Abstract:
:Until the discovery of human embryonic stem cells and human induced pluripotent stem cells, biotechnology companies were severely limited in the number of human tissues that they could model in large-scale in vitro studies. Until this point, companies have been limited to immortalized cancer lines or a small number of primary cell types that could be extracted and expanded. Nowadays, protocols continue to be developed in the stem cell field, enabling researchers to model an ever-growing library of cell types in controlled, large-scale screens. One differentiation method in particular- cerebral organoids- shows substantial potential in the field of neuroscience and developmental neurobiology. Cerebral organoid technology is still in an early phase of development, and there are several challenges that are currently being addressed by academic and industrial researchers alike. Here we briefly describe some of the early adopters of cerebral organoids, several of the challenges that they are likely facing, and various technologies that are currently being implemented to overcome them.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Salick MR,Lubeck E,Riesselman A,Kaykas Adoi
10.1016/j.semcdb.2020.05.024subject
Has Abstractpub_date
2020-07-09 00:00:00eissn
1084-9521issn
1096-3634pii
S1084-9521(19)30302-7pub_type
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journal_title:Seminars in cell & developmental biology
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