Abstract:
:A comparison of the fertility and cytogenetic analyses and the combination of both techniques as generally used in the heritable translocation assay was conducted with triethylenemelamine (TEM). CD-1 mice were used as the F0 generation and were divided into two groups that received i.p. either distilled water (control) or TEM at 0.15-0.20 mg/kg. A total of 226 F1 males were generated (125 control, 101 TEM group) and were subjected to both sequential fertility assessment and direct cytogenetic analysis. A litter size of 10 was used for the fertility assessment method and 25 cells per animal were scored for the direct cytogenetic analysis; 20 animals were initially identified as translocation carriers based on the fertility analysis and 16 animals were identified by cytogenetic analysis. When these data were compared and the discrepancies resolved, each method separately identified 16 translocation carriers (15 animals common to both methods). With the combination of data for both techniques, as is done in the heritable translocation assay, a total of 17 translocation heterozygotes were identified. Use of either the fertility method alone or the cytogenetic method as routinely used would have resulted in the separate identification of 16 translocation carriers per procedure, with each method failing to identify one carrier.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Moreland FM,Sheu CJdoi
10.3109/01480548309017808subject
Has Abstractpub_date
1983-01-01 00:00:00pages
537-48issue
6eissn
0148-0545issn
1525-6014journal_volume
6pub_type
杂志文章abstract::Adverse reactions induced by Chinese herbal injections have been frequently reported. However, the precise causes of these adverse reactions are not yet fully understood. The aim of the present study was to determine the role of chlorogenic acid (a ubiquitous component of Chinese herbs) in the toxicity of Chinese herb...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480540903580055
更新日期:2010-10-01 00:00:00
abstract::The effect of chlormethiazole (CMZ) at single and multiple doses on the toxicokinetics of diethylnitrosamine (DEN) was investigated in normal rats and those with DEN-induced liver fibrosis. Twelve rats were treated with DEN (50 mg/kg) alone and in combination with a single dose of CMZ (10, 50, or 100 mg/kg) by intrape...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1455204
更新日期:2019-11-01 00:00:00
abstract::The 24-h incorporation of 59Fe into circulating red blood cells, bone marrow, urine, liver, spleen, and skeletal muscle was measured in splenectomized and sham-splenectomized rats which had received a daily, oral dose of gossypol acetic acid (20 mg GAA/kg body wt) for 91 days. A significant decrease in total body weig...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548509011635
更新日期:1985-01-01 00:00:00
abstract::The object of this study was to evaluate the toxicity of norbornene fluoroalcohol (NBFOH), which is used as an intermediate in the production of fluorinated monomers and polymers. NBFOH was evaluated for acute oral, dermal, and inhalation toxicity, dermal sensitization using the Local Lymph Node Assay (LLNA), mutagene...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540500262680
更新日期:2005-01-01 00:00:00
abstract::Methyl 2,2-difluoromalonyl fluoride (MMF) is highly toxic by inhalation producing mortality in rats exposed for 4 hours to 0.55 mg/L. Repeated inhalation exposures of rats to 0.009 mg/L produced irritation but no other signs of a toxic response. Mortality was encountered following repeated exposures to 0.066 mg/L. ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548808998223
更新日期:1988-06-01 00:00:00
abstract::We designed this study to identify the factors associated with time to successful weaning in mechanically ventilated organophosphate (OP)-poisoned patients as the primary outcomes while duration of mechanical ventilation (MV) support, intensive care unit (ICU), and hospital length of stay (LOS) and in-hospital mortali...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1870487
更新日期:2021-01-12 00:00:00
abstract::The availability of tissue glutathione (GSH) appears to depend upon a balance between tissue concentrations, the rate of reactive metabolite formation and the re-synthesis of GSH. To test this hypothesis, diethyl maleate (DEM, 5.8 mmol/kg bw) was administered intraperitoneally to male and female mice, hamsters, rats a...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548408998263
更新日期:1984-01-01 00:00:00
