From small fluctuations to large-scale phase separation: lateral organization in model membranes containing cholesterol.

abstract：:During the course of their classic experiments, Hilde Mangold and Hans Spemann discovered that the dorsal blastopore lip of an amphibian gastrula was able to induce formation of a complete embryonic axis when transplanted into the ventral side of a host gastrula embryo. Since then, the inducing activity of the dorsal ...

journal_title：Seminars in cell & developmental biology

authors： Thisse B,Thisse C

更新日期：2015-06-01 00:00:00

abstract：:Adenosine- and uridine-rich elements (AREs) located in 3'-untranslated regions are the best-known determinants of RNA instability. These elements have also been shown to control translation in certain mRNAs, including mRNAs for prominent pro-inflammatory and tumor growth-related proteins, and physiological anti-inflam...

journal_title：Seminars in cell & developmental biology

authors： Espel E

更新日期：2005-02-01 00:00:00

abstract：:The purpose of this review is to describe the endocrine and local testicular factors that contribute to the regulation of the blood-testis barrier (BTB), using information gained from in vivo and in vitro models of BTB formation during/after puberty, and from the maintenance of BTB function during adulthood. In vivo t...

journal_title：Seminars in cell & developmental biology

authors： Stanton PG

更新日期：2016-11-01 00:00:00

abstract：:Kinesins are enzymes that use the energy of ATP to perform mechanical work. There are approximately 14 families of kinesins within the kinesin superfamily. Family classification is derived primarily from alignments of the sequences of the core motor domain. For this reason, the enzymatic behavior and motility of each ...

journal_title：Seminars in cell & developmental biology

authors： Wordeman L

更新日期：2010-05-01 00:00:00

abstract：:Autophagy, a conserved self-eating process for the bulk degradation of cytoplasmic materials, involves double-membrane autophagosomes formed when an isolation membrane emerges and their direct fusion with lysosomes for degradation. For the early biogenesis of autophagosomes and their later degradation in lysosomes, me...

journal_title：Seminars in cell & developmental biology

authors： Wang Y,Li L,Hou C,Lai Y,Long J,Liu J,Zhong Q,Diao J

更新日期：2016-12-01 00:00:00

abstract：:Angiosperms display a huge variety of floral forms. The development of the ABC-model for floral organ identity, almost 20 years ago, has created an excellent basis for comparative floral development (evo-devo) studies. These have resulted in an increasingly more detailed understanding of the molecular control circuitr...

journal_title：Seminars in cell & developmental biology

authors： Rijpkema AS,Vandenbussche M,Koes R,Heijmans K,Gerats T

更新日期：2010-02-01 00:00:00

abstract：:The intermediate mesoderm is located between the somites and the lateral plate mesoderm and gives rise to renal progenitors that contribute to the three mammalian kidney types (pronephros, mesonephros and metanephros). In this review, focusing largely on murine kidney development, we examine how the intermediate mesod...

journal_title：Seminars in cell & developmental biology

authors： Davidson AJ,Lewis P,Przepiorski A,Sander V

更新日期：2019-07-01 00:00:00

abstract：:The TGF-β ligand superfamily contains at least 40 members, many of which are produced and act within the mammalian testis to facilitate formation of sperm. Their progressive expression at key stages and in specific cell types determines the fertility of adult males, influencing testis development and controlling germl...

journal_title：Seminars in cell & developmental biology

authors： Young JC,Wakitani S,Loveland KL

更新日期：2015-09-01 00:00:00

abstract：:During development, diffusible ligands, known as morphogens, are thought to move across fields of cells, regulating gene expression in a concentration dependent manner. The case for morphogens has been convincingly made for the Decapentapleigic (Dpp), Wingless (Wg) and Hedgehog (Hh) proteins in the Drosophila wing. In...

journal_title：Seminars in cell & developmental biology

authors： Cadigan KM

更新日期：2002-04-01 00:00:00

abstract：:Although largely less numerous and characterized than bacterial secreted effectors, several viral virulence factors are secreted by virus infected cells. However, their mode of secretion only starts to be studied at the molecular level. Several of these viral effectors are secreted using an unconventional secretion pa...

