Abstract:
:The glyoxalase system has been studied since 1913. The biochemical function of this enzymatic system is the metabolism of reactive dicarbonyl metabolites, glyoxal and methylglyoxal, to less reactive products. In the last decade research has shown that methylglyoxal is the precursor of quantitatively important damage to the proteome and genome, forming mainly hydroimidazolone and imidazopurinone adducts in protein and DNA respectively. The aim of this article is to review the evidence of the involvement of the glyoxalase system in ageing and role of glyoxalase in future research into healthy ageing-mainly in mammalian systems for insights into consequences and interventions in human health. Protein and DNA damage by glyoxalase system substrates is linked to dysfunction of proteins susceptible to dicarbonyl modification-the dicarbonyl proteome, and DNA instability and mutation. A component of the glyoxalase system, glyoxalase 1, is a gene with expression influential on lifespan-increasing longevity being associated with increased expression of glyoxalase 1. The glyoxalase 1 gene is also a site of copy number variation in both transcribed and non-transcribed regions giving rise to population variation of expression. The glyoxalase system and Glo1 expression particularly is therefore likely linked to healthy ageing.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Xue M,Rabbani N,Thornalley PJdoi
10.1016/j.semcdb.2011.02.013subject
Has Abstractpub_date
2011-05-01 00:00:00pages
293-301issue
3eissn
1084-9521issn
1096-3634pii
S1084-9521(11)00026-7journal_volume
22pub_type
杂志文章,评审abstract::From the mid-19th century until the 1980's, frogs and toads provided important research models for many fundamental questions in visual neuroscience. In the present century, they have been largely neglected. Yet they are animals with highly developed vision, a complex retina built on the basic vertebrate plan, an acce...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2020.05.011
更新日期:2020-10-01 00:00:00
abstract::Outlines of the genetic circuitry regulating male gametogenesis in Drosophila have begun to appear. Cessation of mitotic proliferation and onset of the meiotic program is regulated by the bam and bgcn genes acting within male germ cells and a TGF-beta class signaling cascade in surrounding somatic cells. Onset of sper...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.1998.0227
更新日期:1998-08-01 00:00:00
abstract::The endoplasmic reticulum (ER) is an intracellular compartment devoted to the synthesis, segregation and folding of soluble and membrane secretory proteins. Some mutations in these proteins lead to their incorrect or incomplete folding in the ER. The ER has a quality control system which detects misfolded proteins and...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.1999.0316
更新日期:1999-10-01 00:00:00
abstract::The notion of feedback is fundamental for understanding signal transduction networks. Feedback loops attenuate or amplify signals, change the network dynamics and modify the input-output relationships between the signal and the target. Negative feedback provides robustness to noise and adaptation to perturbations, but...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.09.024
更新日期:2016-02-01 00:00:00
abstract::The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.semcdb.2013.05.010. The duplicate article has therefore been withdrawn. ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章
doi:10.1016/j.semcdb.2013.05.011
更新日期:2013-05-18 00:00:00
abstract::The paralogous transcription factors ChREBP and MondoA, together with their common binding partner Mlx, have emerged as key mediators of intracellular glucose sensing. By regulating target genes involved in glycolysis and lipogenesis, they mediate metabolic adaptation to changing glucose levels. As disturbed glucose h...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2012.02.007
更新日期:2012-08-01 00:00:00
abstract::By the development of information theory in 1948 by Claude Shannon to address the problems in the field of data storage and data communication over (noisy) communication channel, it has been successfully applied in many other research areas such as bioinformatics and systems biology. In this manuscript, we attempt to ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.12.006
更新日期:2016-03-01 00:00:00
abstract::Polycomb group (PcG) proteins play essential roles in animal and plant life cycles by controlling the expression of important developmental regulators. These structurally heterogeneous proteins form multimeric protein complexes that control higher order chromatin structure and, thereby, the expression state of their t...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/s1084-9521(02)00139-8
更新日期:2003-02-01 00:00:00
abstract::Recent appraisals of mesenteric anatomy clarify its structure and show a continuous and helical-shaped organ. This new model signifies a departure from the conventional model which described multiple, separate "mesenteries". Renaissance anatomists depicted the mesentery as a continuous structure. Events that led to re...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2018.10.003
更新日期:2019-08-01 00:00:00
abstract::Yeast prions are atypical genetic elements that are transmitted as heritable protein conformations. [PSI+], [URE3], and [PIN+] are three well-studied prions in the budding yeast, Saccharomyces cerevisiae. In the last three years, several additional prions have been reported in yeast, including [SWI+], [OCT+], [MCA], [...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2011.03.003
更新日期:2011-07-01 00:00:00
abstract::Mammalian genomes are pervasively transcribed, with long noncoding RNAs being the most abundant fraction. Recent studies have highlighted the central role played by these transcripts in several physiological and pathological processes. Despite several metabolic features shared between coding and noncoding transcripts,...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2017.11.012
更新日期:2018-07-01 00:00:00
abstract::Autophagy, a conserved self-eating process for the bulk degradation of cytoplasmic materials, involves double-membrane autophagosomes formed when an isolation membrane emerges and their direct fusion with lysosomes for degradation. For the early biogenesis of autophagosomes and their later degradation in lysosomes, me...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2016.07.009
更新日期:2016-12-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a prevalent inflammatory joint disease with enigmatic flares, which causes swelling, pain, and irreversible connective tissue damage. Recently, it has been demonstrated in murine models of RA that the popliteal lymph node (PLN) is a biomarker of arthritic flare, as it "expands" in size and...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.01.001
更新日期:2015-02-01 00:00:00
abstract::Polycystic kidney disease (PKD), comprising autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD), is characterized by incessant cyst formation in the kidney and liver. ADPKD and ARPKD represent the leading genetic causes of renal disease in adults and children,...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2020.05.003
更新日期:2020-05-28 00:00:00
abstract::The exchange of substances between metazoan and the environment takes place across transporting epithelia that have two fundamental differentiated features: tight junctions (TJ) and apical/basolateral polarity. Usually, reviews of the structure and function of transporting epithelia follow a historical description of ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2014.09.010
更新日期:2014-12-01 00:00:00
abstract::No abstractCopyright 1997 Academic Press Limited Copyright 1997Academic Press Limited ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章
doi:10.1006/scdb.1997.0170
更新日期:1997-10-01 00:00:00
abstract::Epithelial cell organization relies on a set of proteins that interact in an intricate way and which are called polarity complexes. These complexes are involved in the determination of the apico-basal axis and in the positioning and stability of the cell-cell junctions called adherens junctions at the apico-lateral bo...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2017.10.018
更新日期:2018-09-01 00:00:00
abstract::Canalization, or phenotypic robustness in the face of environmental and genetic perturbation, is an emergent property of living systems. Although this phenomenon has long been recognized, its molecular underpinnings have remained enigmatic until recently. Here, we review the contributions of the molecular chaperone Hs...
