Abstract:
:Glutathione (GSH) is the most abundant antioxidant and a major detoxification agent in cells. It is synthesized through two-enzyme reaction catalyzed by glutamate cysteine ligase and glutathione synthetase, and its level is well regulated in response to redox change. Accumulating evidence suggests that GSH may play important roles in cell signaling. This review will focus on the biosynthesis of GSH, the reaction of S-glutathionylation (the conjugation of GSH with thiol residue on proteins), GSNO, and their roles in redox signaling.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Zhang H,Forman HJdoi
10.1016/j.semcdb.2012.03.017subject
Has Abstractpub_date
2012-09-01 00:00:00pages
722-8issue
7eissn
1084-9521issn
1096-3634pii
S1084-9521(12)00070-5journal_volume
23pub_type
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