Pulmonary adenomas in A/J mice treated with silica.

abstract：:Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaco...

journal_title：Drug and chemical toxicology

authors： Ye Q,Liu H,Fang C,Liu Y,Liu X,Liu J,Zhang C,Zhang T,Peng C,Guo L

更新日期：2019-03-21 00:00:00

abstract：:Experiments were carried out to ascertain whether or not saffron (dried stigmas of Crocus sativus L.), a commonly used agent for flavoring and coloring food can exert modulatory effects on the in vivo genotoxicity of cisplatin (CIS), cyclophosphamide (CPH), mitomycin C (MMC) and urethane (URE). For this purpose, Swiss...

journal_title：Drug and chemical toxicology

authors： Premkumar K,Abraham SK,Santhiya ST,Gopinath PM,Ramesh A

更新日期：2001-11-01 00:00:00

abstract：:Many pharmaceuticals are administered to children and adults as sprays provided in nebulizers or metered-dose inhalers. Stress associated with possible eye irritation and injury attributable to exposure to vapors and particulates during the required safety testing procedures of such medicines is a potential confoundin...

journal_title：Drug and chemical toxicology

authors： Rothenberg SJ,Martin MM,Sherer KI,Parker RM,Dearlove GE,Christian MS

更新日期：1998-08-01 00:00:00

abstract：:Lead (Pb), a known environmental toxicant, adversely affects almost all organ systems. In this study, we investigated the effects of maternal lead exposure on fetal rat cerebellum. Female Sprague-Dawley rats were given lead nitrate in drinking water (0, 0.5, and 1%) for two weeks before conception, and during pregnanc...

journal_title：Drug and chemical toxicology

authors： Mousa AM,Al-Fadhli AS,Rao MS,Kilarkaje N

更新日期：2015-01-01 00:00:00

abstract：:In this study, the hepatoprotective activity of methanol bark extract of Alangium salviifolium (BEA) was evaluated for biochemical and histological parameters in swiss albino mice with CCl4-induced hepatotoxicity. The hepatomodulatory effect of two doses of BEA (20 and 50 mg/kg bw for 15 days by oral gavage) was asses...

journal_title：Drug and chemical toxicology

authors： Dhruve P,Nauman M,Kale RK,Singh RP

更新日期：2020-03-06 00:00:00

abstract：CONTEXT:Heparin-binding epidermal growth factor like growth factor (HB-EGF) is an emerging therapeutic for the regeneration of the tympanic membrane (TM). OBJECTIVE:Our aim was to determine whether the doses of HB-EGF delivered in a sustained release hydrogel into a middle ear mouse model, would be measurable in the s...

journal_title：Drug and chemical toxicology

authors： Santa Maria PL,Kim S,Yang YP

更新日期：2016-10-01 00:00:00

abstract：:Three alkyl diamines, which are by-products formed and separated during the production of hexamethylene diamine, have been tested, mostly for their acute toxicity. This paper reviews methodologies used and the results obtained from these three chemicals. All three tested [2-methyl-1,5-pentanediamine (2-MP), 1,3-diamin...

journal_title：Drug and chemical toxicology

authors： Kennedy GL Jr

更新日期：2007-01-01 00:00:00

abstract：:Adriamycin (ADR) causes morphological and functional alterations in mitochondrial structure in the heart. The study's aim was to determine whether there is a protective effect of selenium (Se) on ADR-induced cardiac damage. Rats were divided into four groups: The first group was injected saline intraperitoneally (i.p....

journal_title：Drug and chemical toxicology

authors： Dursun N,Taşkın E,Yerer Aycan MB,Sahin L

更新日期：2011-04-01 00:00:00

abstract：:The immunomodulatory effects of two plant regulators, cycloheximide and maleic hydrazide, were investigated by injecting the compounds twice weekly for 4 weeks in female Swiss Webster white mice. The animals were antigenically challenged with sheep red blood cells on day 24 of the study. Although humoral immunity was ...

journal_title：Drug and chemical toxicology

authors： Olson LJ,Hinsdill RD,Weltman DJ

更新日期：1983-01-01 00:00:00

abstract：:Cis-1,2-dichloroethylene was administered daily by corn oil gavage to male and female Sprague-Dawley rats at the following dose levels: 1.0, 3.0, 10.0 and 22.0 mmol/kg/day for 14 days. Doses gavaged during the 90-day subchronic study were 0.33, 1.00, 3.00 and 9.00 mmol/kg/day. There were no compound-related deaths or ...

journal_title：Drug and chemical toxicology

authors： McCauley PT,Robinson M,Daniel FB,Olson GR

更新日期：1995-05-01 00:00:00

abstract：:The nicotine metabolism of CYP2A6 (CYP2A6*1A,*1B, and *1C), and the cholecystokinin (CCK; which modulates the release of dopamine) and CCK-A receptor gene and personality traits for NEO-FFI, was investigated for the mechanism for elucidation of the smoking behavior in Japanese populations. The frequency of the CYP2A6*...