journal_title:Seminars in cell & developmental biology
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.semcdb.2018.05.015
更新日期:2019-04-01 00:00:00
abstract::The vertebrate brain is organized, from its embryonic origin and throughout adult life, around a dynamic and complex fluid, the cerebrospinal fluid (CSF). There is growing interest in the composition, dynamics and function of the CSF in brain development research. It has been demonstrated in higher vertebrates that CS...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2019.09.006
更新日期:2020-06-01 00:00:00
abstract::Mitochondria are the key energy-producing organelles and cellular source of reactive species. They are responsible for managing cell life and death by a balanced homeostasis passing through a network of structures, regulated principally via fission and fusion. Herein we discuss about the most advanced findings conside...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2019.05.022
更新日期:2020-02-01 00:00:00
abstract::Embryonic mammary gland development involves the formation of mammary placodes, invagination of flask-shaped mammary buds and development of miniature bi-layered ductal trees. Currently there is a good understanding of the factors that contribute to ectodermal cell movements to create these appendages and of pathways ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2020.12.012
更新日期:2021-01-17 00:00:00
abstract::The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular basement membrane (BM) and the interstitial ECM is identified as a crucial component of the vasculature. We here focus on the unique molecular composition and scaffolding of the capillary ECM, which provides structural support to b...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2018.08.007
更新日期:2019-05-01 00:00:00
abstract::Growth factors acting through receptor tyrosine kinases (RTKs) of ERBB family, along with steroid hormones (SH) acting through nuclear receptors (NRs), are critical signalling mediators of cellular processes. Deregulations of ERBB and steroid hormone receptors are responsible for several diseases, including cancer, th...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.11.004
更新日期:2016-02-01 00:00:00
abstract::Given the large socio-economic burden of cancer, there is an urgent need for in vivo animal cancer models that can provide a rationale for personalised therapeutic regimens that are translatable to the clinic. Recent developments in establishing mouse models that closely resemble human lung cancers involve the applica...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2014.04.002
更新日期:2014-03-01 00:00:00
abstract::Intrinsically disordered proteins as computationally predicted account for ∼1/3 of eukaryotic proteomes, are involved in a plethora of biological functions, and have been linked to several human diseases as a result of their dysfunctions. Here, we present a picture wherein an energetic continuum describes protein stru...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2018.05.007
更新日期:2020-03-01 00:00:00
abstract::During vertebrate gastrulation, large cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish offer many genetic and experimental advantages for studying vertebrate gastrulation movements. For instance, several mutants, including silberblick, knypek and trilob...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/s1084952102001003
更新日期:2002-12-01 00:00:00
abstract::Clustered protocadherins mediate neuronal self-recognition and non-self discrimination-neuronal "barcoding"-which underpin neuronal self-avoidance in vertebrate neurons. Recent structural, biophysical, computational, and cell-based studies on protocadherin structure and function have led to a compelling molecular mode...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2017.07.023
更新日期:2017-09-01 00:00:00
abstract::Research using Xenopus laevis has made enormous contributions to our understanding of vertebrate development, control of the eukaryotic cell cycle and the cytoskeleton. One limitation, however, has been the lack of systematic genetic studies in Xenopus to complement molecular and cell biological investigations. Work w...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2005.11.009
更新日期:2006-02-01 00:00:00
abstract::The family Cichlidae contains approximately 2000 species that live in diverse freshwater habitats including murky lakes, turbid rivers, and clear lakes from both the Old and New Worlds. Their visual systems are similarly diverse and have evolved specific sensitivities that differ along several axes of variation. Varia...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2020.04.015
更新日期:2020-10-01 00:00:00
abstract::The sympathetic nervous system represents a critical mechanism for homoeostatic blood pressure regulation in humans. This review focuses on age-related alterations in neurocirculatory regulation in men and women by highlighting human studies that examined the relationship between muscle sympathetic nerve activity (MSN...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2021.01.001
更新日期:2021-01-16 00:00:00