Alterations of neuroimmune cell density and pro-inflammatory cytokines in response to thimerosal in prefrontal lobe of male rats.

abstract：:Copper (Cu) is a heavy metal with the ability to induce, at high levels, neurobehavioral alterations, and oxidative stress (OS). On the other hand, melatonin (Mel) is a neurohormone that protects neurons from OS and has a modulatory effect on several behavioral processes. The present experiment was aimed to examine th...

journal_title：Drug and chemical toxicology

authors： Lamtai M,Zghari O,Azirar S,Ouakki S,Mesfioui A,El Hessni A,Berkiks I,Marmouzi I,Ouichou A

更新日期：2021-01-07 00:00:00

abstract：:Experiments were carried out to ascertain whether or not saffron (dried stigmas of Crocus sativus L.), a commonly used agent for flavoring and coloring food can exert modulatory effects on the in vivo genotoxicity of cisplatin (CIS), cyclophosphamide (CPH), mitomycin C (MMC) and urethane (URE). For this purpose, Swiss...

journal_title：Drug and chemical toxicology

authors： Premkumar K,Abraham SK,Santhiya ST,Gopinath PM,Ramesh A

更新日期：2001-11-01 00:00:00

abstract：:Doxorubicin (DOX), a highly active chemotherapeutic drug, faces limitations in clinical application due to severe cardiotoxic effects (mainly through increased oxidative stress). Therefore, its effect is exacerbated in subjects with ischemic heart disease. We have recently reported that saffron extract (SAF), a natura...

journal_title：Drug and chemical toxicology

authors： Chahine N,Nader M,Duca L,Martiny L,Chahine R

更新日期：2016-01-01 00:00:00

abstract：:S-[3-carbamoylsulfanyl-2-(dimethylamino)propyl] carbamothioate (Cartap) (CAS number: 15263-52-2) is a synthetic insecticide of thiocarbamates group that is extensively used in field of agriculture for controlling of several pests like rice stem borer, leaf folder pests in paddy field and diamond back moth, aphids in c...

journal_title：Drug and chemical toxicology

authors： Sharma LP,Kadve MP,Lingaraju MC,Telang AG

更新日期：2021-03-01 00:00:00

abstract：:Chrysin (CH) is a natural flavone which possesses antioxidant, anti-cancer, and anti-inflammatory properties. The aim of the present study was to investigate the effects of CH on biochemical parameters, histopathological changes, and genotoxicity and hematological indices in diazinon (DZN)-induced toxicity in BALB/c m...

journal_title：Drug and chemical toxicology

authors： Zeinali M,Meybodi NT,Rezaee SA,Rafatpanah H,Hosseinzadeh H

更新日期：2018-07-01 00:00:00

abstract：:This study was conducted to evaluate the potential reproductive toxicity of epichlorohydrin in a one-generation reproduction toxicity study in compliance with OECD Test Guideline 415. Twenty-four male and female rats per group were given epichlorohydrin by gavage at 0, 3.3, 10, and 30 mg/kg/day. Males were dosed for 1...

journal_title：Drug and chemical toxicology

authors： Shin IS,Park NH,Lee JC,Kim KH,Moon C,Kim SH,Shin DH,Park SC,Kim HY,Kim JC

更新日期：2010-07-01 00:00:00

abstract：:Prolonged exposure to aluminum through occupational hazards or food/water intake has been linked to the occurrence of Alzheimer's disease (AD). This study aimed at investigating the neuroprotective effects of Gallic Acid (GA) against aluminum-chloride induced AD in adult Wistar rats. Twenty eight (28) adult Wistar rat...

journal_title：Drug and chemical toxicology

authors： Ogunlade B,Adelakun SA,Agie JA

更新日期：2020-04-24 00:00:00

abstract：:The quantities of selenium, tar and nicotine present in mainstream (MS) and sidestream (SS) smoke of machine-smoked cigarettes was studied. The cigarettes were prepared from tobacco purposely cultured on fly ash-amended soil so as to increase its selenium concentration. Selenium concentration was found to be the same ...

journal_title：Drug and chemical toxicology

authors： Gutenmann WH,Lisk DJ,Shane BS,Hoffmann D,Adams JD

更新日期：1987-01-01 00:00:00

abstract：:Hyperlipidemia causes lipotoxicity which prompts an inflammatory response linked to the development of cardiovascular diseases. Natural compounds have been receiving special attention for its potential to treat diseases, inexpensiveness, and safety. Guarana (Paullinia cupana) has demonstrated notable anti-inflammatory...

journal_title：Drug and chemical toxicology

authors： Ruchel JB,Bernardes VM,Braun JBS,Manzoni AG,Passos DF,Castilhos LG,Abdalla FH,de Oliveira JS,de Andrade CM,Casali EA,da Cruz IBM,Leal DBR

更新日期：2019-06-14 00:00:00

abstract：:Short-term lymphocyte cultures from human peripheral blood samples were incubated with various aliquots of the carbofuran pesticide. After 48 h of initiation and 24 h of exposure to the carbofuran pesticide aliquots, it was seen that carbofuran caused an increase in the frequency of chromosomal aberrations, and the in...

