abstract：:Embryonic mammary gland development involves the formation of mammary placodes, invagination of flask-shaped mammary buds and development of miniature bi-layered ductal trees. Currently there is a good understanding of the factors that contribute to ectodermal cell movements to create these appendages and of pathways ...

journal_title：Seminars in cell & developmental biology

authors： Spina E,Cowin P

更新日期：2021-01-17 00:00:00

abstract：:The sympathetic nervous system represents a critical mechanism for homoeostatic blood pressure regulation in humans. This review focuses on age-related alterations in neurocirculatory regulation in men and women by highlighting human studies that examined the relationship between muscle sympathetic nerve activity (MSN...

journal_title：Seminars in cell & developmental biology

authors： Klassen SA,Joyner MJ,Baker SE

更新日期：2021-01-16 00:00:00

abstract：:Aluminium salts have been used as adjuvants in vaccines for almost a century, but still no clear understanding of the mechanisms behind the immune stimulating properties of aluminium based adjuvants is recognized. Aluminium adjuvants consist of aggregates and upon administration of a vaccine, the aggregates will be re...

journal_title：Seminars in cell & developmental biology

authors： Danielsson R,Eriksson H

更新日期：2021-01-07 00:00:00

abstract：:Demyelinating disorders of the central white matter are among the most prevalent and disabling conditions in neurology. Since myelin-producing oligodendrocytes comprise the principal cell type deficient or lost in these conditions, their replacement by new cells generated from transplanted bipotential oligodendrocyte-...

journal_title：Seminars in cell & developmental biology

authors： Goldman SA,Mariani JN,Madsen PM

更新日期：2021-01-04 00:00:00

abstract：:The capacity of cells and animals to sense and adapt to fluctuations in the availability of energetic substrates is commonly described as metabolic flexibility. This flexibility allows for example the transition from fed to fasting states and to meet the energy demands of exercise in both states. Flexibility is disrup...

journal_title：Seminars in cell & developmental biology

authors： Bosch M,Parton RG,Pol A

更新日期：2020-12-01 00:00:00

abstract：:Plant oils represent an energy-rich and carbon-dense group of hydrophobic compounds. These oils are not only of economic interest, but also play important, fundamental roles in plant and algal growth and development. The subcellular storage compartments of plant lipids, referred to as lipid droplets (LDs), have long b...

journal_title：Seminars in cell & developmental biology

authors： Ischebeck T,Krawczyk HE,Mullen RT,Dyer JM,Chapman KD

更新日期：2020-12-01 00:00:00

abstract：:Lipid droplets (LDs) are versatile organelles with central roles in lipid and energy metabolism in all eukaryotes. They primarily buffer excess fatty acids by storing them as neutral lipids, mainly triglycerides and steryl esters. The neutral lipids form a core, surrounded by a unique phospholipid monolayer coated wit...

journal_title：Seminars in cell & developmental biology

authors： Renne MF,Klug YA,Carvalho P

更新日期：2020-12-01 00:00:00

abstract：:Multiple myeloma is a bone marrow neoplasia with an incidence of 6/100,000/year in Europe. While the disease remains incurable, the development of novel treatments such as autologous stem cell transplantation, proteasome inhibitors and monoclonal antibodies has led to an increasing subset of patients living with long-...

journal_title：Seminars in cell & developmental biology

authors： Diaz-delCastillo M,Chantry AD,Lawson MA,Heegaard AM

更新日期：2020-11-03 00:00:00

abstract：:The mechanistic (or mammalian) Target of Rapamycin Complex 1 (mTORC1) is a central regulator of cell growth and metabolism. By integrating mitogenic signals, mTORC1-dependent phosphorylation of substrates dictates the balance between anabolic, pro-growth and catabolic, recycling processes in the cell. The discovery th...

journal_title：Seminars in cell & developmental biology

authors： Carroll B

更新日期：2020-11-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a neurological condition which affects a large number of individuals worldwide, across all ages. It can lead to major physical, cognitive and psychological impairment, and represents a considerable health cost burden. TBI is a heterogeneous condition and there has been intense effort ov...

