Abstract：
:The ability of cells to polarize is an intrinsic property of almost all cells and is required for the devlopment of most multicellular organisms. To develop cell polarity, cells integrate various signals derived from intrinsic as well as extrinsic sources. In the recent years, cell-cell adhesion receptors have turned out as important regulators of cellular polarization. By interacting with conserved cell polarity proteins, they regulate the recruitment of polarity complexes to specific sites of cell-cell adhesion. By initiating intracellular signaling cascades at those sites, they trigger their specific subcellular activation. Not surprisingly, cell-cell adhesion receptors regulate diverse aspects of cell polarity, including apico-basal polarity in epithelial and endothelial cells, front-to-rear polarity in collectively migrating cells, and planar cell polarity during organ development. Here, we review the recent developments highlighting the central roles of cell-cell adhesion molecules in the development of cell polarity.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Ebnet K,Kummer D,Steinbacher T,Singh A,Nakayama M,Matis Mdoi
10.1016/j.semcdb.2017.07.032subject
Has Abstractpub_date
2018-09-01 00:00:00pages
2-12eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30188-Xjournal_volume
81pub_type
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