Abstract：
:Mature skeletal muscle forms from the fusion of skeletal muscle precursor cells, myoblasts. Myoblasts fuse to other myoblasts to generate multinucleate myotubes during myogenesis, and myoblasts also fuse to other myotubes during muscle growth and repair. Proteins within myoblasts and myotubes regulate complex processes such as elongation, migration, cell adherence, cytoskeletal reorganization, membrane coalescence, and ultimately fusion. Recent studies have identified cell surface proteins, intracellular proteins, and extracellular signaling molecules required for the proper fusion of muscle. Many proteins that actively participate in myoblast fusion also coordinate membrane repair. Here we will review mammalian membrane fusion with specific attention to proteins that mediate myoblast fusion and muscle repair.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Demonbreun AR,Biersmith BH,McNally EMdoi
10.1016/j.semcdb.2015.10.026subject
Has Abstractpub_date
2015-09-01 00:00:00pages
48-56eissn
1084-9521issn
1096-3634pii
S1084-9521(15)00223-2journal_volume
45pub_type
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