Abstract：
:Wnt signaling is a hallmark of all embryonic development with multiple roles at multiple developmental time points. Wnt signaling is also important in the development of several organs, one of which is the inner ear, where it participates in otic specification, the formation of vestibular structures, and the development of the cochlea. In particular, we focus on Wnt signaling in the auditory organ, the cochlea. Attempting to dissect the multiple Wnt signaling pathways in the mammalian cochlea is a challenging task due to limited expression data, particularly at proliferating stages. To offer predictions about Wnt activity, we compare cochlear development with that of other biological systems such as Xenopus retina, brain, cancer cells and osteoblasts. Wnts are likely to regulate development through crosstalk with other signaling pathways, particularly Notch and FGF, leading to changes in the expression of Sox2 and proneural (pro-hair cell) genes. In this review we have consolidated the known signaling pathways in the cochlea with known developmental roles of Wnts from other systems to generate a potential timeline of cochlear development.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Munnamalai V,Fekete DMdoi
10.1016/j.semcdb.2013.03.008subject
Has Abstractpub_date
2013-05-01 00:00:00pages
480-9issue
5eissn
1084-9521issn
1096-3634pii
S1084-9521(13)00044-Xjournal_volume
24pub_type
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