Introduction: Making and filling gene-expression developmental databases

abstract：:The costs and benefits of random phenotypic heterogeneity in microbes have been vigorously debated and experimental tested for decades; yet, this conversation is largely independent from discussion of phenotypic robustness in other disciplines. In this review I connect microbial examples of stochasticity with studies ...

journal_title：Seminars in cell & developmental biology

authors： Draghi J

更新日期：2019-04-01 00:00:00

abstract：:The actin cytoskeleton is critically involved in a variety of cell functions. The Arp2/3 complex mediates branching of filamentous actin. The members of the Wiskott-Aldrich syndrome protein (WASP) family are major regulators of the complex. As such, the family proteins are also involved in numerous aspects of cell bio...

journal_title：Seminars in cell & developmental biology

authors： Oda A,Eto K

更新日期：2013-04-01 00:00:00

abstract：:At fertilisation, Ca(2+) signals activate embryonic development by stimulating metabolism, exocytosis and endocytosis, cytoskeletal remodelling, meiotic resumption and recruitment of maternal RNAs. Mitochondria present in large number in eggs have long been thought to act as a relay in Ca(2+) signalling at fertilisati...

journal_title：Seminars in cell & developmental biology

authors： Dumollard R,Duchen M,Sardet C

更新日期：2006-04-01 00:00:00

abstract：:Fibrillin microfibrils are extensible polymers that endow connective tissues with long-range elasticity and have widespread distributions in both elastic and non-elastic tissues. They act as a template for elastin deposition during elastic fibre formation and are essential for maintaining the integrity of tissues such...

journal_title：Seminars in cell & developmental biology

authors： Thomson J,Singh M,Eckersley A,Cain SA,Sherratt MJ,Baldock C

更新日期：2019-05-01 00:00:00

abstract：:Correct orientation of the mitotic spindle is crucial for the proper segregation of localized determinants and the correct spatial organization of cells in early embryos. The cues dividing cells use to orient their mitotic spindles are currently the subject of intensive investigation in a number of model systems. One ...

journal_title：Seminars in cell & developmental biology

authors： Walston TD,Hardin J

更新日期：2006-04-01 00:00:00

abstract：:The question of how the physical dimensions of animal organs are specified has long fascinated both experimentalists and computational scientists working in the field of developmental biology. Research over the last few decades has identified many of the genes and signaling pathways involved in organizing the emergent...

journal_title：Seminars in cell & developmental biology

authors： Buchmann A,Alber M,Zartman JJ

更新日期：2014-11-01 00:00:00

abstract：:Adenosine- and uridine-rich elements (AREs) located in 3'-untranslated regions are the best-known determinants of RNA instability. These elements have also been shown to control translation in certain mRNAs, including mRNAs for prominent pro-inflammatory and tumor growth-related proteins, and physiological anti-inflam...

journal_title：Seminars in cell & developmental biology

authors： Espel E

更新日期：2005-02-01 00:00:00

abstract：:Mammalian spermatogenesis is a tightly coordinated process that gives rise to mature spermatozoa capable of fertilising an ovum during sexual reproduction. A population of stem and progenitor cells known as undifferentiated spermatogonia enables continual spermatogenesis throughout life. A complex transcriptional netw...

journal_title：Seminars in cell & developmental biology

authors： Legrand JMD,Hobbs RM

更新日期：2018-07-01 00:00:00

abstract：:Cyclic adenosine 3,'5'-monophosphate (cAMP) is the archetypal second messenger produced at the membrane by adenylyl cyclase following activation of many different G protein-coupled receptor (GPCR) types. Although discovered over fifty years ago, the notion that cAMP responses were compartmentalised was born in the 198...

journal_title：Seminars in cell & developmental biology

authors： Edwards HV,Christian F,Baillie GS

更新日期：2012-04-01 00:00:00

abstract：:Phosphatidylinositols are important in intracellular signaling. In response to extracellular signals, these molecules undergo rapid turnover and generate second messengers including diacylglycerol, inositol 1,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate (PtdIns 3,4P2) and phosphatidylinositol 3,4,5-trispho...

