Evaluation of the potential developmental toxicity of cyclododecatriene (CDDT).

abstract：:As a measure of glutathione (GSH) conjugation, urinary, fecal and biliary excretion of thioethers and hepatic GSH content were measured in rhesus monkeys following administration of single doses of naphthalene and diethylmaleate (DEM). Naphthalene had little or no effect on hepatic GSH content and the excretion of thi...

journal_title：Drug and chemical toxicology

authors： Rozman K,Summer KH,Rozman T,Greim H

更新日期：1982-01-01 00:00:00

abstract：:This study was designed to test the pulmonary tumor response to intratracheally instilled silica in Strain A mice. Urethane was used as a positive control. Silica treatment was utilized to evaluate the effect of a potent fibrinogen on pulmonary adenoma formation in this unique animal model. Urethane produced an increa...

journal_title：Drug and chemical toxicology

authors： McNeill DA,Chrisp CE,Fisher GL

更新日期：1990-01-01 00:00:00

abstract：:This study investigated the effect of Thyme (Thymus vulgaris) leaf aqueous extract (TE) on purine and acetylcholine hydrolyzing enzyme activities and antioxidant status in the brain of 5-fluorouracil (5-FLU) administered rats. Sixty adult Wistar rats (210-225 g) were divided into Ten groups (n = 6). Group 1: received ...

journal_title：Drug and chemical toxicology

authors： Adefegha SA,Oyeleye SI,Akintemi A,Okeke BM,Oboh G

更新日期：2020-01-01 00:00:00

abstract：:The availability of tissue glutathione (GSH) appears to depend upon a balance between tissue concentrations, the rate of reactive metabolite formation and the re-synthesis of GSH. To test this hypothesis, diethyl maleate (DEM, 5.8 mmol/kg bw) was administered intraperitoneally to male and female mice, hamsters, rats a...

journal_title：Drug and chemical toxicology

authors： Ecobichon DJ

更新日期：1984-01-01 00:00:00

abstract：:Pachira aquatica is a species used for medicinal and food purposes and has numerous phytochemicals that may have systemic toxic effects and damage to genetic material. This study aimed to evaluate acute and short-term oral toxicity, as well as genotoxic and clastogenic effects of oil extracted from P. aquatica (PASO) ...

journal_title：Drug and chemical toxicology

authors： Marcelino JM,Villas Boas GR,Cunha M,Deus Júnior R,Castro LH,Araújo FH,Traesel GK,Dos Santos AC,Souza RI,Paes M,Gubert P,Guterres ZDR,de Lima FF,Silva T,Silva RC,Cardoso CAL,Argandoña EJ,Macorini LF,Oesterreich SA

更新日期：2020-11-30 00:00:00

abstract：:A large number of cationic amphiphilic drugs (CADs) are known to cause phospholipidosis (PLD) in vivo. In the present study, we have built upon our previous findings to further qualify the use of a fluorescently labeled phospholipid-based cell-culture assay to detect PLD-inducing drugs. In this paper, we demonstrate t...

journal_title：Drug and chemical toxicology

authors： Nioi P,Pardo ID,Snyder RD

更新日期：2008-01-01 00:00:00

abstract：:Chemical pretreatment is effective against a 2 LD50 challenge of soman, sarin or VX or a 5 LD50 challenge of tabun. Chemical pretreatment followed by post challenge therapy should be effective against greater levels of agent. Such tests in guinea pigs are reported here; pretreatment regimens (PRGs) consisted of physos...

journal_title：Drug and chemical toxicology

authors： Lennox WJ,Harris LW,Anderson DR,Solana RP,Murrow ML,Wade JV

更新日期：1992-01-01 00:00:00

abstract：:The objective of the present study was to evaluate the oxidative stress potential of low-level organophosphate fenthion exposure with the modulatory effect of buthionine sulfoximine in the liver of Cyprinus carpio L. The fish were exposed to 20% of 96-hour LC(50) of fenthion for 24 and 96 hours. Total and oxidized glu...

journal_title：Drug and chemical toxicology

authors： Uner N,Sevgiler Y,Piner P,Durmaz H

更新日期：2008-01-01 00:00:00

abstract：:Cadmium (Cd) is a ubiquitous non-essential environmental and industrial toxicant that affects various organs in humans and experimental animals. Robust evidence confirms the contribution of oxidative stress to the pathogenesis of Cd-induced hepatic damage. Potent polyphenols found in virgin coconut oil (VCO) are free ...

journal_title：Drug and chemical toxicology

authors： Famurewa AC,Ugwu-Ejezie CS,Iyare EE,Folawiyo AM,Maduagwuna EK,Ejezie FE

更新日期：2019-04-25 00:00:00

abstract：:Hexachloroethane (HCE) was fed to Fischer 344 rats at approximate doses of 0, 1, 15 or 62 mg/kg/day for 16 weeks. Selected tissues were assayed at termination for HCE content. Histopathological examination identified the kidney as the primary target organ with male rats more sensitive than female rats. The kidney conc...

