The beneficial effects of antioxidants combination on cardiac injury induced by tetrachloromethane.

abstract：:Copper (Cu) is a heavy metal with the ability to induce, at high levels, neurobehavioral alterations, and oxidative stress (OS). On the other hand, melatonin (Mel) is a neurohormone that protects neurons from OS and has a modulatory effect on several behavioral processes. The present experiment was aimed to examine th...

journal_title：Drug and chemical toxicology

authors： Lamtai M,Zghari O,Azirar S,Ouakki S,Mesfioui A,El Hessni A,Berkiks I,Marmouzi I,Ouichou A

更新日期：2021-01-07 00:00:00

abstract：CONTEXT:Celtis glabrata is used in Turkey for the treatment of various health disorders. OBJECTIVE:The acetone, chloroform, ethanol, and methanol extracts of C. glabrata leaf, fruit, and seed were investigated to evaluate their antimutagenic activities. MATERIAL AND METHODS:The antimutagenicity of these extracts was ...

journal_title：Drug and chemical toxicology

authors： Akin D,Durak Y,Uysal A,Gunes E,Aladag MO

更新日期：2016-01-01 00:00:00

abstract：:Short-term lymphocyte cultures from human peripheral blood samples were incubated with various aliquots of the carbofuran pesticide. After 48 h of initiation and 24 h of exposure to the carbofuran pesticide aliquots, it was seen that carbofuran caused an increase in the frequency of chromosomal aberrations, and the in...

journal_title：Drug and chemical toxicology

authors： Naravaneni R,Jamil K

更新日期：2005-01-01 00:00:00

abstract：:This study was designed to test the pulmonary tumor response to intratracheally instilled silica in Strain A mice. Urethane was used as a positive control. Silica treatment was utilized to evaluate the effect of a potent fibrinogen on pulmonary adenoma formation in this unique animal model. Urethane produced an increa...

journal_title：Drug and chemical toxicology

authors： McNeill DA,Chrisp CE,Fisher GL

更新日期：1990-01-01 00:00:00

abstract：:A Type II pyrethroid pesticide β-cypermethrin is widely used in agriculture and domestic applications for pest control. However, the effect of β-cypermethrin on the glutamate neurotransmitter has not been well-documented. In the current study, mice were treated with 20, 40, or 80 mg/kg β-cypermethrin by a single oral ...

journal_title：Drug and chemical toxicology

authors： Cao D,Chen N,Zhu C,Zhao Y,Liu L,Yang J,An L

更新日期：2015-01-01 00:00:00

abstract：:A comparison of the fertility and cytogenetic analyses and the combination of both techniques as generally used in the heritable translocation assay was conducted with triethylenemelamine (TEM). CD-1 mice were used as the F0 generation and were divided into two groups that received i.p. either distilled water (control...

journal_title：Drug and chemical toxicology

authors： Moreland FM,Sheu CJ

更新日期：1983-01-01 00:00:00

abstract：:MG132, as a proteasome inhibitor, has been shown to induce apoptotic cell death through the formation of reactive oxygen species (ROS). In this study, we investigated the effects of MG132 and/or MAPK inhibitors on As4.1 juxtaglomerular cells in relation to cell growth, cell death, ROS, and glutathione (GSH) levels. MG...

journal_title：Drug and chemical toxicology

authors： Han YH,Kim SZ,Kim SH,Park WH

更新日期：2010-10-01 00:00:00

abstract：CONTEXT:Caffeine is the most widely consumed nervous stimulant that induces oxidative-mediated apoptosis and cell cycle arrest in neural cells. Due to low toxicity, high accumulation in neural cells, reduction of the free fatty acids and antioxidant property, l-carnitine (LC) is an interesting compound to be used in vi...

journal_title：Drug and chemical toxicology

authors： Bavari M,Tabandeh MR,Najafzadeh Varzi H,Bahramzadeh S

更新日期：2016-01-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) expression, in response to various stimuli, has been generally reported to protect against cellular stress. However, we previously demonstrated simvastatin-induced HO-1-exaggerated nuclear factor kappa beta (NF-κβ) activation and superoxide production on exposure to lipopolysaccharide (LPS). Th...

journal_title：Drug and chemical toxicology

authors： Hsieh CH,Jeng JC,Hsieh MW,Chen YC,Lu TH,Rau CS,Jeng SF

更新日期：2011-01-01 00:00:00

abstract：:The relationship between lead concentration in the dry film of lead based paints applied to steel bulkheads aboard ship, the lead concentration found in the air when the paint is removed by mechanical means, and blood lead concentrations of workers involved in lead based paint removal has not been well characterized. ...

journal_title：Drug and chemical toxicology

authors： Alexander WK,Carpenter RL,Kimmel EC

更新日期：1999-02-01 00:00:00

abstract：:The role of oxidative-stress as a mechanism of hepatotoxicity caused by combination of isoniazid (INH) and Rifampicin (RMP) was investigated in young growing rats. A successful model of hepatotoxicity was produced by giving 50 mg/kg/day each of INH and RMP in two weeks. Liver showed type II hepatocellular changes (mic...

