Abstract:
:Neural stem cells (NSCs) are subscribed extraordinary potential in repair of the damaged nervous system. However, the molecular identity of NSCs has not been established. Most NSC cultures contain large numbers of multipotent, bipotent, and lineage restricted neural progenitors, the majority of which appear to lose neurogenic potential after expansion. This review first discusses the neurogenic to gliogenic switch that is characteristic of progenitor development in vivo and in NSC cultures, and then the cell intrinsic and extrinsic mechanisms regulating the sequential differentiation of neurons and glia. Finally, we discuss potential methods for maintaining the neurogenic potential of NSC cultures after expansion.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Sun YE,Martinowich K,Ge Wdoi
10.1016/s1084-9521(03)00007-7subject
Has Abstractpub_date
2003-06-01 00:00:00pages
161-8issue
3eissn
1084-9521issn
1096-3634pii
S1084-9521(03)00007-7journal_volume
14pub_type
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