journal_title：Drug and chemical toxicology

authors： Naravaneni R,Jamil K

更新日期：2005-01-01 00:00:00

abstract：:During a preclinical safety evaluation study, an indication of ocular toxicity was noted in beagle dogs receiving orally (gelatin capsules) once a day, 7 days a week for, respectively, 7 and 91 days, 10 mg/kg/day of Lortalamine, a new non-tricyclic anti-depressant compound. Lortalamine treated dogs showed, progressive...

journal_title：Drug and chemical toxicology

authors： Mally C,Thiebault JJ

更新日期：1990-01-01 00:00:00

abstract：:Several studies documented the ameliorative effects of curcumin which plays a pivotal role in radical scavenging activities. It also participates in various cellular pathways and interacts with multiple targets. In the present study, we investigated the ameliorative effect of curcumin upon chromosomal genotoxicity ind...

journal_title：Drug and chemical toxicology

authors： Shah AJ,Prasanth Kumar S,Rao MV,Pandya HA

更新日期：2018-07-01 00:00:00

abstract：:Eight antineoplastic drugs were evaluated for their ability to induce mutation in the Ames Salmonella/microsome and the TK+/- mouse lymphoma assay. Dose response data were utilized to determine the relative potency of each of these drugs. They were then ranked based on this information. Vincristine, the most potent co...

journal_title：Drug and chemical toxicology

authors： Matheson D,Brusick D,Carrano R

更新日期：1978-01-01 00:00:00

abstract：:Three chemotoxins including dimethylnitrosamine (DMN), carbon tetrachloride (CCl4), and thioacetamide (TAA) are commonly used in hepatofibrotic models. We aimed to draw characteristics of histopathology and pro-fibrogenic cytokines including TGF-β, PDGF and CTGF among three models. Rats were divided into six groups an...

journal_title：Drug and chemical toxicology

authors： Park HJ,Kim HG,Wang JH,Choi MK,Han JM,Lee JS,Son CG

更新日期：2016-01-01 00:00:00

abstract：:The antioxidant and drug metabolizing potentials of Hibiscus anthocyanin extract in CCl(4)- induced oxidative damage of rat liver was investigated. Hibiscus anthocyanin extract effectively scavenge α-diphenyl-β-picrylhydrazyl (DPPH) radical, superoxide ion, and hydrogen peroxide. It produced a 92% scavenging effect of...

journal_title：Drug and chemical toxicology

authors： Ajiboye TO,Salawu NA,Yakubu MT,Oladiji AT,Akanji MA,Okogun JI

更新日期：2011-04-01 00:00:00

abstract：:This study assessed possible adverse immunological effects of trans-1,2-dichloroethylene (DCE) on random-bred CD-1 mice following 14 and 90 days of exposure. A 14-day range-finding study was performed on male mice by gavage at doses 1/10 and 1/100 the LD50 (210 and 21 mg/kg). No alterations in either humoral or cell-m...

journal_title：Drug and chemical toxicology

authors： Shopp GM Jr,Sanders VM,White KL Jr,Munson AE

更新日期：1985-01-01 00:00:00

abstract：:Gold nanorods (GNRs) are used for their wide variety of applications in various industries. There is a little availability of data related to toxicity and ecological implications of these GNRs. The study evaluated the oxidative stress induction following intra-tracheal instillation of 1 and 5 mg/kg b.w. doses of 10 an...

journal_title：Drug and chemical toxicology

authors： Lingabathula H,Yellu N

更新日期：2018-04-01 00:00:00

abstract：:This study was designed to investigate possible interference of Xenobiotics with SUMOylation in eukaryotic cells. To begin with, we docked 71 chemical structures from PubChem with human SUMO1 and UBC9 protein structures using Auto Dock 4.2 and Hex 6.3 and selected five compounds for binding studies in Surface Plasmon ...

journal_title：Drug and chemical toxicology

authors： Yarahalli Jayaram V,Baggavalli S,Reddy D,Sistla S,Malempati R

更新日期：2020-11-01 00:00:00

abstract：:As a measure of glutathione (GSH) conjugation, urinary, fecal and biliary excretion of thioethers and hepatic GSH content were measured in rhesus monkeys following administration of single doses of naphthalene and diethylmaleate (DEM). Naphthalene had little or no effect on hepatic GSH content and the excretion of thi...

journal_title：Drug and chemical toxicology

authors： Rozman K,Summer KH,Rozman T,Greim H

更新日期：1982-01-01 00:00:00

abstract：:The object of this study was to evaluate the toxicity of norbornene fluoroalcohol (NBFOH), which is used as an intermediate in the production of fluorinated monomers and polymers. NBFOH was evaluated for acute oral, dermal, and inhalation toxicity, dermal sensitization using the Local Lymph Node Assay (LLNA), mutagene...