abstract::The cytotoxic effect of caffeine on heart cells was evaluated in primary cultures of rat heart muscle (M) and endothelioid (E) cells. The cultures were exposed to 5, 10, or 20 mM caffeine for 6, 12, or 24 hours. As an index of cytotoxicity produced by the treatments, in situ changes in mitochondrial membrane fragility...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480547709034424
更新日期:1977-01-01 00:00:00
abstract::The role of oxidative-stress as a mechanism of hepatotoxicity caused by combination of isoniazid (INH) and Rifampicin (RMP) was investigated in young growing rats. A successful model of hepatotoxicity was produced by giving 50 mg/kg/day each of INH and RMP in two weeks. Liver showed type II hepatocellular changes (mic...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549709003881
更新日期:1997-08-01 00:00:00
abstract::2-Amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine (ACCPE) is a water soluble compound formed during the alkaline treatment of the alcoholic liquor in the production of 2-chlorobenzylidene malononitrile (CS). The acute toxicity and primary irritancy of ACCPE and CS were investigated and compared. Both perorally and...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548508999168
更新日期:1985-01-01 00:00:00
abstract::In this study, the effects of a neonicotinoid insecticide acetamiprid on the sciatic nerve of Rana ridibunda were investigated by using electrophysiological and histological methods. A total of 35 preparations of sciatic nerve isolated from 35 frogs (Nervus ischiadicus) were used in the experiments. Experiments were d...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1442475
更新日期:2019-05-01 00:00:00
abstract::Gold nanorods (GNRs) are used for their wide variety of applications in various industries. There is a little availability of data related to toxicity and ecological implications of these GNRs. The study evaluated the oxidative stress induction following intra-tracheal instillation of 1 and 5 mg/kg b.w. doses of 10 an...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2017.1321012
更新日期:2018-04-01 00:00:00
abstract::A series of new compounds were evaluated for acute in vivo toxicity. Their synthesis and antifungal activity have previously been described by us. The naturally occurring class of compounds to which they belong - the benzylidenechroman-4-ones - have been identified as a potential source of new antifungal agents. These...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549009018120
更新日期:1990-01-01 00:00:00
abstract::Male Sprague-Dawley rats were administered cadmium chloride 0, 50, 100, 150 and 200 ppm for 30 days. At the end of the treatments, the body weight gains, serum glucose, serum protein, serum glutamic oxalacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were determined. Renal and hepatic key glu...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548009030129
更新日期:1980-01-01 00:00:00
abstract::Chemical pretreatment is effective against a 2 LD50 challenge of soman, sarin or VX or a 5 LD50 challenge of tabun. Chemical pretreatment followed by post challenge therapy should be effective against greater levels of agent. Such tests in guinea pigs are reported here; pretreatment regimens (PRGs) consisted of physos...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549209014157
更新日期:1992-01-01 00:00:00
abstract::The toxicity of etephon and maleic hydrazide, used as plant growth regulators in agriculture, were reported as low in mammals in previous studies. However, in vitro cytotoxicity studies in mammalian cells are currently missing to understand their toxicity at molecular level. In the current study, the cytotoxicity of t...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2014.884112
更新日期:2014-10-01 00:00:00
abstract::A Type II pyrethroid pesticide β-cypermethrin is widely used in agriculture and domestic applications for pest control. However, the effect of β-cypermethrin on the glutamate neurotransmitter has not been well-documented. In the current study, mice were treated with 20, 40, or 80 mg/kg β-cypermethrin by a single oral ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2014.900072
更新日期:2015-01-01 00:00:00
abstract::Exposure to crude acetylene can occur in occupational settings. This study assessed the modulatory activities of selected polyphenols on the hematotoxic, cardiotoxic, and hepatotoxic effects of crude acetylene. Wistar rats were exposed to 58 000 ppm crude acetylene for 10 min at 12 h intervals for 30 days. Some expose...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1853766
更新日期:2020-12-08 00:00:00
