Abstract：
:Traumatic brain injury (TBI) is a neurological condition which affects a large number of individuals worldwide, across all ages. It can lead to major physical, cognitive and psychological impairment, and represents a considerable health cost burden. TBI is a heterogeneous condition and there has been intense effort over the last decade to identify better biomarkers, which would enable an optimum and personalized treatment. The brain is highly enriched in a variety of lipids, including fatty acids, glycerophospholipids, glycerolipids, sterols and sphingolipids. There is accumulating evidence in clinical studies in TBI patients and also in experimental models of TBI, that injury triggers a complex pattern of changes in various lipid classes. Such changes can be detected in blood (plasma/serum), cerebrospinal fluid and also in brain tissue. They provide new insights into the pathophysiology of TBI, and have biomarker potential. Here, we review the various changes reported and discuss the scope and value of these lipid focused studies within the TBI field.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Nessel I,Michael-Titus ATdoi
10.1016/j.semcdb.2020.08.004subject
Has Abstractpub_date
2020-10-06 00:00:00eissn
1084-9521issn
1096-3634pii
S1084-9521(20)30079-3pub_type
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