Unravelling global genome organization by 3C-seq.

Abstract:

:Eukaryotic genomes exist in the cell nucleus as an elaborate three-dimensional structure which reflects various nuclear processes such as transcription, DNA replication and repair. Next-generation sequencing (NGS) combined with chromosome conformation capture (3C), referred to as 3C-seq in this article, has recently been applied to the yeast and human genomes, revealing genome-wide views of functional associations among genes and their regulatory elements. Here, we compare the latest genomic approaches such as 3C-seq and ChIA-PET, and provide a condensed overview of how eukaryotic genomes are functionally organized in the nucleus.

journal_name

Semin Cell Dev Biol

authors

Tanizawa H,Noma K

doi

10.1016/j.semcdb.2011.11.003

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

213-21

issue

2

eissn

1084-9521

issn

1096-3634

pii

S1084-9521(11)00235-7

journal_volume

23

pub_type

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