abstract::This study was conducted to evaluate the potential reproductive toxicity of epichlorohydrin in a one-generation reproduction toxicity study in compliance with OECD Test Guideline 415. Twenty-four male and female rats per group were given epichlorohydrin by gavage at 0, 3.3, 10, and 30 mg/kg/day. Males were dosed for 1...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480541003734030
更新日期:2010-07-01 00:00:00
abstract::Toxic fungal metabolites - mycotoxins - cause poisonings after consumption of contaminated food commodities. The most probable intoxications are connected with eating poorly stored food or inhaling of moldy dust. One of the effective ways to protect people against mycotoxins is timely detection. Several methods such a...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章,评审
doi:10.1080/01480540701375232
更新日期:2007-01-01 00:00:00
abstract::Acute and repeated oral and dermal rat toxicology studies of standard designs were conducted on four methyl ethyl ketoxime (MEKO) silanes and four methyl isobutyl ketoxime (MIBKO) silanes. Each compound contained either MEKO or MIBKO groups (but not both) and either a single methyl, vinyl, or phenyl group (trifunction...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540701688766
更新日期:2008-01-01 00:00:00
abstract::Cisplatin-induced nephrotoxicity is closely associated with an increase in lipid peroxidation. In several previous reports it was claimed that acetylsalicylic acid (ASA) shows its therapeutic potential as a free radical scavenger. The aim of the study was to investigate effects of ASA on cisplatin induced nephrotoxici...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-120024841
更新日期:2003-11-01 00:00:00
abstract::In this study, the hepatoprotective activity of methanol bark extract of Alangium salviifolium (BEA) was evaluated for biochemical and histological parameters in swiss albino mice with CCl4-induced hepatotoxicity. The hepatomodulatory effect of two doses of BEA (20 and 50 mg/kg bw for 15 days by oral gavage) was asses...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1733593
更新日期:2020-03-06 00:00:00
abstract::Polypeptide antibiotics, such as polymyxins and aminoglycosides, are essential for treatment of life-threatening Gram-negative infections. Acute kidney injury (AKI) attributed to treatment with these agents severely limits their clinical application. Because standard biomarkers (serum creatinine [sCRE] and blood urea ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2013.834360
更新日期:2014-04-01 00:00:00
abstract::Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaco...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1586916
更新日期:2019-03-21 00:00:00
abstract::Modafinil is used for the treatment of various sleep disorders; however, its usage among healthy individuals is also increasing. There are a limited number of cardiovascular side effects, including ischemic T-wave changes, dyspnea, hypertension, and tachycardia in the literature. Our research aimed to investigate the ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1803906
更新日期:2020-08-11 00:00:00
abstract::Currently, no standardized and well-validated alternative models exist for screening for progesterone-responsive endocrine disrupting chemicals (EDCs). Because of this, a rapid assay for evaluating progestin/antiprogestin activity using Xenopus oocyte germinal vesicle breakdown (GVBD) as a model was evaluated. Five co...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-120005892
更新日期:2002-08-01 00:00:00
abstract::An automatic system was developed to monitor continuously the colonic temperature of laboratory animals during inhalation exposure to toxic chemicals. It includes: an automatic switchbox, a control circuit, a recorder and a digital voltmeter. The system was calibrated for different temperature ranges and used for a ye...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480547809105018
更新日期:1978-01-01 00:00:00
abstract::Dicyclohexylcarbodiimide (DCC) and diisopropylcarbodiimide (DIC) are two commonly used coupling reagents in protein synthesis resulting in exposure of individuals in chemical and pharmaceutical industries as well as research laboratories involved in protein synthesis and recombinant DNA techniques. The objectives of t...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549809011647
更新日期:1998-05-01 00:00:00
abstract::Various chemical groups were evaluated for their skin sensitization potential in the guinea pig. In general, amines, acetanilides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further structural-related correlations or predictions sh...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548109017825
更新日期:1981-01-01 00:00:00