Abstract:
:Adult male Sprague Dawley rats were gavaged with 2,4-dinitrotoluene (2,4-DNT) dissolved in corn oil at 0, 60, 180, or 240 mg/kg/day for five days. A single oral dose (0.5 mg/kg) of triethylenemelamine was used as a positive control. Induction of dominant lethal events was scored on the basis of early fetal deaths. At the two lower doses, no consistent changes were observed in the numbers of pre-implantation losses, implantation sites, or living or non-living fetuses. The highest dose of 2,4-DNT tested resulted in a marked decrease in the numbers of sperm-positive females (determined by microscopic examination of vaginal smears for sperm) and pregnant females. These two effects diminished in the latter weeks of mating. The low number of pregnant females at the highest dose made meaningful statistical evaluations difficult. The results indicate that 2,4-DNT does not cause dominant lethal mutations but does adversely affect reproductive performance.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Lane RW,Simon GS,Dougherty RW,Egle JL Jr,Borzelleca JFdoi
10.3109/01480548509038650subject
Has Abstractpub_date
1985-01-01 00:00:00pages
265-80issue
4eissn
0148-0545issn
1525-6014journal_volume
8pub_type
杂志文章abstract::In the subchronic study acrylic acid was incorporated in the drinking water of Fischer 344 rats (15 per group) for three months at dosage levels of 0.75, 0.25, 0.083 or 0 g/kg/day. No deaths occurred during the study but several treatment-related effects were observed. At 0.75 g/kg/day dosage level, body weight gain w...
journal_title:Drug and chemical toxicology
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doi:10.3109/01480548309072459
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章,评审
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journal_title:Drug and chemical toxicology
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doi:10.3109/01480549009018120
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journal_title:Drug and chemical toxicology
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更新日期:1982-01-01 00:00:00
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journal_title:Drug and chemical toxicology
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doi:10.3109/01480548408998263
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journal_title:Drug and chemical toxicology
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更新日期:1994-01-01 00:00:00
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journal_title:Drug and chemical toxicology
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abstract::Antioxidant activity of Acacia salicina extracts was determined by the ability of each extract to inhibit lipid peroxidation, to protect against DNA strand scission induced by hydroxyl radicals, and to scavenge the free radical, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(*+)). The IC(50) values of t...
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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更新日期:1978-01-01 00:00:00
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
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abstract::Endophytic fungi are promising sources of bioactive substances; however, their secondary metabolites are toxic to plants, animals, and humans. This study aimed toevaluate the toxic, cytotoxic, mutagenic and oxidant/antioxidant activities of acetonitrile extract (AEPc), citrinin (CIT) and dicitrinin-A (DIC-A) of Penici...
journal_title:Drug and chemical toxicology
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