Ameliorative effects of curcumin towards cyclosporine-induced genotoxic potential: an in vitro and in silico study.

abstract：:1-((2-methyl-4-[(2-methyl phenyl)azo] phenyl)azo)-2-naphthalenol (C.I. Solvent Red 24) was prepared having a 14C label on the methyl group of the central ring and was administered in suspension intra-tracheally to a male and a female rat. After 96 hours in metabolism cages, the animals were sacrificed and 14C counted ...

journal_title：Drug and chemical toxicology

authors： Parent RA,Dressler I

更新日期：1979-01-01 00:00:00

abstract：:Acute and repeated oral and dermal rat toxicology studies of standard designs were conducted on four methyl ethyl ketoxime (MEKO) silanes and four methyl isobutyl ketoxime (MIBKO) silanes. Each compound contained either MEKO or MIBKO groups (but not both) and either a single methyl, vinyl, or phenyl group (trifunction...

journal_title：Drug and chemical toxicology

authors： Derelanko MJ,Rusch GM

更新日期：2008-01-01 00:00:00

abstract：:Three alkyl diamines, which are by-products formed and separated during the production of hexamethylene diamine, have been tested, mostly for their acute toxicity. This paper reviews methodologies used and the results obtained from these three chemicals. All three tested [2-methyl-1,5-pentanediamine (2-MP), 1,3-diamin...

journal_title：Drug and chemical toxicology

authors： Kennedy GL Jr

更新日期：2007-01-01 00:00:00

abstract：:This study assessed possible adverse immunological effects of trans-1,2-dichloroethylene (DCE) on random-bred CD-1 mice following 14 and 90 days of exposure. A 14-day range-finding study was performed on male mice by gavage at doses 1/10 and 1/100 the LD50 (210 and 21 mg/kg). No alterations in either humoral or cell-m...

journal_title：Drug and chemical toxicology

authors： Shopp GM Jr,Sanders VM,White KL Jr,Munson AE

更新日期：1985-01-01 00:00:00

abstract：:Azaperone was evaluated for its mutagenic potential by the Salmonella/microsome test. No mutagenic activity towards six S. typhimurium strains could be evidenced with azaperone at doses up to 2,000 micrograms/plate, either without or with metabolic activation at usual test conditions. Higher concentrations of liver po...

journal_title：Drug and chemical toxicology

authors： Duverger-van Bogaert M,Vanparys P,de Meester C,Marsboom R

更新日期：1987-01-01 00:00:00

abstract：:MG132, as a proteasome inhibitor, has been shown to induce apoptotic cell death through the formation of reactive oxygen species (ROS). In this study, we investigated the effects of MG132 and/or MAPK inhibitors on As4.1 juxtaglomerular cells in relation to cell growth, cell death, ROS, and glutathione (GSH) levels. MG...

journal_title：Drug and chemical toxicology

authors： Han YH,Kim SZ,Kim SH,Park WH

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Plasmodium yoelii nigeriensis (P. y. nigeriensis) produces lethal malaria infection in Swiss albino mice. Reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide along with endogenously produced tumor necrosis factor (TNF) have been implicated in the pathogenesis of malaria. OBJECTIVE:Stud...

journal_title：Drug and chemical toxicology

authors： Siddiqi NJ,Alhomida AS,Sharma B,Pandey VC

更新日期：2000-11-01 00:00:00

abstract：:The quantities of selenium, tar and nicotine present in mainstream (MS) and sidestream (SS) smoke of machine-smoked cigarettes was studied. The cigarettes were prepared from tobacco purposely cultured on fly ash-amended soil so as to increase its selenium concentration. Selenium concentration was found to be the same ...

journal_title：Drug and chemical toxicology

authors： Gutenmann WH,Lisk DJ,Shane BS,Hoffmann D,Adams JD

更新日期：1987-01-01 00:00:00

abstract：:Beagle dogs (3 to 6 years old) were treated with 100-150 mg procainamide HC1/kg/day. After 2, 5, and 9 months of treatment, peripheral blood lymphocytes were isolated and stimulated with pokeweed mitogen. The data demonstrated a suppression of mitogenesis only at 2 and 5 months after procainamide treatment. The lympho...

journal_title：Drug and chemical toxicology

authors： Mulhern SA,Daguillard F,Robinson CJ,Balazs T

更新日期：1988-06-01 00:00:00

abstract：:In view of the ability of several phosphoesterases to hydrolyze organophosphates to toxic phenols, the bioactivation of bis[p-nitrophenyl]phosphate (BNPP) by the earthworm Lumbricus terrestris was investigated. In a contact toxicity test, BNPP was was less toxic than the metabolite p-nitrophenol (PNP), but more toxic ...

