Abstract:
:The epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptor tyrosine kinases. This family includes EGFR/ErbB1/HER1, ErbB2/HER2/Neu ErbB3/HER3, and ErbB4/HER4. For many years it was believed that EGFR plays a minor role in the development and progression of breast malignancies. However, recent findings have led investigators to revisit these beliefs. Here we will review these findings and propose roles that EGFR may play in breast malignancies. In particular, we will discuss the potential roles that EGFR may play in triple-negative tumors, resistance to endocrine therapies, maintenance of stem-like tumor cells, and bone metastasis. Thus, we will propose the contexts in which EGFR may be a therapeutic target.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Foley J,Nickerson NK,Nam S,Allen KT,Gilmore JL,Nephew KP,Riese DJ 2nddoi
10.1016/j.semcdb.2010.08.009subject
Has Abstractpub_date
2010-12-01 00:00:00pages
951-60issue
9eissn
1084-9521issn
1096-3634pii
S1084-9521(10)00146-1journal_volume
21pub_type
杂志文章,评审abstract::Cancer cachexia is a complex syndrome generated by interaction between the host and tumour cells with a background of treatment effects and toxicity. The complexity of the physiological pathways likely involved in cancer cachexia necessitates a holistic view of the relevant biology. Emergent properties are characteris...
journal_title:Seminars in cell & developmental biology
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doi:10.1016/j.semcdb.2015.12.022
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abstract::Lymphatic contractile dysfunction is central to a number of pathologies that affect millions of people worldwide. Due to its critical role in the process of inflammation, a dysfunctional lymphatic system also compromises the immune response, further exacerbating a number of inflammation related diseases. Despite the c...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.01.005
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journal_title:Seminars in cell & developmental biology
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doi:10.1016/j.semcdb.2016.01.024
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abstract::It is increasingly recognized that the non-neoplastic stromal compartment in most solid cancers plays an active role in tumor proliferation, invasion and metastasis. Cancer-associated fibroblasts (CAFs) are one of the most abundant cell types in the tumor stroma, and these cells are pro-tumorigenic. Evidence that CAFs...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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abstract::The costs and benefits of random phenotypic heterogeneity in microbes have been vigorously debated and experimental tested for decades; yet, this conversation is largely independent from discussion of phenotypic robustness in other disciplines. In this review I connect microbial examples of stochasticity with studies ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2018.05.017
更新日期:2019-04-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a prevalent inflammatory joint disease with enigmatic flares, which causes swelling, pain, and irreversible connective tissue damage. Recently, it has been demonstrated in murine models of RA that the popliteal lymph node (PLN) is a biomarker of arthritic flare, as it "expands" in size and...
journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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abstract::Autophagy, a conserved self-eating process for the bulk degradation of cytoplasmic materials, involves double-membrane autophagosomes formed when an isolation membrane emerges and their direct fusion with lysosomes for degradation. For the early biogenesis of autophagosomes and their later degradation in lysosomes, me...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2012.09.011
更新日期:2012-10-01 00:00:00
abstract::The design and analysis of experiments using gene expression microarrays is a topic of considerable current research, and work is beginning to appear on the analysis of proteomics and metabolomics data by mass spectrometry and NMR spectroscopy. The literature in this area is evolving rapidly, and commercial software f...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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更新日期:2004-12-01 00:00:00
abstract::Precise control of neural progenitor transformation into neural crest stem cells ensures proper craniofacial and head development. In the neural progenitor pool, SoxB factors play an essential role as cell fate determinants of neural development, whereas during neural crest stem cell formation, Sox2 plays a predominan...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2016.08.035
更新日期:2017-03-01 00:00:00
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2016.09.012
更新日期:2017-04-01 00:00:00
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.2000.0164
更新日期:2000-06-01 00:00:00
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.2000.0175
更新日期:2000-08-01 00:00:00
abstract::We describe in this review increasing evidence that loss of LKB1 kinase in Peutz-Jeghers syndrome (PJS) derails the existing natural balance between cell survival and tumour growth suppression. LKB1 deletion can plunge cells into an energy/oxidative stress-induced crisis which leads to the activation of alternative an...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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更新日期:2016-04-01 00:00:00
