Abstract:
:Autophagy, a conserved self-eating process for the bulk degradation of cytoplasmic materials, involves double-membrane autophagosomes formed when an isolation membrane emerges and their direct fusion with lysosomes for degradation. For the early biogenesis of autophagosomes and their later degradation in lysosomes, membrane fusion is necessary, although different sets of genes and autophagy-related proteins involved in distinct fusion steps have been reported. To clarify the molecular mechanism of membrane fusion in autophagy, to not only expand current knowledge of autophagy, but also benefit human health, this review discusses key findings that elucidate the unique membrane dynamics of autophagy.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Wang Y,Li L,Hou C,Lai Y,Long J,Liu J,Zhong Q,Diao Jdoi
10.1016/j.semcdb.2016.07.009subject
Has Abstractpub_date
2016-12-01 00:00:00pages
97-104eissn
1084-9521issn
1096-3634pii
S1084-9521(16)30204-Xjournal_volume
60pub_type
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