journal_title：Drug and chemical toxicology

authors： Gorzinski SJ,Nolan RJ,McCollister SB,Kociba RJ,Mattsson JL

更新日期：1985-01-01 00:00:00

abstract：:The Salmonella typhimurium/microsome assay is a widely used bacterial genotoxicity assay to test potential carcinogens. The aim of this work was to evaluate the mutagenic and antimutagenic activities with and without the addition of an extrinsic metabolic activation system of essential oils obtained from an aerial par...

journal_title：Drug and chemical toxicology

authors： Neffati A,Limem I,Kilani S,Bouhlel I,Skandrani I,Bhouri W,Ben Sghaier M,Boubaker J,Ledauphin J,Barillier D,Ghedira LC,Ghedira K

更新日期：2009-01-01 00:00:00

abstract：:This study aimed at comparing the cytotoxicity of a new octenidine mouth rinse (MR) on gingival fibroblasts and epithelial cells using different established MRs. Octenidol (OCT), Chlorhexidine 0.2% (CHX), Meridol (MER), Oral B (OB), and control (PBS only) were used. Human primary gingival fibroblasts (HGFIBs) and huma...

journal_title：Drug and chemical toxicology

authors： Schmidt J,Zyba V,Jung K,Rinke S,Haak R,Mausberg RF,Ziebolz D

更新日期：2018-04-01 00:00:00

abstract：:Genotoxicity of nimesulide (NM) was evaluated by employing bone marrow (BM) chromosomal aberration (CA) and micronucleus assays in Swiss albino mice. For BM CA assay, mice of either sex were treated orally with 1.5, 2.5 and 5 mg body weight solution of NM in 0.2 mL of 0.05% CMC (carboxy methyl cellulose) daily for 4, ...

journal_title：Drug and chemical toxicology

authors： Tripathi R,Tripathi P,Pancholi SS,Patel CN

更新日期：2014-07-01 00:00:00

abstract：:The purpose of this research was to evaluate the efficacy of carsil (CAR) either alone or in combination with α-tocopherol (α-TOCO) and/or turmeric (TUMR) against tetrachloromethane (TCM)-induced cardiomyocyte injury in rats. Administration of CAR either alone or in combination with α-TOCO and/or TUMR post-TCM injecti...

journal_title：Drug and chemical toxicology

authors： Alshanwani AR,Faddah LM,Hagar H,Alhusaini AM,Shaheen S,Mohammad RA,Alharbi FMB,AlHarthii A,Badr AM

更新日期：2020-10-15 00:00:00

abstract：:The median lethal dose (LD50) of chymopapain B in mice was 82 mg/kg (22,000 units/kg) with 95% confidence limits of 75-90 mg/kg (20, 122-24, 146 units/kg) and in rats 92 (24,683 units/kg) with 95% confidence limits of 83-102 mg/kg (22,268-27, 366 units/kg). The mechanism of toxicity was hemorrhage due to destruction o...

journal_title：Drug and chemical toxicology

authors： Simmons JW,Upman PJ,Stavinoha WB

更新日期：1984-01-01 00:00:00

abstract：:During a preclinical safety evaluation study, an indication of ocular toxicity was noted in beagle dogs receiving orally (gelatin capsules) once a day, 7 days a week for, respectively, 7 and 91 days, 10 mg/kg/day of Lortalamine, a new non-tricyclic anti-depressant compound. Lortalamine treated dogs showed, progressive...

journal_title：Drug and chemical toxicology

authors： Mally C,Thiebault JJ

更新日期：1990-01-01 00:00:00

abstract：:Neurodegenerative diseases affect millions of people. Major reasons behind the onset and progression of these diseases are still under investigation. Therefore, any approach that would treat/prevent progression is important. In this study, we aimed to investigate the potential protective effects of Psephellus pyrrhobl...

journal_title：Drug and chemical toxicology

authors： Taştan P,Armagan G,Dağcı T,Kıvçak B

更新日期：2019-09-02 00:00:00

abstract：:Butea monosperma (Lam.) Taub. is an ethnomedicinal tree of remedial value in the treatment of diabetes, bone fractures, and liver and neurological disorders. However, the information available on DNA-protective and anti-proliferative potential of bark of this tree is scarce. In the present study, the extract/fractions...

journal_title：Drug and chemical toxicology

authors： Kaur V,Kumar M,Kumar A,Kaur S

更新日期：2020-07-01 00:00:00

abstract：:The effect of a novel phosphorothionate, the methyl ester of 2-butenoic acid-3-diethoxy phosphinothioyl (RPR-II) was studied on membrane bound target enzymes Acid (AcP) and Alkaline (AkP) Phosphatases in different tissues of male and female albino Wistar rats. Three sub-chronic doses 0.014 (low), 0.028 (medium) and 0....

journal_title：Drug and chemical toxicology

authors： Rahman MF,Siddiqui MK,Jamil K

更新日期：2000-08-01 00:00:00

abstract：:A Type II pyrethroid pesticide β-cypermethrin is widely used in agriculture and domestic applications for pest control. However, the effect of β-cypermethrin on the glutamate neurotransmitter has not been well-documented. In the current study, mice were treated with 20, 40, or 80 mg/kg β-cypermethrin by a single oral ...