journal_title：Seminars in cell & developmental biology

authors： Nessel I,Michael-Titus AT

更新日期：2020-10-06 00:00:00

abstract：:The family Cichlidae contains approximately 2000 species that live in diverse freshwater habitats including murky lakes, turbid rivers, and clear lakes from both the Old and New Worlds. Their visual systems are similarly diverse and have evolved specific sensitivities that differ along several axes of variation. Varia...

journal_title：Seminars in cell & developmental biology

authors： Carleton KL,Yourick MR

更新日期：2020-10-01 00:00:00

abstract：:From the mid-19th century until the 1980's, frogs and toads provided important research models for many fundamental questions in visual neuroscience. In the present century, they have been largely neglected. Yet they are animals with highly developed vision, a complex retina built on the basic vertebrate plan, an acce...

journal_title：Seminars in cell & developmental biology

authors： Donner K,Yovanovich CAM

更新日期：2020-10-01 00:00:00

abstract：:As the primary catalyst of homologous recombination (HR) in vertebrates, RAD51 has been extensively studied in the context of repair of double-stranded DNA breaks (DSBs). With recent advances in the understanding of RAD51 function extending beyond DSBs, the importance of RAD51 throughout DNA metabolism has become incr...

journal_title：Seminars in cell & developmental biology

authors： Wassing IE,Esashi F

更新日期：2020-09-13 00:00:00

abstract：:TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation. TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become ...

journal_title：Seminars in cell & developmental biology

authors： Bagge J,Oestergaard VH,Lisby M

更新日期：2020-09-07 00:00:00

abstract：:Over two decades, γ-secretase has been the target for extensive therapeutic development due to its pivotal role in pathogenesis of Alzheimer's disease and cancer. However, it has proven to be a challenging task owing to its large set of substrates and our limited understanding of the enzyme's structural and mechanisti...

journal_title：Seminars in cell & developmental biology

authors： Nie P,Vartak A,Li YM

更新日期：2020-09-01 00:00:00

abstract：:Carotenoids are an important source of metabolites with regulatory function, which include the plant hormones abscisic acid (ABA) and strigolactones (SLs), and several recently identified growth regulators and signaling molecules. These carotenoid-derivatives originate from oxidative breakdown of double bonds in the c...

journal_title：Seminars in cell & developmental biology

authors： Wang JY,Lin PY,Al-Babili S

更新日期：2020-07-27 00:00:00

abstract：:Until the discovery of human embryonic stem cells and human induced pluripotent stem cells, biotechnology companies were severely limited in the number of human tissues that they could model in large-scale in vitro studies. Until this point, companies have been limited to immortalized cancer lines or a small number of...

journal_title：Seminars in cell & developmental biology

authors： Salick MR,Lubeck E,Riesselman A,Kaykas A

更新日期：2020-07-09 00:00:00

abstract：:β cells uniquely produce and secrete insulin under the control of several, integrated signals, to maintain blood glucose concentrations within a narrow physiological interval. β cell failure is key to the onset and progression of type 2 diabetes, due to impaired function and reduced mass. In this review we focus on se...

journal_title：Seminars in cell & developmental biology

authors： Marchetti P,Suleiman M,De Luca C,Baronti W,Bosi E,Tesi M,Marselli L

更新日期：2020-07-01 00:00:00

abstract：:Cardiac chamber walls contain large numbers of non-contractile interstitial cells, including fibroblasts, endothelial cells, pericytes and significant populations of blood lineage-derived cells. Blood cells first colonize heart tissues a few days before birth, although their recruitment from the bloodstream to the car...

journal_title：Seminars in cell & developmental biology

authors： Sampaio-Pinto V,Ruiz-Villalba A,Nascimento DS,Pérez-Pomares JM

更新日期：2020-06-23 00:00:00

abstract：:Vascular plants, unlike bryophytes, have a strong root-shoot dichotomy in which the tissue systems are mutually interdependent; roots are completely dependent on shoots for photosynthetic sugars, and shoots are completely dependent on roots for water and mineral nutrients. Long-distance communication between shoot and...

journal_title：Seminars in cell & developmental biology

authors： Wheeldon CD,Bennett T

更新日期：2020-06-20 00:00:00

abstract：:The Nonsense-mediated mRNA Decay (NMD) pathway is an RNA quality control pathway conserved among eukaryotic cells. While historically thought to predominantly recognize transcripts with premature termination codons, it is now known that the NMD pathway plays a variety of roles, from homeostatic events to control of vi...