journal_title：Drug and chemical toxicology

authors： Iwahashi K,Aoki J

更新日期：2009-01-01 00:00:00

abstract：:This study investigated the effect of Thyme (Thymus vulgaris) leaf aqueous extract (TE) on purine and acetylcholine hydrolyzing enzyme activities and antioxidant status in the brain of 5-fluorouracil (5-FLU) administered rats. Sixty adult Wistar rats (210-225 g) were divided into Ten groups (n = 6). Group 1: received ...

journal_title：Drug and chemical toxicology

authors： Adefegha SA,Oyeleye SI,Akintemi A,Okeke BM,Oboh G

更新日期：2020-01-01 00:00:00

abstract：:1-((2-methyl-4-[(2-methyl phenyl)azo] phenyl)azo)-2-naphthalenol (C.I. Solvent Red 24) was prepared having a 14C label on the methyl group of the central ring and was administered in suspension intra-tracheally to a male and a female rat. After 96 hours in metabolism cages, the animals were sacrificed and 14C counted ...

journal_title：Drug and chemical toxicology

authors： Parent RA,Dressler I

更新日期：1979-01-01 00:00:00

abstract：:The Salmonella typhimurium/microsome assay is a widely used bacterial genotoxicity assay to test potential carcinogens. The aim of this work was to evaluate the mutagenic and antimutagenic activities with and without the addition of an extrinsic metabolic activation system of essential oils obtained from an aerial par...

journal_title：Drug and chemical toxicology

authors： Neffati A,Limem I,Kilani S,Bouhlel I,Skandrani I,Bhouri W,Ben Sghaier M,Boubaker J,Ledauphin J,Barillier D,Ghedira LC,Ghedira K

更新日期：2009-01-01 00:00:00

abstract：:The role of oxidative-stress as a mechanism of hepatotoxicity caused by combination of isoniazid (INH) and Rifampicin (RMP) was investigated in young growing rats. A successful model of hepatotoxicity was produced by giving 50 mg/kg/day each of INH and RMP in two weeks. Liver showed type II hepatocellular changes (mic...

journal_title：Drug and chemical toxicology

authors： Sodhi CP,Rana SV,Mehta SK,Vaiphei K,Attari S,Mehta S

更新日期：1997-08-01 00:00:00

abstract：:Neurodegenerative diseases affect millions of people. Major reasons behind the onset and progression of these diseases are still under investigation. Therefore, any approach that would treat/prevent progression is important. In this study, we aimed to investigate the potential protective effects of Psephellus pyrrhobl...

journal_title：Drug and chemical toxicology

authors： Taştan P,Armagan G,Dağcı T,Kıvçak B

更新日期：2019-09-02 00:00:00

abstract：:The present study was aimed to report the toxicity of the chlorpyrifos, an organophosphorus insecticide, with regard to histological and cytological effects through light and transmission electron microscopes in the gills of freshwater fish, Anabas testudineus. The fish were exposed to 0.125 (5% of 96 h LC50), 0.250 (...

journal_title：Drug and chemical toxicology

authors： Velmurugan B,Cengiz EI,Yolcu M,Uğurlu P,Selvanayagam M

更新日期：2020-07-01 00:00:00

abstract：:We investigated antigenotoxic and antioxidative effects of newly derivatized compound naringenin-oxime (NG-Ox) compared to its mother compound naringenin (NG) against oxidative damage induced by hydrogen peroxide (HP) in human peripheral blood mononuclear cells (PBMC). Antigenotoxic activity was assessed using alkalin...

journal_title：Drug and chemical toxicology

authors： Kocyigit A,Koyuncu I,Taskin A,Dikilitas M,Bahadori F,Turkkan B

更新日期：2016-01-01 00:00:00

abstract：:Gold nanorods (GNRs) are used for their wide variety of applications in various industries. There is a little availability of data related to toxicity and ecological implications of these GNRs. The study evaluated the oxidative stress induction following intra-tracheal instillation of 1 and 5 mg/kg b.w. doses of 10 an...

journal_title：Drug and chemical toxicology

authors： Lingabathula H,Yellu N

更新日期：2018-04-01 00:00:00

abstract：:In view of the ability of several phosphoesterases to hydrolyze organophosphates to toxic phenols, the bioactivation of bis[p-nitrophenyl]phosphate (BNPP) by the earthworm Lumbricus terrestris was investigated. In a contact toxicity test, BNPP was was less toxic than the metabolite p-nitrophenol (PNP), but more toxic ...