journal_title：Drug and chemical toxicology

authors： Cao D,Chen N,Zhu C,Zhao Y,Liu L,Yang J,An L

更新日期：2015-01-01 00:00:00

abstract：:An automatic system was developed to monitor continuously the colonic temperature of laboratory animals during inhalation exposure to toxic chemicals. It includes: an automatic switchbox, a control circuit, a recorder and a digital voltmeter. The system was calibrated for different temperature ranges and used for a ye...

journal_title：Drug and chemical toxicology

authors： Laham S,Schrader K,Symonds G,Curtin W

更新日期：1978-01-01 00:00:00

abstract：:Adriamycin (ADR) causes morphological and functional alterations in mitochondrial structure in the heart. The study's aim was to determine whether there is a protective effect of selenium (Se) on ADR-induced cardiac damage. Rats were divided into four groups: The first group was injected saline intraperitoneally (i.p....

journal_title：Drug and chemical toxicology

authors： Dursun N,Taşkın E,Yerer Aycan MB,Sahin L

更新日期：2011-04-01 00:00:00

abstract：:The status of brain antioxidant enzymes and glutathione in methacrylonitrile (MeAN)-intoxicated Wistar rats was correlated with the levels of lipid peroxidation products. Optimum changes were observed 30 min and 60 min after oral administration of MeAN at dosages of 50 mg/kg body weight per day (0.25 LD50) and 100 mg/...

journal_title：Drug and chemical toxicology

authors： Zeenath Unnisa A,Niranjali Devaraj S

更新日期：2005-01-01 00:00:00

abstract：:The role of oxidative-stress as a mechanism of hepatotoxicity caused by combination of isoniazid (INH) and Rifampicin (RMP) was investigated in young growing rats. A successful model of hepatotoxicity was produced by giving 50 mg/kg/day each of INH and RMP in two weeks. Liver showed type II hepatocellular changes (mic...

journal_title：Drug and chemical toxicology

authors： Sodhi CP,Rana SV,Mehta SK,Vaiphei K,Attari S,Mehta S

更新日期：1997-08-01 00:00:00

abstract：:The quantities of selenium, tar and nicotine present in mainstream (MS) and sidestream (SS) smoke of machine-smoked cigarettes was studied. The cigarettes were prepared from tobacco purposely cultured on fly ash-amended soil so as to increase its selenium concentration. Selenium concentration was found to be the same ...

journal_title：Drug and chemical toxicology

authors： Gutenmann WH,Lisk DJ,Shane BS,Hoffmann D,Adams JD

更新日期：1987-01-01 00:00:00

abstract：:A toxicity Evaluation of DDT and dieldrin was conducted using Japanese Quail. The effects of feeding DDT (5 and 50 ppm of diet) and dieldrin (0.1 and 1.0 ppm of diet) in this four generation study (parental, F1, F2 and F3) were examined in terms of growth, viability, and/or reproduction of offspring. Ten groups (inclu...

journal_title：Drug and chemical toxicology

authors： Shellenberger TE

更新日期：1978-01-01 00:00:00

abstract：:The cross-reaction patterns of selected acrylate and methacrylate esters were investigated using the guinea pig maximization test. Methacrylates were less potent sensitizers than acrylates. Cross-sensitization was found between (meth)acrylates with closely related core structures, most extensively between hydroxyethyl...

journal_title：Drug and chemical toxicology

authors： Clemmensen S

更新日期：1984-01-01 00:00:00

abstract：:While it is well recognized that the combination of amoxicillin and clavulanic acid has been associated with hepatic adverse events, there are only a few reports about amoxicillin alone causing hepatic toxicity. We describe a 34-year-old woman who developed severe cholestatic hepatitis following amoxicillin treatment....

journal_title：Drug and chemical toxicology

authors： Chaabane NB,Safer L,Njim L,Zakhama A,Saffar H

更新日期：2011-10-01 00:00:00

abstract：:Acute and repeated oral and dermal rat toxicology studies of standard designs were conducted on four methyl ethyl ketoxime (MEKO) silanes and four methyl isobutyl ketoxime (MIBKO) silanes. Each compound contained either MEKO or MIBKO groups (but not both) and either a single methyl, vinyl, or phenyl group (trifunction...

journal_title：Drug and chemical toxicology

authors： Derelanko MJ,Rusch GM

更新日期：2008-01-01 00:00:00

abstract：:The effects of various levels of dietary iron on hepatic lipid peroxidation (malondialdehyde [MDA] content), reduced glutathione (GSH) and GSH peroxidase (GSH-PX) activity as well as liver and body weights of female rats following TCDD administration were examined. Rats were fed diets containing deficient (6 ppm), nor...

journal_title：Drug and chemical toxicology

authors： al-Turk WA,Shara MA,Mohammadpour H,Stohs SJ

更新日期：1988-01-01 00:00:00