journal_title：Seminars in cell & developmental biology

authors： Zhang X,Majerus PW

更新日期：1998-04-01 00:00:00

abstract：:Both types of Drosophila egg chamber germ cells, i.e. oocyte and nurse cells, have to control their nucleus positions in order to produce a viable gamete. Interestingly, while actin microfilaments are crucial to position the nuclei in nurse cells, these are the microtubules that are important for oocyte nucleus to mig...

journal_title：Seminars in cell & developmental biology

authors： Bernard F,Lepesant JA,Guichet A

更新日期：2018-10-01 00:00:00

abstract：:Freshwater planarians are well known for their remarkable plasticity and regenerative capabilities. Most studies of planarian regeneration have specifically examined regeneration after transverse or longitudinal sectioning or during homeostasis in intact adults. However, tissue transplantation, first performed over a ...

journal_title：Seminars in cell & developmental biology

authors： Rojo-Laguna JI,Garcia-Cabot S,Saló E

更新日期：2019-03-01 00:00:00

abstract：:The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.semcdb.2013.05.010. The duplicate article has therefore been withdrawn. ...

journal_title：Seminars in cell & developmental biology

authors： Lopez-Vernaza MA,Leach DR

更新日期：2013-05-18 00:00:00

abstract：:The primary cilium is a cellular antenna found on the surface of many eukaryotic cells, whose main role is to sense and transduce signals that regulate growth, development, and differentiation. Although once believed to be a vestigial organelle without important function, it has become clear that defects in primary ci...

journal_title：Seminars in cell & developmental biology

authors： Hossain D,Tsang WY

更新日期：2019-09-01 00:00:00

abstract：:Low oxygen adaptation is essential for aerobic fungi that must survive in varied oxygen environments. Pathogenic fungi in particular must adapt to the low oxygen host tissue environment in order to cause infection. Maintenance of lipid homeostasis is especially important for cell growth and proliferation, and is a hig...

journal_title：Seminars in cell & developmental biology

authors： Burr R,Espenshade PJ

更新日期：2018-09-01 00:00:00

abstract：:The vast amount of recent progress made on the sequence of the human genome has allowed an unprecedented examination of cis-regulatory networks. These networks consist of functional elements such as promoters, enhancers, silencers, and insulators, and their coordinated activity is responsible for regulation of gene ex...

journal_title：Seminars in cell & developmental biology

authors： Cecchini KR,Raja Banerjee A,Kim TH

更新日期：2009-09-01 00:00:00

abstract：:Research using Xenopus laevis has made enormous contributions to our understanding of vertebrate development, control of the eukaryotic cell cycle and the cytoskeleton. One limitation, however, has been the lack of systematic genetic studies in Xenopus to complement molecular and cell biological investigations. Work w...

journal_title：Seminars in cell & developmental biology

authors： Carruthers S,Stemple DL

更新日期：2006-02-01 00:00:00

abstract：:The first lineage segregation event in mouse embryos produces two separate cell populations: inner cell mass and trophectoderm. This is understood to be brought about by cells sensing their position within the embryo and differentiating accordingly. The cellular and molecular underpinnings of this process remain under...

journal_title：Seminars in cell & developmental biology

authors： Biggins JS,Royer C,Watanabe T,Srinivas S

更新日期：2015-12-01 00:00:00

abstract：:Gene duplication events produce both perfect and imperfect copies of genes. Perfect copies are said to be functionally redundant when knockout of one gene produces no 'scoreable', phenotypic effects. Preserving identical, duplicate copies of genes is problematic as all copies are prone to accumulate neutral mutations ...

journal_title：Seminars in cell & developmental biology

authors： Krakauer DC,Nowak MA

更新日期：1999-10-01 00:00:00

abstract：:Demyelinating disorders of the central white matter are among the most prevalent and disabling conditions in neurology. Since myelin-producing oligodendrocytes comprise the principal cell type deficient or lost in these conditions, their replacement by new cells generated from transplanted bipotential oligodendrocyte-...

journal_title：Seminars in cell & developmental biology

authors： Goldman SA,Mariani JN,Madsen PM

更新日期：2021-01-04 00:00:00

abstract：:The pancreas is a compound gland comprised of both exocrine acinar and duct cells as well as endocrine islet cells. Most notable amongst the latter are the insulin-synthesizing β-cells, loss or dysfunction of which manifests in diabetes mellitus. All exocrine and endocrine cells derive from multipotent pancreatic prog...