journal_title：Seminars in cell & developmental biology

authors： Leon K,Ott M

更新日期：2020-06-15 00:00:00

abstract：:For over a decade, studies of messenger RNA regulation have revealed an unprecedented level of connectivity between the RNA pool and global gene expression. These connections are underpinned by a vast array of RNA elements that coordinate RNA-protein and RNA-RNA interactions, each directing mRNA fate from transcriptio...

journal_title：Seminars in cell & developmental biology

authors： Rodriguez W,Macveigh-Fierro D,Miles J,Muller M

更新日期：2020-06-07 00:00:00

abstract：:Actin filaments (F-actin) are a key component of eukaryotic cells. Whether serving as a scaffold for myosin or using their polymerization to push onto cellular components, their function is always related to force generation. To control and fine-tune force production, cells have a large array of actin-binding proteins...

journal_title：Seminars in cell & developmental biology

authors： Merino F,Pospich S,Raunser S

更新日期：2020-06-01 00:00:00

abstract：:The vertebrate brain is organized, from its embryonic origin and throughout adult life, around a dynamic and complex fluid, the cerebrospinal fluid (CSF). There is growing interest in the composition, dynamics and function of the CSF in brain development research. It has been demonstrated in higher vertebrates that CS...

journal_title：Seminars in cell & developmental biology

authors： Bueno D,Parvas M,Nabiuni M,Miyan J

更新日期：2020-06-01 00:00:00

abstract：:Polycystic kidney disease (PKD), comprising autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD), is characterized by incessant cyst formation in the kidney and liver. ADPKD and ARPKD represent the leading genetic causes of renal disease in adults and children,...

journal_title：Seminars in cell & developmental biology

authors： Ma M

更新日期：2020-05-28 00:00:00

abstract：:CLEs are small non-cell autonomous signalling peptides that regulate cell division rate and orientation in a variety of developmental contexts. Recent years have generated a huge amount of research on CLE function across land plants, characterising their role across the whole plant; they control stem cell division in ...

journal_title：Seminars in cell & developmental biology

authors： Whitewoods CD

更新日期：2020-05-20 00:00:00

abstract：:Autophagy, an evolutional conserved lysosomal degradation process, has been implicated to play an important role in cellular defense against a variety of microbial infection. Interestingly, numerous studies found that some pathogens, especially positive-single-strand RNA viruses, actually hijacked autophagy machinery ...

journal_title：Seminars in cell & developmental biology

authors： Huang L,Yue J

更新日期：2020-05-01 00:00:00

abstract：:Autophagy is an essential and conserved cellular degradation pathway in eukaryotes. In metazoans, autophagy is highly engaged during the immune responses through interfacing either directly with intracellular pathogens or indirectly with immune signaling molecules. Recent studies have demonstrated that autophagy plays...

journal_title：Seminars in cell & developmental biology

authors： Ismayil A,Yang M,Liu Y

更新日期：2020-05-01 00:00:00

abstract：:Lamellipodial locomotion of fish keratocytes is one of the simplest examples of actin-based motility. In the last four decades, fruitful collaborations between experimentalists and theorists have resulted in a detailed mechanistic understanding of the self-organized lamellipodial engine powering keratocyte motility. H...

journal_title：Seminars in cell & developmental biology

authors： Mogilner A,Barnhart EL,Keren K

更新日期：2020-04-01 00:00:00

abstract：:The mammalian hearts have the least regenerative capabilities among tissues and organs. As such, heart regeneration has been and continues to be the ultimate goal in the treatment against acquired and congenital heart diseases. Uncovering such a long-awaited therapy is still extremely challenging in the current settin...

journal_title：Seminars in cell & developmental biology

authors： Witman N,Zhou C,Grote Beverborg N,Sahara M,Chien KR

更新日期：2020-04-01 00:00:00

abstract：:α-synuclein and Tau are proteins prone to pathological misfolding and aggregation that are normally found in the presynaptic and axonal compartments of neurons. Misfolding initiates a homo-oligomerization and aggregation cascade culminating in cerebral accumulation of aggregated α-synuclein and Tau in insoluble protei...

