The role of the cytoskeleton and molecular motors in endosomal dynamics.

Abstract:

:The endocytic pathway is essential for processes that define how cells interact with their environment, including receptor signalling, cell adhesion and migration, pathogen entry, membrane protein turnover and nutrient uptake. The spatial organisation of endocytic trafficking requires motor proteins that tether membranes or transport them along the actin and microtubule cytoskeletons. Microtubules, actin filaments and motor proteins also provide force to deform and assist in the scission of membranes, thereby facilitating endosomal sorting and the generation of transport intermediates.

journal_name

Semin Cell Dev Biol

authors

Granger E,McNee G,Allan V,Woodman P

doi

10.1016/j.semcdb.2014.04.011

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

20-9

eissn

1084-9521

issn

1096-3634

pii

S1084-9521(14)00082-2

journal_volume

31

pub_type

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