journal_title：Drug and chemical toxicology

authors： DeLorme MP,Ladics GS,Donner EM,Wagner VO 3rd,Finlay C,Frame SR,Everds NE,Loveless SE

更新日期：2005-01-01 00:00:00

abstract：:Chemical pretreatment is effective against a 2 LD50 challenge of soman, sarin or VX or a 5 LD50 challenge of tabun. Chemical pretreatment followed by post challenge therapy should be effective against greater levels of agent. Such tests in guinea pigs are reported here; pretreatment regimens (PRGs) consisted of physos...

journal_title：Drug and chemical toxicology

authors： Lennox WJ,Harris LW,Anderson DR,Solana RP,Murrow ML,Wade JV

更新日期：1992-01-01 00:00:00

abstract：:The responses of atria isolated from four groups of rats: (a) control (air/H2O) and test animals treated with (b) 5 PPM nitrogen dioxide NO2 for 72 hours, (NO2/H2O), (c) 10% ethanol (ET) in water for 13 days, (air/ET), or (d) combination of NO2 and ET (NO2/ET). Isolated atria were tested with norepinephrine and dose r...

journal_title：Drug and chemical toxicology

authors： Early J,McGrath J,Messiha FS,Hughes MJ

更新日期：1983-01-01 00:00:00

abstract：:The purpose of this research was to evaluate the efficacy of carsil (CAR) either alone or in combination with α-tocopherol (α-TOCO) and/or turmeric (TUMR) against tetrachloromethane (TCM)-induced cardiomyocyte injury in rats. Administration of CAR either alone or in combination with α-TOCO and/or TUMR post-TCM injecti...

journal_title：Drug and chemical toxicology

authors： Alshanwani AR,Faddah LM,Hagar H,Alhusaini AM,Shaheen S,Mohammad RA,Alharbi FMB,AlHarthii A,Badr AM

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Parkinsonism describes Parkinson's disease and other associated degenerative changes in the brain resulting in movement disorders. The motor cortex, extrapyramidal tracts and nigrostriatal tract are brain regions forming part of the motor neural system and are primary targets for drug or chemotoxins induced ...

journal_title：Drug and chemical toxicology

authors： Ogundele OM,Nanakumo ET,Ishola AO,Obende OM,Enye LA,Balogun WG,Cobham AE,Abdulbasit A

更新日期：2015-10-01 00:00:00

abstract：:The frequency of dexamethasone-induced cleft palate in mouse fetuses was studied at four fixed times on day 13 of gestation. On day 18, the fetuses were examined for malformations and corticosterone concentration was additionally measured. Evidence of a diurnal rhythm in cleft palate frequency, as well as in corticost...

journal_title：Drug and chemical toxicology

authors： Sauerbier I

更新日期：1986-01-01 00:00:00

abstract：:The cytotoxic effect of caffeine on heart cells was evaluated in primary cultures of rat heart muscle (M) and endothelioid (E) cells. The cultures were exposed to 5, 10, or 20 mM caffeine for 6, 12, or 24 hours. As an index of cytotoxicity produced by the treatments, in situ changes in mitochondrial membrane fragility...

journal_title：Drug and chemical toxicology

authors： Acosta D,Anuforo D

更新日期：1977-01-01 00:00:00

abstract：:The immunomodulatory effects of two plant regulators, cycloheximide and maleic hydrazide, were investigated by injecting the compounds twice weekly for 4 weeks in female Swiss Webster white mice. The animals were antigenically challenged with sheep red blood cells on day 24 of the study. Although humoral immunity was ...

journal_title：Drug and chemical toxicology

authors： Olson LJ,Hinsdill RD,Weltman DJ

更新日期：1983-01-01 00:00:00

abstract：:The availability of tissue glutathione (GSH) appears to depend upon a balance between tissue concentrations, the rate of reactive metabolite formation and the re-synthesis of GSH. To test this hypothesis, diethyl maleate (DEM, 5.8 mmol/kg bw) was administered intraperitoneally to male and female mice, hamsters, rats a...

journal_title：Drug and chemical toxicology

authors： Ecobichon DJ

更新日期：1984-01-01 00:00:00

abstract：:An automatic system was developed to monitor continuously the colonic temperature of laboratory animals during inhalation exposure to toxic chemicals. It includes: an automatic switchbox, a control circuit, a recorder and a digital voltmeter. The system was calibrated for different temperature ranges and used for a ye...

journal_title：Drug and chemical toxicology

authors： Laham S,Schrader K,Symonds G,Curtin W

更新日期：1978-01-01 00:00:00

abstract：:Acute and repeated oral and dermal rat toxicology studies of standard designs were conducted on four methyl ethyl ketoxime (MEKO) silanes and four methyl isobutyl ketoxime (MIBKO) silanes. Each compound contained either MEKO or MIBKO groups (but not both) and either a single methyl, vinyl, or phenyl group (trifunction...

journal_title：Drug and chemical toxicology

authors： Derelanko MJ,Rusch GM

更新日期：2008-01-01 00:00:00