journal_title：Drug and chemical toxicology

authors： Park SC,Smith TJ,Bisesi MS

更新日期：1993-01-01 00:00:00

abstract：:Chronic exposure to solar ultraviolet (UV) light induces photoaging in human skin. Our previous results have shown that areca nut procyanidins (ANPs) have antioxidant capacity and possess potential anti-inflammatory effects. Here, we aimed to investigate the effect of ANPs on UVB-induced photoaging. In the present stu...

journal_title：Drug and chemical toxicology

authors： Weng CL,Chen CC,Tsou HH,Liu TY,Wang HT

更新日期：2019-12-02 00:00:00

abstract：:In our previous reports, aspirin, an antipyretic analgesic, suppressed the genotoxicity of mitomycin C (MMC) in a somatic mutation and recombination test (SMART) in Drosophila melanogaster. In order to reveal the mechanism of the anti-genotoxicity of aspirin, we evaluated the suppressing ability of each aspirin metabo...

journal_title：Drug and chemical toxicology

authors： Niikawa M,Nakamura T,Nagase H

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:The present study was undertaken to explore the effects of monensin, a potent Golgi disturbing agent on male fertility. METHODS:Male Wistar rats were administered monensin at the dose levels of 2.5, 5, and 10 mg/kg b wt. Animals were sacrificed after 67 days of the treatment. The activities of lactate dehydr...

journal_title：Drug and chemical toxicology

authors： Singh M,Kalla NR,Sanyal SN

更新日期：2014-10-01 00:00:00

abstract：:The in vitro effect of methyl mercury (MM) and lead (Pb) on N-methyl-D-aspartate (NMDA)-specific glutamate receptor binding in neonatal (10 days old) and adult rat brain was investigated. The cerebral cortex was isolated from the neonatal and adult male Sprague-Dawley rats and the synaptic plasma membranes were prepar...

journal_title：Drug and chemical toxicology

authors： Rajanna B,Rajanna S,Hall E,Yallapragada PR

更新日期：1997-02-01 00:00:00

abstract：:Lead (Pb), a known environmental toxicant, adversely affects almost all organ systems. In this study, we investigated the effects of maternal lead exposure on fetal rat cerebellum. Female Sprague-Dawley rats were given lead nitrate in drinking water (0, 0.5, and 1%) for two weeks before conception, and during pregnanc...

journal_title：Drug and chemical toxicology

authors： Mousa AM,Al-Fadhli AS,Rao MS,Kilarkaje N

更新日期：2015-01-01 00:00:00

abstract：:Ammonium perfluoroocanoate (APFO) was repeatedly administered orally to male Crj:CD(SD)IGS rats for 14 days. Doses of APFO were 0, 0.5, 5, and 50 mg/kg. Significant increases and increasing tendencies in absolute/relative weight of the liver and no change in weight of the spleen were observed in all groups. Although i...

journal_title：Drug and chemical toxicology

authors： Iwai H,Yamashita K

更新日期：2006-01-01 00:00:00

abstract：:Organoselenium compounds can cause anemia in mice, possibly as a consequence of impairment of the heme biosynthesis pathway. Such compounds can inhibit the sulfhydryl-containing enzyme delta-aminolevulinate dehydratase (delta-ALA-D), which is involved in the heme biosynthetic pathway, leading to a decrease in the synt...

journal_title：Drug and chemical toxicology

authors： Folmer V,Farina M,Maciel EN,Nogueira CW,Zeni G,Emanuelli T,Rocha JB

更新日期：2004-11-01 00:00:00

abstract：:The purpose of this research was to evaluate the efficacy of carsil (CAR) either alone or in combination with α-tocopherol (α-TOCO) and/or turmeric (TUMR) against tetrachloromethane (TCM)-induced cardiomyocyte injury in rats. Administration of CAR either alone or in combination with α-TOCO and/or TUMR post-TCM injecti...

journal_title：Drug and chemical toxicology

authors： Alshanwani AR,Faddah LM,Hagar H,Alhusaini AM,Shaheen S,Mohammad RA,Alharbi FMB,AlHarthii A,Badr AM

更新日期：2020-10-15 00:00:00

abstract：:This paper discusses the merits and disadvantages of a specific proposal for a numerical calculation of the reference dose (RfD) with explicit recognition of both uncertainty and variability. It is suggested that the RfD be the lower (more restrictive) value of: The daily dose rate that is expected (with 95% confidenc...

journal_title：Drug and chemical toxicology

authors： Hattis D,Baird S,Goble R

更新日期：2002-11-01 00:00:00

abstract：:As a measure of glutathione (GSH) conjugation, urinary, fecal and biliary excretion of thioethers and hepatic GSH content were measured in rhesus monkeys following administration of single doses of naphthalene and diethylmaleate (DEM). Naphthalene had little or no effect on hepatic GSH content and the excretion of thi...

