Novel functions for 'nuclear factors' in the cytoplasm: the Sex-lethal paradigm.

abstract：:During development, epithelial cells in some tissues acquire a polarity orthogonal to their apical-basal axis. This polarity, referred to as planar cell polarity (PCP), or tissue polarity, is essential for the normal physiological function of many epithelia. Early studies of PCP focused on insect epithelia (Lawrence, ...

journal_title：Seminars in cell & developmental biology

authors： Axelrod JD

更新日期：2009-10-01 00:00:00

abstract：:Vascular plants, unlike bryophytes, have a strong root-shoot dichotomy in which the tissue systems are mutually interdependent; roots are completely dependent on shoots for photosynthetic sugars, and shoots are completely dependent on roots for water and mineral nutrients. Long-distance communication between shoot and...

journal_title：Seminars in cell & developmental biology

authors： Wheeldon CD,Bennett T

更新日期：2020-06-20 00:00:00

abstract：:Can plants perceive sound? And what sounds are they likely to be "listening" to? The environment of plants includes many informative sounds, produced by biotic and abiotic sources. An ability to respond to these sounds could thus have a significant adaptive value for plants. We suggest the term phytoacoustics to descr...

journal_title：Seminars in cell & developmental biology

authors： Khait I,Obolski U,Yovel Y,Hadany L

更新日期：2019-08-01 00:00:00

abstract：:The Sox transcription factor family consists of 20 members in the human genome. Many of them are key determinants of cellular identities and possess the capacity to reprogram cell fates by pioneering the epigenetic remodeling of the genome. This activity is intimately tied to their ability to specifically bind and ben...

journal_title：Seminars in cell & developmental biology

authors： Hou L,Srivastava Y,Jauch R

更新日期：2017-03-01 00:00:00

abstract：:IgE-mediated food allergy is a developing global health problem with prevalence rising at alarmingly fast rates. In this review, we discuss the interplay between genetics, epigenetics, and environmental exposures in the pathogenesis of food allergies. We aim to highlight the most recent evidence that suggests how epig...

journal_title：Seminars in cell & developmental biology

authors： Quake C,Nadeau KC

更新日期：2015-07-01 00:00:00

abstract：:The Drosophila heart, also called the dorsal vessel, is a linear tube consisting of two major cell types, namely cardioblasts which serve as cardiomyocytes and pericardial cells which surround its outer surface. This organ is derived from segmental clusters of cells in the dorsal mesoderm during early embryonic develo...

journal_title：Seminars in cell & developmental biology

authors： Frasch M

更新日期：1999-02-01 00:00:00

abstract：:α-synuclein and Tau are proteins prone to pathological misfolding and aggregation that are normally found in the presynaptic and axonal compartments of neurons. Misfolding initiates a homo-oligomerization and aggregation cascade culminating in cerebral accumulation of aggregated α-synuclein and Tau in insoluble protei...

journal_title：Seminars in cell & developmental biology

authors： Yan X,Uronen RL,Huttunen HJ

更新日期：2020-03-01 00:00:00

abstract：:Viruses have evolved strategies to evade immunity mediated by antibody and complement. Herpesviruses and coronaviruses encode IgG Fc binding proteins that inhibit IgG activity, enabling the virus or infected cell to escape antibody attack. Herpesviruses, vaccinia virus and HIV-1 have the capacity to interfere with com...

journal_title：Seminars in cell & developmental biology

authors： Lubinski J,Nagashunmugam T,Friedman HM

更新日期：1998-06-01 00:00:00

abstract：:Although largely less numerous and characterized than bacterial secreted effectors, several viral virulence factors are secreted by virus infected cells. However, their mode of secretion only starts to be studied at the molecular level. Several of these viral effectors are secreted using an unconventional secretion pa...

journal_title：Seminars in cell & developmental biology

authors： Schatz M,Tong PBV,Beaumelle B

更新日期：2018-11-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is an intracellular compartment devoted to the synthesis, segregation and folding of soluble and membrane secretory proteins. Some mutations in these proteins lead to their incorrect or incomplete folding in the ER. The ER has a quality control system which detects misfolded proteins and...

