Abstract：
:Most mammals cannot easily overcome degenerative disease or traumatic injuries. In contrast, an innate ability to regenerate is observed across animal phyla. Freshwater planarians are amongst the organisms that are capable of stem cell-mediated whole-body regeneration and have served as an exemplary model to study how pluripotency is maintained and regulated in vivo. Here, we review findings on the role of post-translational modifications and the genes regulating phosphorylation, ubiquitylation, and chromatin remodeling in planarian regeneration. Furthermore, we discuss how technological advances for identifying cellular targets of these processes will fill gaps in our knowledge of the signaling mechanisms that underlie regeneration in planarians, which should inform how tissue repair can be stimulated in non-regenerative model organisms and in humans.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Strand NS,Allen JM,Zayas RMdoi
10.1016/j.semcdb.2018.04.009subject
Has Abstractpub_date
2019-03-01 00:00:00pages
58-68eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30196-9journal_volume
87pub_type
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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