenoxyacetic acid butyl ester (3.1 mg/egg) before starting incubation. During the incubation time 20% of the compound applied on eggs was lost by volatilization. At different incubation times (0, 1, 5, 10 and 15 days) the wash-off technique was applied to fe...

journal_title：Drug and chemical toxicology

authors： Castro de Cantarini SM,Evangelista de Duffard AM,Duffard RO

更新日期：1989-06-01 00:00:00

abstract：:Celecoxib has been shown to have an antitumor effect in previous studies, but the mechanisms are unclear. Ca(2+) is a key second messenger in most cells. The effect of celecoxib on cytosolic free Ca(2+) concentrations ([Ca(2+)](i)) in human suspended PC3 prostate cancer cells was explored by using fura-2 as a fluoresc...

journal_title：Drug and chemical toxicology

authors： Wang JL,Lin KL,Chou CT,Kuo CC,Cheng JS,Hsu SS,Chang HT,Tsai JY,Liao WC,Lu YC,Chen IS,Liu SI,Jan CR

更新日期：2012-10-01 00:00:00

abstract：:Medications show their biological effects by interaction with enzymes, which have been known to play an essential role in the pathogenesis of many diseases. Inhibition or induction of drug metabolizing enzymes has an essential place in the drug design for many kinds of diseases including cardiovascular, neurological, ...

journal_title：Drug and chemical toxicology

authors： Beydemir Ş,Türkeş C,Yalçın A

更新日期：2019-06-09 00:00:00

abstract：:The 24-h incorporation of 59Fe into circulating red blood cells, bone marrow, urine, liver, spleen, and skeletal muscle was measured in splenectomized and sham-splenectomized rats which had received a daily, oral dose of gossypol acetic acid (20 mg GAA/kg body wt) for 91 days. A significant decrease in total body weig...

journal_title：Drug and chemical toxicology

authors： Tone JN,Jensen DR

更新日期：1985-01-01 00:00:00

abstract：:Gold nanorods (GNRs) are used for their wide variety of applications in various industries. There is a little availability of data related to toxicity and ecological implications of these GNRs. The study evaluated the oxidative stress induction following intra-tracheal instillation of 1 and 5 mg/kg b.w. doses of 10 an...

journal_title：Drug and chemical toxicology

authors： Lingabathula H,Yellu N

更新日期：2018-04-01 00:00:00

abstract：CONTEXT:Withania somnifera (L) Dunal (Solanaceae) is an important traditional herbal medicine used for thousands of years and is considered as the Indian ginseng. Reports on the effect of Withania somnifera root (WSR) extract on the developing foetus of pregnant rats including mortality, structural abnormalities, chang...

journal_title：Drug and chemical toxicology

authors： Prabu PC,Panchapakesan S

更新日期：2015-01-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental toxin formed as an unintentional by-product of incomplete combustion. Several therapeutic approaches have evolved to combat its toxicity since it elicits immunotoxicity, neurotoxicity, hepatotoxicity, carcinogenicity and lethality. Search for dru...

journal_title：Drug and chemical toxicology

authors： Ilavarasi K,Chermakani P,Arif Nisha S,Sheeja Malar D,Pandima Devi K

更新日期：2015-04-01 00:00:00

abstract：:Cyclododecatriene (CDDT, CAS No. 4904-61-4) was administered daily by oral gavage to groups of Crl:CD (SD)IGS BR rats at dose levels of 0 (control), 30, 100, or 300 mg/kg/day. Female rats were dosed for four weeks premating, through mating, gestation, and lactation (a total of 55 to 63 days of treatment). Male rats we...

journal_title：Drug and chemical toxicology

authors： Malley LA,Everds NE,Makovec GT,Kennedy GL Jr

更新日期：2002-05-01 00:00:00

abstract：:Various chemical groups were evaluated for their skin sensitization potential in the guinea pig. In general, amines, acetanilides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further structural-related correlations or predictions sh...

journal_title：Drug and chemical toxicology

authors： Rao KS,Betso JE,Olson KJ

更新日期：1981-01-01 00:00:00

abstract：:Male Sprague-Dawley rats were administered cadmium chloride 0, 50, 100, 150 and 200 ppm for 30 days. At the end of the treatments, the body weight gains, serum glucose, serum protein, serum glutamic oxalacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were determined. Renal and hepatic key glu...

journal_title：Drug and chemical toxicology

authors： Chapatwala KD,Rajanna B,Desaiah D

更新日期：1980-01-01 00:00:00

abstract：:Lavender and immortelle essential oils (EOs) are widely used to treat a spectrum of human conditions. The aim of this study was to investigate cyto/genotoxic effects of lavender and immortelle EOs using plant cells (Allium cepa) and human lymphocytes, as well as their antimicrobial potential using nine strains of bact...

journal_title：Drug and chemical toxicology

authors： Mesic A,Mahmutović-Dizdarević I,Tahirović E,Durmišević I,Eminovic I,Jerković-Mujkić A,Bešta-Gajević R

更新日期：2021-03-01 00:00:00

abstract：:Three trials involving 184 male Sprague Dawley rats were conducted to identify the biologically active fraction of endophyte-infected tall fescue seed. In trial 1, seed infected (greater than 95%) with the endophytic fungus Acremonium coenophialum and shown to be toxic to cattle, was serially extracted with hexane, et...

journal_title：Drug and chemical toxicology

authors： Jackson JA,Hemken RW,Bush LP,Boling JA,Siegel MR,Zavos PM

更新日期：1987-01-01 00:00:00

abstract：:Cis-1,2-dichloroethylene was administered daily by corn oil gavage to male and female Sprague-Dawley rats at the following dose levels: 1.0, 3.0, 10.0 and 22.0 mmol/kg/day for 14 days. Doses gavaged during the 90-day subchronic study were 0.33, 1.00, 3.00 and 9.00 mmol/kg/day. There were no compound-related deaths or ...

journal_title：Drug and chemical toxicology

authors： McCauley PT,Robinson M,Daniel FB,Olson GR

更新日期：1995-05-01 00:00:00

abstract：:This review summarizes the effects of more than 20 metals that, research has indicated, may influence male reproductive health. Though males lack an apparent, easily measurable reproductive cycle, progress has been made in evaluating tests to identify chemical hazards and estimate reproductive health risks. Some agent...

journal_title：Drug and chemical toxicology

authors： Sengupta P

更新日期：2013-07-01 00:00:00