Abstract:
:The tight control of reactive oxygen species (ROS) levels is required during regeneration. H2O2 in particular assumes clear signalling functions at different steps in this process. Injured nerves induce high levels of H2O2 through the activation of the Hedgehog (Shh) pathway, providing an environment that promotes cell plasticity, progenitor recruitment and blastema formation. In turn, high H2O2 levels contribute to growing axon attraction. Once re-innervation is completed, nerves subsequently downregulate H2O2 levels to their original state. A similar regulatory loop between H2O2 levels and nerves also exists during development. This suggests that redox signalling is a major actor in cell plasticity.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Meda F,Rampon C,Dupont E,Gauron C,Mourton A,Queguiner I,Thauvin M,Volovitch M,Joliot A,Vriz Sdoi
10.1016/j.semcdb.2017.08.015subject
Has Abstractpub_date
2018-08-01 00:00:00pages
65-73eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30448-2journal_volume
80pub_type
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