Abstract：
:gamma-Secretase is a membrane-embedded proteolytic complex composed of presenilin and three other subunits. The gamma-secretase complex generates the amyloid beta-peptide of Alzheimer's disease but also plays important roles in normal physiology, especially in signaling from the Notch receptor. How this hydrolytic enzyme works in a hydrophobic environment is largely unanswered, but mutagenesis and chemical probes have offered insight. gamma-Secretase is an important therapeutic target, although mechanism-based toxicity presents a serious obstacle. Agents that lower amyloid beta-peptide production while leaving important normal functions of gamma-secretase intact are promising therapeutic leads. Inhibition of Notch signaling by gamma-secretase inhibitors, which is undesirable for the prevention or treatment of Alzheimer's disease, may be beneficial for the treatment of a variety of cancers.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Wolfe MSdoi
10.1016/j.semcdb.2008.12.011subject
Has Abstractpub_date
2009-04-01 00:00:00pages
219-24issue
2eissn
1084-9521issn
1096-3634pii
S1084-9521(08)00156-0journal_volume
20pub_type
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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abstract：:The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.semcdb.2013.05.010. The duplicate article has therefore been withdrawn. ...
journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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abstract：:The Endosomal Sorting Complex Required for Transport (ESCRT) proteins form an evolutionarily conserved membrane remodelling machinery. Identified originally for their role in cargo sorting and remodelling of endosomal membranes during yeast vacuolar sorting, an extensive body of work now implicates a sub-complex of th...
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