Abstract:
:Embryonic development is a complex and highly dynamic process during which individual cells interact with one another, adopt different identities and organize themselves in three-dimensional space to generate an entire organism. Recent technical developments in genomics and high-resolution quantitative imaging are making it possible to study cellular populations at single-cell resolution and begin to integrate different inputs, for example genetic, physical and chemical factors, that affect cell differentiation over spatial and temporal scales. The preimplantation mouse embryo allows the analysis of cell fate decisions in vivo with high spatiotemporal resolution. In this review we highlight how the application of live imaging and single-cell resolution analysis pipelines is providing an unprecedented level of insight on the processes that shape the earliest stages of mammalian development.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Saiz N,Plusa B,Hadjantonakis AKdoi
10.1016/j.semcdb.2015.06.004subject
Has Abstractpub_date
2015-12-01 00:00:00pages
92-100eissn
1084-9521issn
1096-3634pii
S1084-9521(15)00123-8journal_volume
47-48pub_type
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