Nerves, H2O2 and Shh: Three players in the game of regeneration.

Abstract:

:The tight control of reactive oxygen species (ROS) levels is required during regeneration. H2O2 in particular assumes clear signalling functions at different steps in this process. Injured nerves induce high levels of H2O2 through the activation of the Hedgehog (Shh) pathway, providing an environment that promotes cell plasticity, progenitor recruitment and blastema formation. In turn, high H2O2 levels contribute to growing axon attraction. Once re-innervation is completed, nerves subsequently downregulate H2O2 levels to their original state. A similar regulatory loop between H2O2 levels and nerves also exists during development. This suggests that redox signalling is a major actor in cell plasticity.

journal_name

Semin Cell Dev Biol

authors

Meda F,Rampon C,Dupont E,Gauron C,Mourton A,Queguiner I,Thauvin M,Volovitch M,Joliot A,Vriz S

doi

10.1016/j.semcdb.2017.08.015

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

65-73

eissn

1084-9521

issn

1096-3634

pii

S1084-9521(17)30448-2

journal_volume

80

pub_type

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