journal_title：Seminars in cell & developmental biology

authors： Seymour PA,Serup P

更新日期：2019-08-01 00:00:00

abstract：:Polycomb group (PcG) proteins play essential roles in animal and plant life cycles by controlling the expression of important developmental regulators. These structurally heterogeneous proteins form multimeric protein complexes that control higher order chromatin structure and, thereby, the expression state of their t...

journal_title：Seminars in cell & developmental biology

authors： Reyes JC,Grossniklaus U

更新日期：2003-02-01 00:00:00

abstract：:The vertebrate ocular lens is a fascinating and unique transparent tissue that grows continuously throughout life. During the process of differentiation into fiber cells, lens epithelial cells undergo dramatic morphological changes, membrane remodeling, polarization, transcriptional activation and elimination of cellu...

journal_title：Seminars in cell & developmental biology

authors： Rao PV,Maddala R

更新日期：2006-12-01 00:00:00

abstract：:Any type of tubulogenesis is a process that is highly coordinated between large numbers of cells. Like other morphogenetic processes, it is driven to a great extent by complex cell shape changes and cell rearrangements. The formation of the salivary glands in the fly embryo provides an ideal model system to study thes...

journal_title：Seminars in cell & developmental biology

authors： Girdler GC,Röper K

更新日期：2014-07-01 00:00:00

abstract：:X inactivation, a developmental process that takes place in early stages of mammalian embryogenesis, balances the sex difference in dosage of X-linked genes. Although all mammals use this form of dosage compensation, the details differ from one species to another because of variations in the staging of embryogenesis a...

journal_title：Seminars in cell & developmental biology

authors： Migeon BR

更新日期：2016-08-01 00:00:00

abstract：:Clustered protocadherins mediate neuronal self-recognition and non-self discrimination-neuronal "barcoding"-which underpin neuronal self-avoidance in vertebrate neurons. Recent structural, biophysical, computational, and cell-based studies on protocadherin structure and function have led to a compelling molecular mode...

journal_title：Seminars in cell & developmental biology

authors： Rubinstein R,Goodman KM,Maniatis T,Shapiro L,Honig B

更新日期：2017-09-01 00:00:00

abstract：:Neural stem cells (NSCs) are subscribed extraordinary potential in repair of the damaged nervous system. However, the molecular identity of NSCs has not been established. Most NSC cultures contain large numbers of multipotent, bipotent, and lineage restricted neural progenitors, the majority of which appear to lose ne...

journal_title：Seminars in cell & developmental biology

authors： Sun YE,Martinowich K,Ge W

更新日期：2003-06-01 00:00:00

abstract：:Eph receptor tyrosine kinases mediate cell-cell communication by interacting with ephrin ligands residing on adjacent cell surfaces. In doing so, these juxtamembrane signaling complexes provide important contextual information about the cellular microenvironment that helps orchestrate tissue morphogenesis and maintain...

journal_title：Seminars in cell & developmental biology

authors： Lin S,Wang B,Getsios S

更新日期：2012-02-01 00:00:00

abstract：:Extracellular vesicles (EVs) act as carriers of molecular and oncogenic signatures present in subsets of tumour cells and tumour-associated stroma, and as mediators of intercellular communication. These processes likely involve cancer stem cells (CSCs). EVs represent a unique pathway of cellular export and cell-to-cel...

journal_title：Seminars in cell & developmental biology

authors： Nakano I,Garnier D,Minata M,Rak J

更新日期：2015-04-01 00:00:00

abstract：:Epithelial cell organization relies on a set of proteins that interact in an intricate way and which are called polarity complexes. These complexes are involved in the determination of the apico-basal axis and in the positioning and stability of the cell-cell junctions called adherens junctions at the apico-lateral bo...

journal_title：Seminars in cell & developmental biology

authors： Bazellières E,Aksenova V,Barthélémy-Requin M,Massey-Harroche D,Le Bivic A

更新日期：2018-09-01 00:00:00