journal_title：Seminars in cell & developmental biology

authors： Chevet E,Jakob CA,Thomas DY,Bergeron JJ

更新日期：1999-10-01 00:00:00

abstract：:The actin cytoskeleton is critically involved in a variety of cell functions. The Arp2/3 complex mediates branching of filamentous actin. The members of the Wiskott-Aldrich syndrome protein (WASP) family are major regulators of the complex. As such, the family proteins are also involved in numerous aspects of cell bio...

journal_title：Seminars in cell & developmental biology

authors： Oda A,Eto K

更新日期：2013-04-01 00:00:00

abstract：:Gene duplication events produce both perfect and imperfect copies of genes. Perfect copies are said to be functionally redundant when knockout of one gene produces no 'scoreable', phenotypic effects. Preserving identical, duplicate copies of genes is problematic as all copies are prone to accumulate neutral mutations ...

journal_title：Seminars in cell & developmental biology

authors： Krakauer DC,Nowak MA

更新日期：1999-10-01 00:00:00

abstract：:How limited is the ability of stem cells to generate gametes or differentiated somatic cells? Recent outcomes of research with stem cells from both embryonic and adult origin will be discussed with particular attention to results that challenge conventional wisdom about the presence of reproductive stem cells in adult...

journal_title：Seminars in cell & developmental biology

authors： McLean DJ

更新日期：2006-08-01 00:00:00

abstract：:During the development of vertebrate nervous system, distinct classes of motor neurons and interneurons are generated at distinct dorsoventral positions in the ventral neural tube. The differentiation of these neuronal subtypes is directed by the secreted protein Sonic Hedgehog (Shh). Shh acts in a graded manner to es...

journal_title：Seminars in cell & developmental biology

authors： Briscoe J,Ericson J

更新日期：1999-06-01 00:00:00

abstract：:Complex interactions occur among embryonic, placental and maternal tissues during embryo implantation. Many of these interactions are controlled by growth factors, extracellular matrix and cell surface components that share the ability to bind heparan sulfate (HS) polysaccharides. HS is carried by several classes of c...

journal_title：Seminars in cell & developmental biology

authors： Kirn-Safran CB,D'Souza SS,Carson DD

更新日期：2008-04-01 00:00:00

abstract：:Blood vessels are essential conduits of nutrients and oxygen throughout the body. The formation of these vessels involves angiogenic sprouting, a complex process entailing highly integrated cell behaviors and signaling pathways. In this review, we discuss how endothelial cells initiate a vessel sprout through interact...

journal_title：Seminars in cell & developmental biology

authors： Chappell JC,Wiley DM,Bautch VL

更新日期：2011-12-01 00:00:00

abstract：:Intrinsically disordered proteins as computationally predicted account for ∼1/3 of eukaryotic proteomes, are involved in a plethora of biological functions, and have been linked to several human diseases as a result of their dysfunctions. Here, we present a picture wherein an energetic continuum describes protein stru...

journal_title：Seminars in cell & developmental biology

authors： Moosa MM,Ferreon JC,Ferreon ACM

更新日期：2020-03-01 00:00:00

abstract：:The small ubiquitin-like modifier (SUMO) is covalently attached to lysine residues in target proteins and in doing so changes the properties of the modified protein. Here we examine the role of SUMO modification in transcriptional regulation. SUMO addition to components of the transcriptional apparatus does not have a...

journal_title：Seminars in cell & developmental biology

authors： Girdwood DW,Tatham MH,Hay RT

更新日期：2004-04-01 00:00:00

abstract：:Spatial patterns of neuronal connectivity are critical for neural circuit function and information processing. For many neuron types, the development of stereotyped dendritic and axonal territories involves reiterative contacts between neurites and successive re-calibration of branch outgrowth and directionality. Here...

journal_title：Seminars in cell & developmental biology

authors： Lefebvre JL

更新日期：2017-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as an essential regulatory component in plants. Many of the known miRNAs are evolutionarily conserved across diverse plant species and function in the regulatory control of fundamentally important biological processes such as developmental timing, patterning, and response to environment...