journal_title：Seminars in cell & developmental biology

authors： Yan X,Uronen RL,Huttunen HJ

更新日期：2020-03-01 00:00:00

abstract：:Recent genetic and biochemical evidence has improved our understanding of the pathomechanisms that lead to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating neurodegenerative diseases with overlapping symptoms and causes. Impaired RNA metabolism, enhanced aggregation of protein-RNA...

journal_title：Seminars in cell & developmental biology

authors： Mandrioli J,Mediani L,Alberti S,Carra S

更新日期：2020-03-01 00:00:00

abstract：:Intrinsically disordered proteins as computationally predicted account for ∼1/3 of eukaryotic proteomes, are involved in a plethora of biological functions, and have been linked to several human diseases as a result of their dysfunctions. Here, we present a picture wherein an energetic continuum describes protein stru...

journal_title：Seminars in cell & developmental biology

authors： Moosa MM,Ferreon JC,Ferreon ACM

更新日期：2020-03-01 00:00:00

abstract：:Mitochondria are the key energy-producing organelles and cellular source of reactive species. They are responsible for managing cell life and death by a balanced homeostasis passing through a network of structures, regulated principally via fission and fusion. Herein we discuss about the most advanced findings conside...

journal_title：Seminars in cell & developmental biology

authors： Abate M,Festa A,Falco M,Lombardi A,Luce A,Grimaldi A,Zappavigna S,Sperlongano P,Irace C,Caraglia M,Misso G

更新日期：2020-02-01 00:00:00

abstract：:Inheritance of the mitochondrial genome does not follow the rules of conventional Mendelian genetics. The mitochondrial DNA (mtDNA) is present in many copies per cell and is inherited through the maternal germline. In addition, mutations in the mtDNA will give rise to heteroplasmy, the coexistence of different mtDNA v...

journal_title：Seminars in cell & developmental biology

authors： van den Ameele J,Li AYZ,Ma H,Chinnery PF

更新日期：2020-01-01 00:00:00

abstract：:Regeneration, an ability to replace lost body parts, is widespread across animal species. While mammals poorly regenerate most tissues, teleost fish and urodele amphibians possess remarkable regenerative capacity. Earlier work demonstrated that genes driving regeneration are evolutionarily conserved, indicating that a...

journal_title：Seminars in cell & developmental biology

authors： Rodriguez AM,Kang J

更新日期：2020-01-01 00:00:00

abstract：:Recent developments in the nucleic acid editing technologies have provided a powerful tool to precisely engineer the genome and epigenome for studying many aspects of immune cell differentiation and development as well as several immune mediated diseases (IMDs) including autoimmunity and cancer. Here, we discuss the r...

journal_title：Seminars in cell & developmental biology

authors： Singh DD,Hawkins RD,Lahesmaa R,Tripathi SK

更新日期：2019-12-01 00:00:00

abstract：:Human central nervous system (CNS) regeneration is considered the holy grail of neuroscience research, and is one of the most pressing and difficult questions in biology and science. Despite more than 20 years of work in the field of neural stem cells (NSCs), the area remains in its infancy as our understanding of the...

journal_title：Seminars in cell & developmental biology

authors： Julian D,Hollingsworth EW,Julian K,Imitola J

更新日期：2019-11-01 00:00:00

abstract：:The primary cilium is a cellular antenna found on the surface of many eukaryotic cells, whose main role is to sense and transduce signals that regulate growth, development, and differentiation. Although once believed to be a vestigial organelle without important function, it has become clear that defects in primary ci...

journal_title：Seminars in cell & developmental biology

authors： Hossain D,Tsang WY

更新日期：2019-09-01 00:00:00

abstract：:Recent appraisals of mesenteric anatomy clarify its structure and show a continuous and helical-shaped organ. This new model signifies a departure from the conventional model which described multiple, separate "mesenteries". Renaissance anatomists depicted the mesentery as a continuous structure. Events that led to re...

journal_title：Seminars in cell & developmental biology

authors： Byrnes KG,Walsh D,Lewton-Brain P,McDermott K,Coffey JC

更新日期：2019-08-01 00:00:00