journal_title：Drug and chemical toxicology

authors： Sodhi CP,Rana SV,Mehta SK,Vaiphei K,Attari S,Mehta S

更新日期：1997-08-01 00:00:00

abstract：:Hepatic cysteamine and non-protein sulfhydryl (NPSH) levels were determined in galactosamine (GAL)-poisoned rats following hepatoprotective cystamine or cysteamine treatments to determine whether alterations of hepatic NPSH status could contribute to their observed protective actions. D(+)-Galactosamine HC1 (400 mg/kg...

journal_title：Drug and chemical toxicology

authors： MacDonald JR,Gandolfi AJ,Sipes IG

更新日期：1985-01-01 00:00:00

abstract：:We designed this study to identify the factors associated with time to successful weaning in mechanically ventilated organophosphate (OP)-poisoned patients as the primary outcomes while duration of mechanical ventilation (MV) support, intensive care unit (ICU), and hospital length of stay (LOS) and in-hospital mortali...

journal_title：Drug and chemical toxicology

authors： Abdel Hamid WG,Mansour W,Nafea OE

更新日期：2021-01-12 00:00:00

abstract：:Modafinil is used for the treatment of various sleep disorders; however, its usage among healthy individuals is also increasing. There are a limited number of cardiovascular side effects, including ischemic T-wave changes, dyspnea, hypertension, and tachycardia in the literature. Our research aimed to investigate the ...

journal_title：Drug and chemical toxicology

authors： Canyurt D,Tanriverdi LH,Ozhan O,Cansel M,Parlakpinar H,Vardi N,Cigremis Y,Yildiz A,Karaca Y,Yasar S,Acet A

更新日期：2020-08-11 00:00:00

abstract：:Oxidative stress is produced under diabetic conditions and is likely involved in the progression of pancreatic damage found in diabetes. This study was undertaken to evaluate the protective effect of Aegle marmelos leaf extract, a medicinal plant, on the tissue antioxidant defense system and lipid peroxidative status ...

journal_title：Drug and chemical toxicology

authors： Narendhirakannan RT,Subramanian S

更新日期：2010-04-01 00:00:00

abstract：:It is generally thought that residual unpolymerized (meth)acrylic monomers commonly found in pressure sensitive adhesive tapes for medical use may cause dermal irritation, but a systematic study has never been carried out. Therefore, we assessed the potential dermal irritating effect of residual (meth)acrylic monomers...

journal_title：Drug and chemical toxicology

authors： Tokumura F,Matsui T,Suzuki Y,Sado M,Taniguchi M,Kobayashi I,Kamiyama M,Suda S,Nakamura A,Yamazaki Y,Yamori A,Igarashi R,Kawai J,Oka K

更新日期：2010-01-01 00:00:00

abstract：:The present study was aimed at exploring the effect of monensin, an antibiotic carboxylic polyether ionophore specific for Na(+), on the structural, chemical, and physiological changes of the epididymal sperm of Wistar rats. Animals received monensin at the dose of 3.5 mg/kg body weight daily orally for 70 days, a tre...

journal_title：Drug and chemical toxicology

authors： Sharma P,Kanwar SS,Sanyal SN

更新日期：2013-01-01 00:00:00

abstract：:The availability of tissue glutathione (GSH) appears to depend upon a balance between tissue concentrations, the rate of reactive metabolite formation and the re-synthesis of GSH. To test this hypothesis, diethyl maleate (DEM, 5.8 mmol/kg bw) was administered intraperitoneally to male and female mice, hamsters, rats a...

journal_title：Drug and chemical toxicology

authors： Ecobichon DJ

更新日期：1984-01-01 00:00:00

abstract：:Pachira aquatica is a species used for medicinal and food purposes and has numerous phytochemicals that may have systemic toxic effects and damage to genetic material. This study aimed to evaluate acute and short-term oral toxicity, as well as genotoxic and clastogenic effects of oil extracted from P. aquatica (PASO) ...

journal_title：Drug and chemical toxicology

authors： Marcelino JM,Villas Boas GR,Cunha M,Deus Júnior R,Castro LH,Araújo FH,Traesel GK,Dos Santos AC,Souza RI,Paes M,Gubert P,Guterres ZDR,de Lima FF,Silva T,Silva RC,Cardoso CAL,Argandoña EJ,Macorini LF,Oesterreich SA

更新日期：2020-11-30 00:00:00

abstract：:S-[3-carbamoylsulfanyl-2-(dimethylamino)propyl] carbamothioate (Cartap) (CAS number: 15263-52-2) is a synthetic insecticide of thiocarbamates group that is extensively used in field of agriculture for controlling of several pests like rice stem borer, leaf folder pests in paddy field and diamond back moth, aphids in c...

