Abstract:
:When entering tissues, monocytes can differentiate into cells that share morphological and functional features with either dendritic cells (DC) or macrophages. Monocyte-derived DC have been observed in humans at mucosal tissues and in inflammatory settings, where they are usually referred to as «inflammatory DC». In this chapter, we review recent studies on the characterization of these cells in humans. We also discuss nomenclature and examine the criteria defining in vivo-differentiated human mo-DC.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Tang-Huau TL,Segura Edoi
10.1016/j.semcdb.2018.02.018subject
Has Abstractpub_date
2019-02-01 00:00:00pages
44-49eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30362-2journal_volume
86pub_type
杂志文章,评审abstract::During vertebrate gastrulation, large cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish offer many genetic and experimental advantages for studying vertebrate gastrulation movements. For instance, several mutants, including silberblick, knypek and trilob...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/s1084952102001003
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abstract::During eye formation, inductive phenomena occurring between retinal pigmented epithelium (RPE) and retina are not well understood. After briefly summarizing the normal development of retina and RPE, we present three-dimensional in vitro models of the chick embryonic retina which allows elucidation of RPE-retina intera...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.1998.0234
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abstract::The endoplasmic reticulum (ER) is an intracellular compartment devoted to the synthesis, segregation and folding of soluble and membrane secretory proteins. Some mutations in these proteins lead to their incorrect or incomplete folding in the ER. The ER has a quality control system which detects misfolded proteins and...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.1999.0316
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abstract::Hepatic oval cell activation, proliferation, and differentiation has been observed under certain physiological conditions, mainly when the proliferation of existing hepatocytes has been inhibited followed by severe hepatic injury. Hepatic oval cells display a distinct phenotype and have been shown to be a bipotential ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/s1084952102001271
更新日期:2002-12-01 00:00:00
abstract::The extracellular matrix (ECM) consists of a complex mixture of structural and functional proteins and serves an important role in tissue and organ morphogenesis, maintenance of cell and tissue structure and function, and in the host response to injury. Xenogeneic and allogeneic ECM has been used as a bioscaffold for ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/s1084952102000940
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abstract::The ABC model postulates that expression combinations of three classes of genes (A, B and C) specify the four floral organs at early stages of flower development. This classic model provides a solid framework to study flower development and has been the foundation for multiple studies in different plant species, as we...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2009.11.010
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abstract::There has been widespread speculation regarding the possibility of reprogramming human somatic nuclei by transfer into oocytes. Stem cells derived from such reconstructed embryos could theoretically provide a source of autologous tissue for therapeutic transplantation. However the biological, technical and ethical hur...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.1999.0277
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abstract::The Mediator is a large, multisubunit RNA polymerase II transcriptional regulator that was first identified in Saccharomyces cerevisiae as a factor required for responsiveness of Pol II and the general initiation factors to DNA binding transactivators. Since its discovery in yeast, Mediator has been shown to be an int...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2011.07.021
更新日期:2011-09-01 00:00:00
abstract::Discovering how organisms and their proteins adapt to extreme conditions is a complicated process. Every condition has its own set of adaptations that make it uniquely stable in its environment. The purpose of our review is to discuss what is known in the extremophilic community about protein adaptations. To simplify ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2017.12.016
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abstract::Blood vessels are essential conduits of nutrients and oxygen throughout the body. The formation of these vessels involves angiogenic sprouting, a complex process entailing highly integrated cell behaviors and signaling pathways. In this review, we discuss how endothelial cells initiate a vessel sprout through interact...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2011.10.006
更新日期:2011-12-01 00:00:00
abstract::The functional unit of the mammalian metanephric kidney is the nephron: a complex tubular structure dedicated to blood filtration and maintenance of several important physiological functions. Nephrons are assembled from a nephron-restricted pool of mesenchymal progenitors over an extensive developmental period that is...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2014.08.014
更新日期:2014-12-01 00:00:00
abstract::α-synuclein and Tau are proteins prone to pathological misfolding and aggregation that are normally found in the presynaptic and axonal compartments of neurons. Misfolding initiates a homo-oligomerization and aggregation cascade culminating in cerebral accumulation of aggregated α-synuclein and Tau in insoluble protei...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2018.05.005
更新日期:2020-03-01 00:00:00
abstract::Caspases are cysteine proteases that play important and well-defined roles in apoptosis and inflammation. Increasing evidence point to alternative functions of caspases where restricted and localized caspase activation within neurons allows for a variety of non-apoptotic and non-inflammatory processes required for bra...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2017.11.037
更新日期:2018-10-01 00:00:00
abstract::Growth factors acting through receptor tyrosine kinases (RTKs) of ERBB family, along with steroid hormones (SH) acting through nuclear receptors (NRs), are critical signalling mediators of cellular processes. Deregulations of ERBB and steroid hormone receptors are responsible for several diseases, including cancer, th...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.11.004
