The effects of intratracheally-administered imipramine on the rat lung.

abstract：:As a measure of glutathione (GSH) conjugation, urinary, fecal and biliary excretion of thioethers and hepatic GSH content were measured in rhesus monkeys following administration of single doses of naphthalene and diethylmaleate (DEM). Naphthalene had little or no effect on hepatic GSH content and the excretion of thi...

journal_title：Drug and chemical toxicology

authors： Rozman K,Summer KH,Rozman T,Greim H

更新日期：1982-01-01 00:00:00

abstract：:Given the increasing prevalence of occupational sensitization to acrylate compounds, n-butyl acrylate (BAC), ethyl acrylate (EAC), and trimethylol propane triacrylate (TMT) were recommended by the National Toxicology Program for hypersensitivity testing in female B6C3F1 mice. The objectives of these studies were to de...

journal_title：Drug and chemical toxicology

authors： Hayes BB,Meade BJ

更新日期：1999-08-01 00:00:00

abstract：:Many pharmaceuticals are administered to children and adults as sprays provided in nebulizers or metered-dose inhalers. Stress associated with possible eye irritation and injury attributable to exposure to vapors and particulates during the required safety testing procedures of such medicines is a potential confoundin...

journal_title：Drug and chemical toxicology

authors： Rothenberg SJ,Martin MM,Sherer KI,Parker RM,Dearlove GE,Christian MS

更新日期：1998-08-01 00:00:00

abstract：:A 1-year chronic toxicity study was conducted in which rhesus monkeys (4/sex/dose) were given daily doses of 0, 3, 10, or 25 mg zatosetron/kg by nasogastric intubation. Clinical signs of toxicity characterized by salivation, diarrhea or soft stools, and/or emesis occurred in animals that received 10 or 25 mg/kg of zat...

journal_title：Drug and chemical toxicology

authors： Bendele A,Means J,Shoufler J,Schmalz C,Hanasono G,Symanowski J,Adams E

更新日期：1995-02-01 00:00:00

abstract：:Neurodegenerative diseases affect millions of people. Major reasons behind the onset and progression of these diseases are still under investigation. Therefore, any approach that would treat/prevent progression is important. In this study, we aimed to investigate the potential protective effects of Psephellus pyrrhobl...

journal_title：Drug and chemical toxicology

authors： Taştan P,Armagan G,Dağcı T,Kıvçak B

更新日期：2019-09-02 00:00:00

abstract：:The Salmonella typhimurium/microsome assay is a widely used bacterial genotoxicity assay to test potential carcinogens. The aim of this work was to evaluate the mutagenic and antimutagenic activities with and without the addition of an extrinsic metabolic activation system of essential oils obtained from an aerial par...

journal_title：Drug and chemical toxicology

authors： Neffati A,Limem I,Kilani S,Bouhlel I,Skandrani I,Bhouri W,Ben Sghaier M,Boubaker J,Ledauphin J,Barillier D,Ghedira LC,Ghedira K

更新日期：2009-01-01 00:00:00

abstract：:Nephrotoxicity is a major limitation of adriamycin (ADR) chemotherapy. We hypothesized that administration of standardized aqueous bark extract of Gmelina arborea Roxb. (GA) (Family; Verbenaceae), a traditional therapeutic agent, may reduce the nephrotoxicity caused by ADR in Wistar rats. The dose-dependent nephroprot...

journal_title：Drug and chemical toxicology

authors： Amarasiri SS,Attanayake AP,Arawwawala LDAM,Jayatilaka KAPW,Mudduwa LKB

更新日期：2020-08-30 00:00:00

abstract：:Modafinil is used for the treatment of various sleep disorders; however, its usage among healthy individuals is also increasing. There are a limited number of cardiovascular side effects, including ischemic T-wave changes, dyspnea, hypertension, and tachycardia in the literature. Our research aimed to investigate the ...

journal_title：Drug and chemical toxicology

authors： Canyurt D,Tanriverdi LH,Ozhan O,Cansel M,Parlakpinar H,Vardi N,Cigremis Y,Yildiz A,Karaca Y,Yasar S,Acet A

更新日期：2020-08-11 00:00:00

abstract：:Many steps are required to convert a normal cell into a cancerous one. The cancer cell must be able to multiply under conditions that a normal cell would not and to invade surrounding tissue and spread throughout the body. Both genetic changes, such as activation of oncogenes or inactivation of tumor suppressor genes,...

journal_title：Drug and chemical toxicology

authors： Couch DB

更新日期：1996-08-01 00:00:00

abstract：:The in vitro effect of methyl mercury (MM) and lead (Pb) on N-methyl-D-aspartate (NMDA)-specific glutamate receptor binding in neonatal (10 days old) and adult rat brain was investigated. The cerebral cortex was isolated from the neonatal and adult male Sprague-Dawley rats and the synaptic plasma membranes were prepar...