journal_title：Drug and chemical toxicology

authors： Sharma LP,Kadve MP,Lingaraju MC,Telang AG

更新日期：2021-03-01 00:00:00

abstract：:Doxorubicin (DOX), a highly active chemotherapeutic drug, faces limitations in clinical application due to severe cardiotoxic effects (mainly through increased oxidative stress). Therefore, its effect is exacerbated in subjects with ischemic heart disease. We have recently reported that saffron extract (SAF), a natura...

journal_title：Drug and chemical toxicology

authors： Chahine N,Nader M,Duca L,Martiny L,Chahine R

更新日期：2016-01-01 00:00:00

abstract：:The teratogenicity of p-tert-butylphenol formaldehyde resin, novolak type, (PTBP-FR) was examined in Wistar rats. Pregnant rats were fed diets containing 0, 2.5, 5 or 10% of PTBP-FR ad libitum from day 6 to day 15 of pregnancy. Maternal toxicity, as evidenced by a decreased maternal body weight gain and food consumpti...

journal_title：Drug and chemical toxicology

authors： Itami T,Ema M,Kawasaki H

更新日期：1993-01-01 00:00:00

abstract：:The tricyclic antidepressant imipramine was instilled directly onto the lung surface of experimental rats in specific low doses (0.025 - 0.60 mg/kg body weight) and the animals were sacrificed at time intervals from 2 - 21 days after a single instillation. Such treatment caused changes almost exclusively confined to t...

journal_title：Drug and chemical toxicology

authors： Lewis RW,Harwood JL,Richards RJ

更新日期：1983-01-01 00:00:00

abstract：:Many steps are required to convert a normal cell into a cancerous one. The cancer cell must be able to multiply under conditions that a normal cell would not and to invade surrounding tissue and spread throughout the body. Both genetic changes, such as activation of oncogenes or inactivation of tumor suppressor genes,...

journal_title：Drug and chemical toxicology

authors： Couch DB

更新日期：1996-08-01 00:00:00

abstract：:Phospholipidosis is the excessive accumulation of intracellular phospholipids in cell lysosomes. Drugs that induce this disease often share common physiochemical properties and are collectively classified as cationic amphiphilic drugs (CADs). Although the cause of phospholipidosis and morphologic appearance of affecte...

journal_title：Drug and chemical toxicology

authors： Piccotti JR,LaGattuta MS,Knight SA,Gonzales AJ,Bleavins MR

更新日期：2005-01-01 00:00:00

abstract：:Celecoxib has been shown to have an antitumor effect in previous studies, but the mechanisms are unclear. Ca(2+) is a key second messenger in most cells. The effect of celecoxib on cytosolic free Ca(2+) concentrations ([Ca(2+)](i)) in human suspended PC3 prostate cancer cells was explored by using fura-2 as a fluoresc...

journal_title：Drug and chemical toxicology

authors： Wang JL,Lin KL,Chou CT,Kuo CC,Cheng JS,Hsu SS,Chang HT,Tsai JY,Liao WC,Lu YC,Chen IS,Liu SI,Jan CR

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Parkinsonism describes Parkinson's disease and other associated degenerative changes in the brain resulting in movement disorders. The motor cortex, extrapyramidal tracts and nigrostriatal tract are brain regions forming part of the motor neural system and are primary targets for drug or chemotoxins induced ...

journal_title：Drug and chemical toxicology

authors： Ogundele OM,Nanakumo ET,Ishola AO,Obende OM,Enye LA,Balogun WG,Cobham AE,Abdulbasit A

更新日期：2015-10-01 00:00:00

abstract：:Cardiotoxicity is commonly associated with cocaine abuse. Previous studies have indicated that cocaine alters myocardial mitochondrial function. This study was undertaken to investigate the effect of cocaine on activity of the mitochondrial electron transport chain in cultures of neonatal rat cardiomyocytes and in iso...

journal_title：Drug and chemical toxicology

authors： Yuan C,Acosta D Jr

更新日期：2000-05-01 00:00:00

abstract：:The Salmonella typhimurium/microsome assay is a widely used bacterial genotoxicity assay to test potential carcinogens. The aim of this work was to evaluate the mutagenic and antimutagenic activities with and without the addition of an extrinsic metabolic activation system of essential oils obtained from an aerial par...

journal_title：Drug and chemical toxicology

authors： Neffati A,Limem I,Kilani S,Bouhlel I,Skandrani I,Bhouri W,Ben Sghaier M,Boubaker J,Ledauphin J,Barillier D,Ghedira LC,Ghedira K

更新日期：2009-01-01 00:00:00

abstract：:Evidence suggests that the effect of heavy metals on neuroimmune cells lead to neurogenic inflammatory responses. In this study, immune cells [mast cells (MCs) and microglia] and pro-neuroinflammation cytokines (interleukin-1b and tumor necrosis factor-α) were assessed in the prefrontal lobe of rat brains exposed to t...

journal_title：Drug and chemical toxicology

authors： Afsordeh K,Sadeghi Y,Amini A,Namvarpour Z,Abdollahifar MA,Abbaszadeh HA,Aliaghaei A

更新日期：2019-03-01 00:00:00