Oxygen-responsive transcriptional regulation of lipid homeostasis in fungi: Implications for anti-fungal drug development.

abstract：:Angiosperms display a huge variety of floral forms. The development of the ABC-model for floral organ identity, almost 20 years ago, has created an excellent basis for comparative floral development (evo-devo) studies. These have resulted in an increasingly more detailed understanding of the molecular control circuitr...

journal_title：Seminars in cell & developmental biology

authors： Rijpkema AS,Vandenbussche M,Koes R,Heijmans K,Gerats T

更新日期：2010-02-01 00:00:00

abstract：:Since the identification of a metazoan counterpart to yeast Mediator nearly 15 years ago, a convergent body of biochemical and molecular genetic studies have confirmed their structural and functional relationship as an integrative hub through which regulatory information conveyed by signal activated transcription fact...

journal_title：Seminars in cell & developmental biology

authors： Spaeth JM,Kim NH,Boyer TG

更新日期：2011-09-01 00:00:00

abstract：:Ascidians are urochordates, marine invertebrates with non-feeding motile chordate tadpole larvae, except in the family Molgulidae. Urodele, or tailed, Molgulids have typical ascidian chordate tadpole larvae possessing tails with muscle cells, a notochord, and a dorsal hollow nerve cord. In contrast, anural (or tail-le...

journal_title：Seminars in cell & developmental biology

authors： Huber JL,da Silva KB,Bates WR,Swalla BJ

更新日期：2000-12-01 00:00:00

abstract：:Gap junctions and hemichannels comprised of connexins influence epidermal proliferation and differentiation. Significant advances in our understanding of the functional role of connexins in the skin have been made by studying the diseases caused by connexin mutations. Eleven clinically defined cutaneous disorders with...

journal_title：Seminars in cell & developmental biology

authors： Lilly E,Sellitto C,Milstone LM,White TW

更新日期：2016-02-01 00:00:00

abstract：:Aluminium salts have been used as adjuvants in vaccines for almost a century, but still no clear understanding of the mechanisms behind the immune stimulating properties of aluminium based adjuvants is recognized. Aluminium adjuvants consist of aggregates and upon administration of a vaccine, the aggregates will be re...

journal_title：Seminars in cell & developmental biology

authors： Danielsson R,Eriksson H

更新日期：2021-01-07 00:00:00

abstract：:Discovering how organisms and their proteins adapt to extreme conditions is a complicated process. Every condition has its own set of adaptations that make it uniquely stable in its environment. The purpose of our review is to discuss what is known in the extremophilic community about protein adaptations. To simplify ...

journal_title：Seminars in cell & developmental biology

authors： Brininger C,Spradlin S,Cobani L,Evilia C

更新日期：2018-12-01 00:00:00

abstract：:The formation of ovules is a key step in the plant life cycle which alternates between a diploid and haploid generation, the sporophyte and the gametophyte. The transitions between the two generations in the female occur in the ovule, the site of meiosis, female gametogenesis and double fertilization. The intimate ass...

journal_title：Seminars in cell & developmental biology

authors： Grossniklaus U,Schneitz K

更新日期：1998-04-01 00:00:00

abstract：:The autophagy pathway known also as macroautophagy (herein referred to as autophagy) is characterized by the formation of double-membrane organelles that capture cytosolic material. Based on pathway termination alternatives, autophagy has been divided into degradative and secretory. During degradative autophagy, autop...

journal_title：Seminars in cell & developmental biology

authors： Claude-Taupin A,Bissa B,Jia J,Gu Y,Deretic V

更新日期：2018-11-01 00:00:00

abstract：:The design and analysis of experiments using gene expression microarrays is a topic of considerable current research, and work is beginning to appear on the analysis of proteomics and metabolomics data by mass spectrometry and NMR spectroscopy. The literature in this area is evolving rapidly, and commercial software f...

journal_title：Seminars in cell & developmental biology

authors： Rocke DM

更新日期：2004-12-01 00:00:00

abstract：:Demyelinating disorders of the central white matter are among the most prevalent and disabling conditions in neurology. Since myelin-producing oligodendrocytes comprise the principal cell type deficient or lost in these conditions, their replacement by new cells generated from transplanted bipotential oligodendrocyte-...