journal_title：Drug and chemical toxicology

authors： Rajanna B,Rajanna S,Hall E,Yallapragada PR

更新日期：1997-02-01 00:00:00

abstract：:This study was designed to test the pulmonary tumor response to intratracheally instilled silica in Strain A mice. Urethane was used as a positive control. Silica treatment was utilized to evaluate the effect of a potent fibrinogen on pulmonary adenoma formation in this unique animal model. Urethane produced an increa...

journal_title：Drug and chemical toxicology

authors： McNeill DA,Chrisp CE,Fisher GL

更新日期：1990-01-01 00:00:00

abstract：:The purpose of this study was to assess the compatibility, in terms of red blood cell acetylcholinesterase (AChE) inhibition, of ondansetron (OND; a 5-hydroxytryptamine subtype-3 receptor antagonist) with the organophosphorus pretreatment compound pyridostigmine (PYR) after simultaneous oral (p.o.) administration to g...

journal_title：Drug and chemical toxicology

authors： Capacio BR,Byers CE,Anderson DR,Matthews RL,Brown DE

更新日期：1996-01-01 00:00:00

abstract：:Methyl 2,2-difluoromalonyl fluoride (MMF) is highly toxic by inhalation producing mortality in rats exposed for 4 hours to 0.55 mg/L. Repeated inhalation exposures of rats to 0.009 mg/L produced irritation but no other signs of a toxic response. Mortality was encountered following repeated exposures to 0.066 mg/L. ...

journal_title：Drug and chemical toxicology

authors： Kennedy GL Jr,Burgess BA,Chen HC

更新日期：1988-06-01 00:00:00

abstract：:The objective of this study was to evaluate the residues of 42 pesticides subject to public concern in Tieguanyin tea produced in Fujian, China. The presence of 42 pesticide residues in 90 Tieguanyin tea samples were determined. A total of 17 pesticides were detected. At least one pesticide residue was detected in 65 ...

journal_title：Drug and chemical toxicology

authors： Yao Q,Yan SA,Li J,Huang M,Lin Q

更新日期：2020-08-04 00:00:00

abstract：:The median lethal dose (LD50) of chymopapain B in mice was 82 mg/kg (22,000 units/kg) with 95% confidence limits of 75-90 mg/kg (20, 122-24, 146 units/kg) and in rats 92 (24,683 units/kg) with 95% confidence limits of 83-102 mg/kg (22,268-27, 366 units/kg). The mechanism of toxicity was hemorrhage due to destruction o...

journal_title：Drug and chemical toxicology

authors： Simmons JW,Upman PJ,Stavinoha WB

更新日期：1984-01-01 00:00:00

abstract：:In view of the ability of several phosphoesterases to hydrolyze organophosphates to toxic phenols, the bioactivation of bis[p-nitrophenyl]phosphate (BNPP) by the earthworm Lumbricus terrestris was investigated. In a contact toxicity test, BNPP was was less toxic than the metabolite p-nitrophenol (PNP), but more toxic ...

journal_title：Drug and chemical toxicology

authors： Park SC,Smith TJ,Bisesi MS

更新日期：1993-01-01 00:00:00

abstract：:Suppression of mitogen-induced splenocyte lymphoproliferation and interleukin 2 (IL-2) production can be used as indicators of immunotoxicity. Staphylococcal enterotoxin A (SEA) is both a potent mitogen and the most potent in vitro inducer of IL-2 production that has been described. An in vitro system was used to meas...

journal_title：Drug and chemical toxicology

authors： Reid LL,Hastings KL,Gandolfi AJ,Van Ert M

更新日期：1994-01-01 00:00:00

abstract：:Prolonged exposure to aluminum through occupational hazards or food/water intake has been linked to the occurrence of Alzheimer's disease (AD). This study aimed at investigating the neuroprotective effects of Gallic Acid (GA) against aluminum-chloride induced AD in adult Wistar rats. Twenty eight (28) adult Wistar rat...

journal_title：Drug and chemical toxicology

authors： Ogunlade B,Adelakun SA,Agie JA

更新日期：2020-04-24 00:00:00

abstract：:The toxicity of etephon and maleic hydrazide, used as plant growth regulators in agriculture, were reported as low in mammals in previous studies. However, in vitro cytotoxicity studies in mammalian cells are currently missing to understand their toxicity at molecular level. In the current study, the cytotoxicity of t...