更新日期:2016-02-01 00:00:00
abstract::Since the first implication of the core planar cell polarity (PCP) pathway in stereocilia orientation of sensory hair cells in the mammalian cochlea, much has been written about this subject, in terms of understanding how this pathway can shape the mammalian hair cells and using the inner ear as a model system to unde...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2013.03.012
更新日期:2013-05-01 00:00:00
abstract::Controlling gene expression is one of the most fundamental task of living organisms, from prokaryotes to higher eukaryotes, in order to develop, grow, and reproduce in an ever changing environment. In many cases, the expression status of a given gene is controlled independently of that of its neighbours through locali...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2003.09.014
更新日期:2003-12-01 00:00:00
abstract::The notion of feedback is fundamental for understanding signal transduction networks. Feedback loops attenuate or amplify signals, change the network dynamics and modify the input-output relationships between the signal and the target. Negative feedback provides robustness to noise and adaptation to perturbations, but...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.09.024
更新日期:2016-02-01 00:00:00
abstract::Adenosine- and uridine-rich elements (AREs) located in 3'-untranslated regions are the best-known determinants of RNA instability. These elements have also been shown to control translation in certain mRNAs, including mRNAs for prominent pro-inflammatory and tumor growth-related proteins, and physiological anti-inflam...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2004.11.008
更新日期:2005-02-01 00:00:00
abstract::Lipids are now widely considered to play a variety of important roles in T-cell mediated immunity, including serving as antigens. Lipid-based antigens are presented by a specialised group of glycoproteins termed CD1. In humans, three classes of CD1 molecules exist: group 1 (CD1a, CD1b, CD1c), group 2 (CD1d), and group...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2017.11.002
更新日期:2018-12-01 00:00:00
abstract::Embryonic development is a complex and highly dynamic process during which individual cells interact with one another, adopt different identities and organize themselves in three-dimensional space to generate an entire organism. Recent technical developments in genomics and high-resolution quantitative imaging are mak...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.06.004
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abstract::The simple mechanistic and functional division of the kinesin family into either active translocators or non-motile microtubule depolymerases was initially appropriate but is now proving increasingly unhelpful, given evidence that several translocase kinesins can affect microtubule dynamics, whilst non-translocase kin...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2011.09.021
更新日期:2011-12-01 00:00:00
abstract::Autophagy, a conserved self-eating process for the bulk degradation of cytoplasmic materials, involves double-membrane autophagosomes formed when an isolation membrane emerges and their direct fusion with lysosomes for degradation. For the early biogenesis of autophagosomes and their later degradation in lysosomes, me...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2016.07.009
更新日期:2016-12-01 00:00:00
abstract::The role of the tight junctions (TJ) in controlling paracellular traffic of ions and molecules, through the regulation of claudin proteins, is now established. However, it has also become increasingly evident that claudin proteins, as integral components of the TJs, play crucial role in maintaining the cell-cell integ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.05.001
更新日期:2015-06-01 00:00:00
abstract::Myocardial infarction results in scar tissue that cannot actively contribute to heart mechanical function and frequently causes lethal arrhythmias. The healing response after infarction involves inflammation, biochemical signaling, changes in cellular phenotype, activity, and organization, and alterations in electrica...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2016.05.020
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abstract::IgE-mediated food allergy is a developing global health problem with prevalence rising at alarmingly fast rates. In this review, we discuss the interplay between genetics, epigenetics, and environmental exposures in the pathogenesis of food allergies. We aim to highlight the most recent evidence that suggests how epig...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.07.002
更新日期:2015-07-01 00:00:00
abstract::UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I (GnTI, encoded by Mgat1) first appeared in evolution at about the same time as metazoa suggesting that GnTI-dependent glycans are essential for the development of multicellular organisms. This review describes the effects of mutations in the Mgat1...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2010.02.010
更新日期:2010-08-01 00:00:00
abstract::Additional copies of genes resulting from two whole genome duplications at the base of the vertebrates have been suggested as enabling the evolution of vertebrate-specific structures such as neural crest, a midbrain/hindbrain organizer and neurogenic placodes. These structures, however, did not evolve entirely de novo...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2012.12.007
更新日期:2013-02-01 00:00:00
abstract::The exchange of substances between metazoan and the environment takes place across transporting epithelia that have two fundamental differentiated features: tight junctions (TJ) and apical/basolateral polarity. Usually, reviews of the structure and function of transporting epithelia follow a historical description of ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2014.09.010
更新日期:2014-12-01 00:00:00
abstract::The actin cytoskeleton is critically involved in a variety of cell functions. The Arp2/3 complex mediates branching of filamentous actin. The members of the Wiskott-Aldrich syndrome protein (WASP) family are major regulators of the complex. As such, the family proteins are also involved in numerous aspects of cell bio...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2013.03.002
更新日期:2013-04-01 00:00:00
abstract::Correct orientation of the mitotic spindle is crucial for the proper segregation of localized determinants and the correct spatial organization of cells in early embryos. The cues dividing cells use to orient their mitotic spindles are currently the subject of intensive investigation in a number of model systems. One ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2006.04.005
更新日期:2006-04-01 00:00:00