journal_title：Seminars in cell & developmental biology

authors： Goldman SA,Mariani JN,Madsen PM

更新日期：2021-01-04 00:00:00

abstract：:When studying the living endosome one must first recognise that we are not studying a single discrete organelle but rather a highly dynamic interconnected network of membrane-bound compartments. Endocytosed molecules are sorted and transported through various polymorphic intracellular organelles that mature and intera...

journal_title：Seminars in cell & developmental biology

authors： Kerr M,Teasdale RD

更新日期：2014-07-01 00:00:00

abstract：:The Nonsense-mediated mRNA Decay (NMD) pathway is an RNA quality control pathway conserved among eukaryotic cells. While historically thought to predominantly recognize transcripts with premature termination codons, it is now known that the NMD pathway plays a variety of roles, from homeostatic events to control of vi...

journal_title：Seminars in cell & developmental biology

authors： Leon K,Ott M

更新日期：2020-06-15 00:00:00

abstract：:The endoplasmic reticulum (ER) is an intracellular compartment devoted to the synthesis, segregation and folding of soluble and membrane secretory proteins. Some mutations in these proteins lead to their incorrect or incomplete folding in the ER. The ER has a quality control system which detects misfolded proteins and...

journal_title：Seminars in cell & developmental biology

authors： Chevet E,Jakob CA,Thomas DY,Bergeron JJ

更新日期：1999-10-01 00:00:00

abstract：:Polycomb group (PcG) proteins play essential roles in animal and plant life cycles by controlling the expression of important developmental regulators. These structurally heterogeneous proteins form multimeric protein complexes that control higher order chromatin structure and, thereby, the expression state of their t...

journal_title：Seminars in cell & developmental biology

authors： Reyes JC,Grossniklaus U

更新日期：2003-02-01 00:00:00

abstract：:Gene duplication events produce both perfect and imperfect copies of genes. Perfect copies are said to be functionally redundant when knockout of one gene produces no 'scoreable', phenotypic effects. Preserving identical, duplicate copies of genes is problematic as all copies are prone to accumulate neutral mutations ...

journal_title：Seminars in cell & developmental biology

authors： Krakauer DC,Nowak MA

更新日期：1999-10-01 00:00:00

abstract：:Lipids are now widely considered to play a variety of important roles in T-cell mediated immunity, including serving as antigens. Lipid-based antigens are presented by a specialised group of glycoproteins termed CD1. In humans, three classes of CD1 molecules exist: group 1 (CD1a, CD1b, CD1c), group 2 (CD1d), and group...

journal_title：Seminars in cell & developmental biology

authors： Le Nours J,Shahine A,Gras S

更新日期：2018-12-01 00:00:00

abstract：:Multiple myeloma is a bone marrow neoplasia with an incidence of 6/100,000/year in Europe. While the disease remains incurable, the development of novel treatments such as autologous stem cell transplantation, proteasome inhibitors and monoclonal antibodies has led to an increasing subset of patients living with long-...

journal_title：Seminars in cell & developmental biology

authors： Diaz-delCastillo M,Chantry AD,Lawson MA,Heegaard AM

更新日期：2020-11-03 00:00:00

abstract：:The hallmarks of cancer include multiple alterations in the physiological processes occurring in normal tissues, such as cell proliferation, apoptosis, and restricted cell migration. These aberrant behaviors are due to genetic and epigenetic changes that affect signaling pathways controlling cancer cells, as well as t...

journal_title：Seminars in cell & developmental biology

authors： Rehman M,Tamagnone L

更新日期：2013-03-01 00:00:00

abstract：:The ancestors of modern Metazoa were constructed in large part by the foldings and distortions of two-dimensional sheets of epithelial cells. This changed approximately 600 million years ago with the evolution of mesenchymal cells. These cells arise as the result of epithelial cell delamination through a reprogramming...

journal_title：Seminars in cell & developmental biology

authors： Baum B,Settleman J,Quinlan MP

更新日期：2008-06-01 00:00:00

abstract：:Intrinsically disordered proteins as computationally predicted account for ∼1/3 of eukaryotic proteomes, are involved in a plethora of biological functions, and have been linked to several human diseases as a result of their dysfunctions. Here, we present a picture wherein an energetic continuum describes protein stru...