journal_title：Seminars in cell & developmental biology

authors： Schatz M,Tong PBV,Beaumelle B

更新日期：2018-11-01 00:00:00

abstract：:Acquisition of the pluripotent state coincides with epigenetic reprogramming of the X-chromosome. Female embryonic stem cells are characterized by the presence of two active X-chromosomes, cell differentiation by inactivation of one of the two Xs, and induced pluripotent stem cells by reactivation of the inactivated X...

journal_title：Seminars in cell & developmental biology

authors： Kim DH,Jeon Y,Anguera MC,Lee JT

更新日期：2011-06-01 00:00:00

abstract：:Eukaryotic cells have a highly evolved system of protein secretion, and dysfunction in this pathway is associated with many diseases including cancer, infection, metabolic disease and neurological disorders. Most proteins are secreted using the conventional endoplasmic reticulum (ER)/Golgi network and as such, this pa...

journal_title：Seminars in cell & developmental biology

authors： Popa SJ,Stewart SE,Moreau K

更新日期：2018-11-01 00:00:00

abstract：:Hepatic oval cell activation, proliferation, and differentiation has been observed under certain physiological conditions, mainly when the proliferation of existing hepatocytes has been inhibited followed by severe hepatic injury. Hepatic oval cells display a distinct phenotype and have been shown to be a bipotential ...

journal_title：Seminars in cell & developmental biology

authors： Oh SH,Hatch HM,Petersen BE

更新日期：2002-12-01 00:00:00

abstract：:Over two decades, γ-secretase has been the target for extensive therapeutic development due to its pivotal role in pathogenesis of Alzheimer's disease and cancer. However, it has proven to be a challenging task owing to its large set of substrates and our limited understanding of the enzyme's structural and mechanisti...

journal_title：Seminars in cell & developmental biology

authors： Nie P,Vartak A,Li YM

更新日期：2020-09-01 00:00:00

abstract：:The autophagy pathway known also as macroautophagy (herein referred to as autophagy) is characterized by the formation of double-membrane organelles that capture cytosolic material. Based on pathway termination alternatives, autophagy has been divided into degradative and secretory. During degradative autophagy, autop...

journal_title：Seminars in cell & developmental biology

authors： Claude-Taupin A,Bissa B,Jia J,Gu Y,Deretic V

更新日期：2018-11-01 00:00:00

abstract：:Vitamin B12 (cobalamin) is necessary for development of the fetus and child. Pregnant women who are vegetarian or vegan, have Crohn's or celiac disease, or have undergone gastric bypass surgery are at increased risk of B12 deficiency. Low serum levels of B12 have been linked to negative impacts in cognitive, motor, an...

journal_title：Seminars in cell & developmental biology

authors： Pepper MR,Black MM

更新日期：2011-08-01 00:00:00

abstract：:Lipids are now widely considered to play a variety of important roles in T-cell mediated immunity, including serving as antigens. Lipid-based antigens are presented by a specialised group of glycoproteins termed CD1. In humans, three classes of CD1 molecules exist: group 1 (CD1a, CD1b, CD1c), group 2 (CD1d), and group...

journal_title：Seminars in cell & developmental biology

authors： Le Nours J,Shahine A,Gras S

更新日期：2018-12-01 00:00:00

abstract：:Correct orientation of the mitotic spindle is crucial for the proper segregation of localized determinants and the correct spatial organization of cells in early embryos. The cues dividing cells use to orient their mitotic spindles are currently the subject of intensive investigation in a number of model systems. One ...

journal_title：Seminars in cell & developmental biology

authors： Walston TD,Hardin J

更新日期：2006-04-01 00:00:00

abstract：:The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.semcdb.2013.05.010. The duplicate article has therefore been withdrawn. ...

journal_title：Seminars in cell & developmental biology

authors： Lopez-Vernaza MA,Leach DR

更新日期：2013-05-18 00:00:00

abstract：:From the mid-19th century until the 1980's, frogs and toads provided important research models for many fundamental questions in visual neuroscience. In the present century, they have been largely neglected. Yet they are animals with highly developed vision, a complex retina built on the basic vertebrate plan, an acce...