journal_title：Seminars in cell & developmental biology

authors： Xie Z,Khanna K,Ruan S

更新日期：2010-10-01 00:00:00

abstract：:The glyoxalase system consists of glyoxalase I and glyoxalase II. Glyoxalase I catalyzes the conversion of methylglyoxal (CH(3)COCHO), a metabolite derived from glycolysis, with glutathione to S-D-lactoylglutathione, while glyoxalase II hydrolyses this glutathione thiolester to D-lactic acid and glutathione. Since met...

journal_title：Seminars in cell & developmental biology

authors： Inoue Y,Maeta K,Nomura W

更新日期：2011-05-01 00:00:00

abstract：:There has been widespread speculation regarding the possibility of reprogramming human somatic nuclei by transfer into oocytes. Stem cells derived from such reconstructed embryos could theoretically provide a source of autologous tissue for therapeutic transplantation. However the biological, technical and ethical hur...

journal_title：Seminars in cell & developmental biology

authors： Kind A,Colman A

更新日期：1999-06-01 00:00:00

abstract：:During development cranial neural crest cells (NCCs) display a striking transition from collective to single-cell migration, but the mechanisms enabling individual NCCs to separate from the neural crest tissue are still incompletely understood. In this study we have employed atomic force microscopy (AFM) to investigat...

journal_title：Seminars in cell & developmental biology

authors： Blaue C,Kashef J,Franz CM

更新日期：2018-01-01 00:00:00

abstract：:In the crowded intranuclear environment, entropic depletion forces between macromolecules are expected to be strong. A review of simulations of linear polymers leads to several predictions about probable conformations of a polynucleosome chain in these conditions. These include a globular conformation, variable compac...

journal_title：Seminars in cell & developmental biology

authors： Hancock R

更新日期：2007-10-01 00:00:00

abstract：:Cholesterol is highly enriched in the brain compared to other tissues. Essentially all cholesterol in the brain is synthesized endogenously since plasma lipoproteins are unable to cross the blood-brain barrier. Cholesterol is transported within the central nervous system in the form of apolipoprotein E-containing lipo...

journal_title：Seminars in cell & developmental biology

authors： Vance JE,Hayashi H,Karten B

更新日期：2005-04-01 00:00:00

abstract：:The sculpting of embryonic tissues and organs into their functional morphologies involves the spatial and temporal regulation of mechanics at cell and tissue scales. Decades of in vitro work, complemented by some in vivo studies, have shown the relevance of mechanical cues in the control of cell behaviors that are cen...

journal_title：Seminars in cell & developmental biology

authors： Campàs O

更新日期：2016-07-01 00:00:00

abstract：:Differences between sexes of the same species in lifespan and aging rate are widespread. While the proximal and evolutionary causes of aging are well researched, the factors that contribute to sex differences in these traits have been less studied. The striking diversity of nematodes provides ample opportunity to stud...

journal_title：Seminars in cell & developmental biology

authors： Ancell H,Pires-daSilva A

更新日期：2017-10-01 00:00:00

abstract：:Newly synthesized polypeptide chains must fold and assemble into unique three-dimensional structures in order to become functionally active. In many cases productive folding depends on assistance from molecular chaperones, which act in preventing off-pathway reactions during folding that lead to aggregation. The inher...

journal_title：Seminars in cell & developmental biology

authors： Agashe VR,Hartl FU

更新日期：2000-02-01 00:00:00

abstract：:Phosphatidylinositols are important in intracellular signaling. In response to extracellular signals, these molecules undergo rapid turnover and generate second messengers including diacylglycerol, inositol 1,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate (PtdIns 3,4P2) and phosphatidylinositol 3,4,5-trispho...

journal_title：Seminars in cell & developmental biology

authors： Zhang X,Majerus PW

更新日期：1998-04-01 00:00:00

abstract：:Analysis of membrane transport in the yeast Saccharomyces cerevisiae continues to provide important insights into the molecular mechanisms that direct endocytic and lysosomal sorting pathways in eukaryotic cells. Recent findings include the identification of two novel endomembrane transport pathways, a Golgi-to-vacuol...

journal_title：Seminars in cell & developmental biology

authors： Burd CG,Babst M,Emr SD

更新日期：1998-10-01 00:00:00