Abstract:
:Cyclic adenosine 3,'5'-monophosphate (cAMP) is the archetypal second messenger produced at the membrane by adenylyl cyclase following activation of many different G protein-coupled receptor (GPCR) types. Although discovered over fifty years ago, the notion that cAMP responses were compartmentalised was born in the 1980s. Since then, modern molecular techniques have facilitated visualisation of cellular cAMP dynamics in real time and helped us to understand how a single, ubiquitous second messenger can direct receptor-specific functions in cells. The aim of this review is to highlight emerging ideas in the cAMP field that are currently developing the concept of compartmentalised cAMP signalling systems.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Edwards HV,Christian F,Baillie GSdoi
10.1016/j.semcdb.2011.09.005subject
Has Abstractpub_date
2012-04-01 00:00:00pages
181-90issue
2eissn
1084-9521issn
1096-3634pii
S1084-9521(11)00141-8journal_volume
23pub_type
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