journal_title：Seminars in cell & developmental biology

authors： Donner K,Yovanovich CAM

更新日期：2020-10-01 00:00:00

abstract：:DNA replication normally follows the rules passed down from Watson and Crick: the chromosome duplicates as dictated by its antiparallel strands, base-pairing and leading and lagging strand differences. Real-life replication is more complicated, fraught with perils posed by chromosome damage for one, and by transcripti...

journal_title：Seminars in cell & developmental biology

authors： Carr AM,Paek AL,Weinert T

更新日期：2011-10-01 00:00:00

abstract：:Aluminium salts have been used as adjuvants in vaccines for almost a century, but still no clear understanding of the mechanisms behind the immune stimulating properties of aluminium based adjuvants is recognized. Aluminium adjuvants consist of aggregates and upon administration of a vaccine, the aggregates will be re...

journal_title：Seminars in cell & developmental biology

authors： Danielsson R,Eriksson H

更新日期：2021-01-07 00:00:00

abstract：:A wide range of cellular activities including protein folding and cell secretion, such as neurotransmission or insulin release, are all governed by intracellular pH homeostasis, underscoring the importance of pH on critical life processes. Nano- scale pH measurements of cells and biomolecules therefore hold great prom...

journal_title：Seminars in cell & developmental biology

authors： Lewis KT,Naik AR,Laha SS,Wang S,Mao G,Kuhn E,Jena BP

更新日期：2018-01-01 00:00:00

abstract：:Carotenoids are an important source of metabolites with regulatory function, which include the plant hormones abscisic acid (ABA) and strigolactones (SLs), and several recently identified growth regulators and signaling molecules. These carotenoid-derivatives originate from oxidative breakdown of double bonds in the c...

journal_title：Seminars in cell & developmental biology

authors： Wang JY,Lin PY,Al-Babili S

更新日期：2020-07-27 00:00:00

abstract：:Both types of Drosophila egg chamber germ cells, i.e. oocyte and nurse cells, have to control their nucleus positions in order to produce a viable gamete. Interestingly, while actin microfilaments are crucial to position the nuclei in nurse cells, these are the microtubules that are important for oocyte nucleus to mig...

journal_title：Seminars in cell & developmental biology

authors： Bernard F,Lepesant JA,Guichet A

更新日期：2018-10-01 00:00:00

abstract：:During eye formation, inductive phenomena occurring between retinal pigmented epithelium (RPE) and retina are not well understood. After briefly summarizing the normal development of retina and RPE, we present three-dimensional in vitro models of the chick embryonic retina which allows elucidation of RPE-retina intera...

journal_title：Seminars in cell & developmental biology

authors： Layer PG,Rothermel A,Willbold E

更新日期：1998-06-01 00:00:00

abstract：:The costs and benefits of random phenotypic heterogeneity in microbes have been vigorously debated and experimental tested for decades; yet, this conversation is largely independent from discussion of phenotypic robustness in other disciplines. In this review I connect microbial examples of stochasticity with studies ...

journal_title：Seminars in cell & developmental biology

authors： Draghi J

更新日期：2019-04-01 00:00:00

abstract：:The ability of cells to polarize is an intrinsic property of almost all cells and is required for the devlopment of most multicellular organisms. To develop cell polarity, cells integrate various signals derived from intrinsic as well as extrinsic sources. In the recent years, cell-cell adhesion receptors have turned ...

journal_title：Seminars in cell & developmental biology

authors： Ebnet K,Kummer D,Steinbacher T,Singh A,Nakayama M,Matis M

更新日期：2018-09-01 00:00:00

abstract：:Analysis of membrane transport in the yeast Saccharomyces cerevisiae continues to provide important insights into the molecular mechanisms that direct endocytic and lysosomal sorting pathways in eukaryotic cells. Recent findings include the identification of two novel endomembrane transport pathways, a Golgi-to-vacuol...

journal_title：Seminars in cell & developmental biology

authors： Burd CG,Babst M,Emr SD

更新日期：1998-10-01 00:00:00

abstract：:Autophagy, an evolutional conserved lysosomal degradation process, has been implicated to play an important role in cellular defense against a variety of microbial infection. Interestingly, numerous studies found that some pathogens, especially positive-single-strand RNA viruses, actually hijacked autophagy machinery ...

journal_title：Seminars in cell & developmental biology

authors： Huang L,Yue J

更新日期：2020-05-01 00:00:00