journal_title：Drug and chemical toxicology

authors： Rozman K,Summer KH,Rozman T,Greim H

更新日期：1982-01-01 00:00:00

abstract：:Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaco...

journal_title：Drug and chemical toxicology

authors： Ye Q,Liu H,Fang C,Liu Y,Liu X,Liu J,Zhang C,Zhang T,Peng C,Guo L

更新日期：2019-03-21 00:00:00

abstract：:Visual observations were made to compare the pretreatment benefits of subacute (75 micrograms/hr, sc) and acute (146 micrograms/kg, im, at 30 min) deliveries of physostigmine salicylate (Phy) against 2 or 5 LD50s (60 or 150 micrograms/kg, sc) of soman in guinea pigs; scopolamine, 80 micrograms/kg, im, was given routin...

journal_title：Drug and chemical toxicology

authors： Anderson DR,Harris LW,Lennox WJ,Solana RP

更新日期：1991-01-01 00:00:00

abstract：:The objective of the present study was to evaluate the oxidative stress potential of low-level organophosphate fenthion exposure with the modulatory effect of buthionine sulfoximine in the liver of Cyprinus carpio L. The fish were exposed to 20% of 96-hour LC(50) of fenthion for 24 and 96 hours. Total and oxidized glu...

journal_title：Drug and chemical toxicology

authors： Uner N,Sevgiler Y,Piner P,Durmaz H

更新日期：2008-01-01 00:00:00

abstract：:Albino mice (8-10 wks) weighing between 14 and 25 g were divided into 2 groups and dosed orally once per week with 2 doses (7 mg/kg and 21 mg/kg) of the gut-stimulating principle in Croton penduliflorus seeds (CP crystals) for 12 weeks. Some mice (3-4) from each group were killed at 10 days intervals for the first 6 w...

journal_title：Drug and chemical toxicology

authors： Asuzu IU,Shetty SN,Anika SM

更新日期：1989-03-01 00:00:00

abstract：:It is generally thought that residual unpolymerized (meth)acrylic monomers commonly found in pressure sensitive adhesive tapes for medical use may cause dermal irritation, but a systematic study has never been carried out. Therefore, we assessed the potential dermal irritating effect of residual (meth)acrylic monomers...

journal_title：Drug and chemical toxicology

authors： Tokumura F,Matsui T,Suzuki Y,Sado M,Taniguchi M,Kobayashi I,Kamiyama M,Suda S,Nakamura A,Yamazaki Y,Yamori A,Igarashi R,Kawai J,Oka K

更新日期：2010-01-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, celecoxib, and etoricoxib are reported to act as chemopreventive agents in experimental colon cancer induced by 1,2-dimethylhydrazine (DMH) as they are known cyclooxygenase (COX) enzyme inhibitors. To determine whether NSAIDs can also effectively modulate ...

journal_title：Drug and chemical toxicology

authors： Kanwar SS,Vaiphei K,Nehru B,Sanyal SN

更新日期：2007-01-01 00:00:00

abstract：:The relationship between lead concentration in the dry film of lead based paints applied to steel bulkheads aboard ship, the lead concentration found in the air when the paint is removed by mechanical means, and blood lead concentrations of workers involved in lead based paint removal has not been well characterized. ...

journal_title：Drug and chemical toxicology

authors： Alexander WK,Carpenter RL,Kimmel EC

更新日期：1999-02-01 00:00:00

abstract：:The present study was aimed to report the toxicity of the chlorpyrifos, an organophosphorus insecticide, with regard to histological and cytological effects through light and transmission electron microscopes in the gills of freshwater fish, Anabas testudineus. The fish were exposed to 0.125 (5% of 96 h LC50), 0.250 (...

journal_title：Drug and chemical toxicology

authors： Velmurugan B,Cengiz EI,Yolcu M,Uğurlu P,Selvanayagam M

更新日期：2020-07-01 00:00:00

abstract：CONTEXT:Crack cocaine is an illicit drug derived from cocaine, in which use and abuse have increased around the world, especially in developing countries. OBJECTIVES:The aim of this study was to evaluate genomic damage in multiple organs of mice following acute exposure to crack cocaine. For this purpose, single cell ...

journal_title：Drug and chemical toxicology

authors： Yujra VQ,Moretti EG,Claudio SR,Silva MJ,Oliveira Fd,Oshima CT,Ribeiro DA

更新日期：2016-10-01 00:00:00

abstract：:Gold nanorods (GNRs) are used for their wide variety of applications in various industries. There is a little availability of data related to toxicity and ecological implications of these GNRs. The study evaluated the oxidative stress induction following intra-tracheal instillation of 1 and 5 mg/kg b.w. doses of 10 an...

journal_title：Drug and chemical toxicology

authors： Lingabathula H,Yellu N

更新日期：2018-04-01 00:00:00