journal_title：Drug and chemical toxicology

authors： Yurdakok B,Baydan E,Okur H,Gurcan IS

更新日期：2014-10-01 00:00:00

abstract：CONTEXT:Withania somnifera (L) Dunal (Solanaceae) is an important traditional herbal medicine used for thousands of years and is considered as the Indian ginseng. Reports on the effect of Withania somnifera root (WSR) extract on the developing foetus of pregnant rats including mortality, structural abnormalities, chang...

journal_title：Drug and chemical toxicology

authors： Prabu PC,Panchapakesan S

更新日期：2015-01-01 00:00:00

abstract：:The genotoxic effect of CBZ has been investigated in few studies. There is little evidence linking carbamazepine (CBZ) with any genotoxic effects, particularly in vitro micronucleus test using cytogenesis-block technique. In this study, the genotoxicity of the antiepileptic drug, carbamazepine, was tested using cytoki...

journal_title：Drug and chemical toxicology

authors： Celik A

更新日期：2006-01-01 00:00:00

abstract：:Orlistat is an FDA-approved over-the-counter drug to treat obesity through the inhibition of lipase activity. Macrophages, which express high levels of lipoprotein lipase (LPL), are important phagocytes in the innate immune system. Our previous studies indicated that environmentally relevant concentrations of arsenite...

journal_title：Drug and chemical toxicology

authors： Lou K,Huang P,Ma H,Wang X,Xu H,Wang W

更新日期：2019-10-31 00:00:00

abstract：:In the subchronic study acrylic acid was incorporated in the drinking water of Fischer 344 rats (15 per group) for three months at dosage levels of 0.75, 0.25, 0.083 or 0 g/kg/day. No deaths occurred during the study but several treatment-related effects were observed. At 0.75 g/kg/day dosage level, body weight gain w...

journal_title：Drug and chemical toxicology

authors： DePass LR,Woodside MD,Garman RH,Weil CS

更新日期：1983-01-01 00:00:00

abstract：:An automatic system was developed to monitor continuously the colonic temperature of laboratory animals during inhalation exposure to toxic chemicals. It includes: an automatic switchbox, a control circuit, a recorder and a digital voltmeter. The system was calibrated for different temperature ranges and used for a ye...

journal_title：Drug and chemical toxicology

authors： Laham S,Schrader K,Symonds G,Curtin W

更新日期：1978-01-01 00:00:00

abstract：:1-((2-methyl-4-[(2-methyl phenyl)azo] phenyl)azo)-2-naphthalenol (C.I. Solvent Red 24) was prepared having a 14C label on the methyl group of the central ring and was administered in suspension intra-tracheally to a male and a female rat. After 96 hours in metabolism cages, the animals were sacrificed and 14C counted ...

journal_title：Drug and chemical toxicology

authors： Parent RA,Dressler I

更新日期：1979-01-01 00:00:00

abstract：:The potential maternal and developmental toxicity of cyclododecatriene (CDDT) was assessed in rats. Groups of 22 time-mated female Crl:CD (SD) BR rats were exposed by inhalation (whole-body, 6 h/day) to either 0 (control), 10, 25, or 67 ppm CDDT over days 6-20 of gestation (days 6-20 G); the day of copulation plug det...

journal_title：Drug and chemical toxicology

authors： Munley SM,Kelly DP,Kennedy GL Jr

更新日期：2003-08-01 00:00:00

abstract：:In the present study, coffee (CF) was evaluated for its protective effects against genotoxic damage and oxidative stress induced by the chemotherapeutic drug, cyclophosphamide (CPH). The sex-linked recessive lethal (SLRL) test was employed to study the induction of mutations in the larvae as well as in all the success...

journal_title：Drug and chemical toxicology

authors： Nagpal I,Abraham SK

更新日期：2019-09-01 00:00:00

abstract：:This Visual Basic computer program has been developed for drug dosage conversions using metabolically active mass (MAM) of the animals. The two body weights (one with known dosage and the other, for which the dosage has to be calculated) and the known dosage are entered in the respective input boxes and the appropriat...

journal_title：Drug and chemical toxicology

authors： Khan HA

更新日期：2003-02-01 00:00:00

abstract：:In this study, we investigated the effect of vernolide-A on the induction of apoptosis as well as its regulatory effect on the activation of transcription factors in B16F-10 melanoma cells. Treatment of B16F-10 cells with nontoxic concentrations of vernolide-A showed the presence of apoptotic bodies and induced DNA fr...

journal_title：Drug and chemical toxicology

authors： Pratheeshkumar P,Kuttan G

更新日期：2011-07-01 00:00:00

abstract：:Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaco...

journal_title：Drug and chemical toxicology

authors： Ye Q,Liu H,Fang C,Liu Y,Liu X,Liu J,Zhang C,Zhang T,Peng C,Guo L

更新日期：2019-03-21 00:00:00