journal_title：Seminars in cell & developmental biology

authors： Moosa MM,Ferreon JC,Ferreon ACM

更新日期：2020-03-01 00:00:00

abstract：:During nervous system development stem cell daughters must exit the proliferative cycle to adopt specific neural and glial fates and they must do so in the correct positions. Cell proliferation in the central nervous system occurs in neuroepithelia such as the neural retina and the ventricular zones. As cells are assi...

journal_title：Seminars in cell & developmental biology

authors： Jones C,Moses K

更新日期：2004-02-01 00:00:00

abstract：:For over a decade, studies of messenger RNA regulation have revealed an unprecedented level of connectivity between the RNA pool and global gene expression. These connections are underpinned by a vast array of RNA elements that coordinate RNA-protein and RNA-RNA interactions, each directing mRNA fate from transcriptio...

journal_title：Seminars in cell & developmental biology

authors： Rodriguez W,Macveigh-Fierro D,Miles J,Muller M

更新日期：2020-06-07 00:00:00

abstract：:Blood vessels are essential conduits of nutrients and oxygen throughout the body. The formation of these vessels involves angiogenic sprouting, a complex process entailing highly integrated cell behaviors and signaling pathways. In this review, we discuss how endothelial cells initiate a vessel sprout through interact...

journal_title：Seminars in cell & developmental biology

authors： Chappell JC,Wiley DM,Bautch VL

更新日期：2011-12-01 00:00:00

abstract：:Until the discovery of human embryonic stem cells and human induced pluripotent stem cells, biotechnology companies were severely limited in the number of human tissues that they could model in large-scale in vitro studies. Until this point, companies have been limited to immortalized cancer lines or a small number of...

journal_title：Seminars in cell & developmental biology

authors： Salick MR,Lubeck E,Riesselman A,Kaykas A

更新日期：2020-07-09 00:00:00

abstract：:Understanding how some animals are immortal and avoid the ageing process is important. We currently know very little about how they achieve this. Research with genetic model systems has revealed the existence of conserved genetic pathways and molecular processes that affect longevity. Most of these established model o...

journal_title：Seminars in cell & developmental biology

authors： Sahu S,Dattani A,Aboobaker AA

更新日期：2017-10-01 00:00:00

abstract：:Mesoderm and endoderm formation in Xenopus involves the coordinated efforts of maternally and zygotically expressed transcription factors together with growth factor signalling, including members of the TGFbeta and wnt families. In this review we discuss our current state of knowledge of these pathways, and describe i...

journal_title：Seminars in cell & developmental biology

authors： Wardle FC,Smith JC

更新日期：2006-02-01 00:00:00

abstract：:During development, diffusible ligands, known as morphogens, are thought to move across fields of cells, regulating gene expression in a concentration dependent manner. The case for morphogens has been convincingly made for the Decapentapleigic (Dpp), Wingless (Wg) and Hedgehog (Hh) proteins in the Drosophila wing. In...

journal_title：Seminars in cell & developmental biology

authors： Cadigan KM

更新日期：2002-04-01 00:00:00

abstract：:With the arrival of atomic force microscopy (AFM) about thirty years ago, this new imaging tool opened up a new area for the exploration of biological samples, ranging from the tissue and cellular level down to the supramolecular scale. Commercial instruments of this new imaging technique began to appear in the five y...

journal_title：Seminars in cell & developmental biology

authors： Braet F,Taatjes DJ,Wisse E

更新日期：2018-01-01 00:00:00

abstract：:The nuclear pore complex (NPC) is the selective gateway through which all molecules must pass when entering or exiting the nucleus. It is a cog in the gene expression pathway, an entrance to the nucleus exploited by viruses, and a highly-tuned nanoscale filter. The NPC is a large proteinaceous assembly with a central ...

journal_title：Seminars in cell & developmental biology

authors： Stanley GJ,Fassati A,Hoogenboom BW

更新日期：2017-08-01 00:00:00

abstract：:With computation models playing an ever increasing role in the advancement of science, it is important that researchers understand what it means to model something; recognize the implications of the conceptual, mathematical and algorithmic steps of model construction; and comprehend what models can and cannot do. Here...

journal_title：Seminars in cell & developmental biology

authors： Brodland GW

更新日期：2015-12-01 00:00:00