journal_title：Drug and chemical toxicology

authors： Park SC,Smith TJ,Bisesi MS

更新日期：1993-01-01 00:00:00

abstract：:In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were administered to the rats for 1 week. Serum biochemical cardiotoxicity parameters and tissue malond...

journal_title：Drug and chemical toxicology

authors： Saraçoğlu A,Temel HE,Ergun B,Colak O

更新日期：2009-01-01 00:00:00

abstract：:The toxicity of etephon and maleic hydrazide, used as plant growth regulators in agriculture, were reported as low in mammals in previous studies. However, in vitro cytotoxicity studies in mammalian cells are currently missing to understand their toxicity at molecular level. In the current study, the cytotoxicity of t...

journal_title：Drug and chemical toxicology

authors： Yurdakok B,Baydan E,Okur H,Gurcan IS

更新日期：2014-10-01 00:00:00

abstract：:Rotenone, an environmental toxin, triggers Parkinson's disease (PD)-like pathology through microglia-mediated neuronal death. The effects and molecular mechanisms of flavonoid luteolin against rotenone-induced toxicity was assessed in microglial BV2 cells. Cells were pretreated with luteolin (1-50 µM) for 12 h and the...

journal_title：Drug and chemical toxicology

authors： Elmazoglu Z,Yar Saglam AS,Sonmez C,Karasu C

更新日期：2020-01-01 00:00:00

abstract：:Modafinil is used for the treatment of various sleep disorders; however, its usage among healthy individuals is also increasing. There are a limited number of cardiovascular side effects, including ischemic T-wave changes, dyspnea, hypertension, and tachycardia in the literature. Our research aimed to investigate the ...

journal_title：Drug and chemical toxicology

authors： Canyurt D,Tanriverdi LH,Ozhan O,Cansel M,Parlakpinar H,Vardi N,Cigremis Y,Yildiz A,Karaca Y,Yasar S,Acet A

更新日期：2020-08-11 00:00:00

abstract：:In May 1993, Administrative Browner of the U.S. Environmental Protection Agency (USEPA) announced that an indirect exposure health risk assessment was required for all hazardous waste combustion facilities seeking a Resource Conservation and Recovery Act permit. These types of risk assessments evaluate the health and ...

journal_title：Drug and chemical toxicology

authors： Gaborek BJ

更新日期：2000-02-01 00:00:00

abstract：:The teratogenicity of p-tert-butylphenol formaldehyde resin, novolak type, (PTBP-FR) was examined in Wistar rats. Pregnant rats were fed diets containing 0, 2.5, 5 or 10% of PTBP-FR ad libitum from day 6 to day 15 of pregnancy. Maternal toxicity, as evidenced by a decreased maternal body weight gain and food consumpti...

journal_title：Drug and chemical toxicology

authors： Itami T,Ema M,Kawasaki H

更新日期：1993-01-01 00:00:00

abstract：:A 1-year chronic toxicity study was conducted in which rhesus monkeys (4/sex/dose) were given daily doses of 0, 3, 10, or 25 mg zatosetron/kg by nasogastric intubation. Clinical signs of toxicity characterized by salivation, diarrhea or soft stools, and/or emesis occurred in animals that received 10 or 25 mg/kg of zat...

journal_title：Drug and chemical toxicology

authors： Bendele A,Means J,Shoufler J,Schmalz C,Hanasono G,Symanowski J,Adams E

更新日期：1995-02-01 00:00:00

abstract：:In this study, the effects of a neonicotinoid insecticide acetamiprid on the sciatic nerve of Rana ridibunda were investigated by using electrophysiological and histological methods. A total of 35 preparations of sciatic nerve isolated from 35 frogs (Nervus ischiadicus) were used in the experiments. Experiments were d...

journal_title：Drug and chemical toxicology

authors： Çamlıca Y,Bediz SC,Çömelekoğlu Ü,Yilmaz ŞN

更新日期：2019-05-01 00:00:00

abstract：:A toxicity Evaluation of DDT and dieldrin was conducted using Japanese Quail. The effects of feeding DDT (5 and 50 ppm of diet) and dieldrin (0.1 and 1.0 ppm of diet) in this four generation study (parental, F1, F2 and F3) were examined in terms of growth, viability, and/or reproduction of offspring. Ten groups (inclu...

journal_title：Drug and chemical toxicology

authors： Shellenberger TE

更新日期：1978-01-01 00:00:00

abstract：:The potential maternal and developmental toxicity of cyclododecatriene (CDDT) was assessed in rats. Groups of 22 time-mated female Crl:CD (SD) BR rats were exposed by inhalation (whole-body, 6 h/day) to either 0 (control), 10, 25, or 67 ppm CDDT over days 6-20 of gestation (days 6-20 G); the day of copulation plug det...

journal_title：Drug and chemical toxicology

authors： Munley SM,Kelly DP,Kennedy GL Jr

更新日期：2003-08-01 00:00:00