Abstract：
:Growth factors acting through receptor tyrosine kinases (RTKs) of ERBB family, along with steroid hormones (SH) acting through nuclear receptors (NRs), are critical signalling mediators of cellular processes. Deregulations of ERBB and steroid hormone receptors are responsible for several diseases, including cancer, thus demonstrating the central role played by both systems. This review will summarize and shed light on an emerging crosstalk between these two important receptor families. How this mutual crosstalk is attained, such as through extensive genomic and non-genomic interactions, will be addressed. In light of recent studies, we will describe how steroid hormones are able to fine-tune ERBB feedback loops, thus impacting on cellular output and providing a new key for understanding the complexity of biological processes in physiological or pathological conditions. In our understanding, the interactions between steroid hormones and RTKs deserve further attention. A system biology approach and advanced technologies for the analysis of RTK-SH crosstalk could lead to major advancements in molecular medicine, providing the basis for new routes of pharmacological intervention in several diseases, including cancer.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
D'Uva G,Lauriola Mdoi
10.1016/j.semcdb.2015.11.004subject
Has Abstractpub_date
2016-02-01 00:00:00pages
143-52eissn
1084-9521issn
1096-3634pii
S1084-9521(15)00250-5journal_volume
50pub_type
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journal_title：Seminars in cell & developmental biology
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