Abstract：
:The exchange of substances between metazoan and the environment takes place across transporting epithelia that have two fundamental differentiated features: tight junctions (TJ) and apical/basolateral polarity. Usually, reviews of the structure and function of transporting epithelia follow a historical description of major biological findings, but seldom refer to the fact that it also required fundamental theoretical changes in the physics and chemistry involved. We make a brief description of the concatenation of both types of achievements, in which it becomes clear that the major source of conflicts was the enzyme Na(+),K(+)-ATPase (also referred to as "the pump"), because of its intrinsic mechanisms and its asymmetric expression on one side of epithelial cells only (polarity). This enzyme is also the receptor of the newly recognized hormone ouabain, whose chief function is to modulate cell contacts, such as TJs, several types of cell-cell contacts participating in polarization (as gauged through ciliogenesis).
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Larre I,Ponce A,Franco M,Cereijido Mdoi
10.1016/j.semcdb.2014.09.010subject
Has Abstractpub_date
2014-12-01 00:00:00pages
149-56eissn
1084-9521issn
1096-3634pii
S1084-9521(14)00265-1journal_volume
36pub_type
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