Abstract:
:Cis-1,2-dichloroethylene was administered daily by corn oil gavage to male and female Sprague-Dawley rats at the following dose levels: 1.0, 3.0, 10.0 and 22.0 mmol/kg/day for 14 days. Doses gavaged during the 90-day subchronic study were 0.33, 1.00, 3.00 and 9.00 mmol/kg/day. There were no compound-related deaths or histopathological changes demonstrated. Significant increases in relative liver weights were seen after 14- and 90-days of treatment in both sexes. This study demonstrates some indication of toxicity at subacute and subchronic exposure levels as low as 0.33 mmol/kg/day. Implications of liver abnormalities were demonstrated at an exposure level of 1 mmol/kg/day while kidney abnormalities (relative weights) were demonstrated at an exposure level of 0.33 mmol/kg/day.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
McCauley PT,Robinson M,Daniel FB,Olson GRdoi
10.3109/01480549509014319subject
Has Abstractpub_date
1995-05-01 00:00:00pages
171-84issue
2-3eissn
0148-0545issn
1525-6014journal_volume
18pub_type
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