abstract::Inflammation is a natural part of wound healing but it can also cause secondary (bystander) damage and/or negatively interfere with endogenous repair mechanisms if non-resolving. Regulation of inflammation is traditionally looked at from the perspective of danger signals, cytokines and chemokines, and their respective...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2016.08.010
更新日期:2017-01-01 00:00:00
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.1999.0347
更新日期:2000-02-01 00:00:00
abstract::A number of proteins produced by certain bacteria and plants are potently toxic to mammalian cells. This toxicity results from their ability to catalytically modify macromolecules that are required for essential cellular functions such as vesicular trafficking, cytoskeletal assembly, signalling or protein synthesis. T...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2004.03.005
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abstract::Viruses have evolved strategies to evade immunity mediated by antibody and complement. Herpesviruses and coronaviruses encode IgG Fc binding proteins that inhibit IgG activity, enabling the virus or infected cell to escape antibody attack. Herpesviruses, vaccinia virus and HIV-1 have the capacity to interfere with com...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.1998.0242
更新日期:1998-06-01 00:00:00
abstract::In the crowded intranuclear environment, entropic depletion forces between macromolecules are expected to be strong. A review of simulations of linear polymers leads to several predictions about probable conformations of a polynucleosome chain in these conditions. These include a globular conformation, variable compac...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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更新日期:2007-10-01 00:00:00
abstract::Polycystic kidney disease (PKD), comprising autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD), is characterized by incessant cyst formation in the kidney and liver. ADPKD and ARPKD represent the leading genetic causes of renal disease in adults and children,...
journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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abstract::The intestine has long been studied as a model for adult stem cells due to the life-long self-renewal of the intestinal epithelium through the proliferation of the adult intestinal stem cells. Recent evidence suggests that the formation of adult intestinal stem cells in mammals takes place during the thyroid hormone-d...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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更新日期:2017-03-01 00:00:00
abstract::The autophagy pathway known also as macroautophagy (herein referred to as autophagy) is characterized by the formation of double-membrane organelles that capture cytosolic material. Based on pathway termination alternatives, autophagy has been divided into degradative and secretory. During degradative autophagy, autop...
journal_title:Seminars in cell & developmental biology
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abstract::Macroscopic coexisting liquid phases are readily observed in certain model membranes containing cholesterol and at least two other lipid components. Recent fluorescence microscopy and deuterium NMR work indicates that submicron fluctuations are also found, in vesicles with near-critical lipid compositions. In principl...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2007.08.016
更新日期:2007-10-01 00:00:00
abstract::Spatial patterns of neuronal connectivity are critical for neural circuit function and information processing. For many neuron types, the development of stereotyped dendritic and axonal territories involves reiterative contacts between neurites and successive re-calibration of branch outgrowth and directionality. Here...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00
abstract::In the recent years several papers and some reviews have dealt with characterization, localization and influence on the precipitation of calcium carbonate, of the organic matrix from scleractinian corals. In fact, it has been well established that coral calcification is a biological controlled process orchestrated in ...
journal_title:Seminars in cell & developmental biology
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doi:10.1016/j.semcdb.2015.09.005
更新日期:2015-10-01 00:00:00
abstract::Tumor progression and dissemination critically depend on support from the tumor microenvironment, the ensemble of cellular and acellular components surrounding and interacting with tumor cells. The extracellular matrix (ECM), the complex scaffolding of hundreds of proteins organizing cells in tissues, is a major compo...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2018.06.005
更新日期:2019-05-01 00:00:00
abstract::During the development of vertebrate nervous system, distinct classes of motor neurons and interneurons are generated at distinct dorsoventral positions in the ventral neural tube. The differentiation of these neuronal subtypes is directed by the secreted protein Sonic Hedgehog (Shh). Shh acts in a graded manner to es...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.1999.0295
更新日期:1999-06-01 00:00:00
abstract::Mammalian core binding factor beta (CBFbeta) and Drosophila Brother (Bro) and Big-brother (Bgb) proteins are transcription factors that dimerize with mammalian Runx and Drosophila Runt and Lozenge proteins and augment their DNA binding affinity and transcriptional potency. CBFbeta is essential for development and sust...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.2000.0189
更新日期:2000-10-01 00:00:00